STRA6 [The Human Chemical-Genetic Interaction Map Project]

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======= STRA6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: STRA6
  * **<color #00a2e8>Official Name</color>**: signaling receptor and transporter of retinol STRA6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=64220|64220]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BX79|Q9BX79]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=STRA6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20STRA6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610745|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a membrane protein involved in the metabolism of retinol. The encoded protein acts as a receptor for retinol/retinol binding protein complexes. This protein removes the retinol from the complex and transports it across the cell membrane. Defects in this gene are a cause of syndromic microphthalmia type 9 (MCOPS9). Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|vitamin A import|
|vitamin A transport|
|alveolar primary septum development|
|retinol transport|
|terpenoid transport|
|retinol transmembrane transporter activity|
|isoprenoid transport|
|nose morphogenesis|
|paramesonephric duct development|
|ductus arteriosus closure|
|uterus morphogenesis|
|pulmonary artery morphogenesis|
|lung vasculature development|
|vocal learning|
|imitative learning|
|lung saccule development|
|observational learning|
|diaphragm development|
|learned vocalization behavior or vocal learning|
|retinal binding|
|embryonic camera-type eye formation|
|eyelid development in camera-type eye|
|retinol binding|
|auditory behavior|
|nose development|
|mechanosensory behavior|
|vitamin transmembrane transport|
|pulmonary valve morphogenesis|
|smooth muscle tissue development|
|female genitalia development|
|pulmonary valve development|
|uterus development|
|adrenal gland development|
|embryonic camera-type eye morphogenesis|
|response to auditory stimulus|
|positive regulation of behavior|
|lung epithelium development|
|face morphogenesis|
|embryonic digestive tract development|
|embryonic eye morphogenesis|
|embryonic camera-type eye development|
|semi-lunar valve development|
|head morphogenesis|
|vitamin transport|
|lung alveolus development|
|body morphogenesis|
|genitalia development|
|digestive tract morphogenesis|
|face development|
|heart valve morphogenesis|
|artery morphogenesis|
|heart valve development|
|drug transmembrane transport|
|regulation of behavior|
|ventricular septum development|
|feeding behavior|
|artery development|
|retinoid metabolic process|
|female sex differentiation|
|neuromuscular process|
|diterpenoid metabolic process|
|cardiac septum development|
|camera-type eye morphogenesis|
|terpenoid metabolic process|
|endocrine system development|
|organic acid transmembrane transport|
|cardiac ventricle development|
|carboxylic acid transmembrane transport|
|digestive tract development|
|skeletal muscle organ development|
|monocarboxylic acid transport|
|organic hydroxy compound transport|
|isoprenoid metabolic process|
|digestive system development|
|learning|
|eye morphogenesis|
|drug transport|
|lung development|
|cardiac chamber development|
|respiratory tube development|
|respiratory system development|
|signaling receptor activity|
|response to mechanical stimulus|
|ear development|
|sensory organ morphogenesis|
|learning or memory|
|sex differentiation|
|kidney development|
|anion transmembrane transport|
|renal system development|
|embryonic organ morphogenesis|
|carboxylic acid transport|
|organic acid transport|
|muscle organ development|
|muscle tissue development|
|lipid transport|
|cognition|
|camera-type eye development|
|urogenital system development|
|lipid localization|
|eye development|
|visual system development|
|sensory system development|
|developmental growth|
|growth|
|blood vessel morphogenesis|
|gland development|
|reproductive structure development|
|reproductive system development|
|embryonic organ development|
|organic anion transport|
|muscle structure development|
|blood vessel development|
|vasculature development|
|cardiovascular system development|
|heart development|
|sensory organ development|
|embryonic morphogenesis|
|behavior|
|anion transport|
|protein-containing complex|
|tube morphogenesis|
|developmental process involved in reproduction|
|head development|
|tube development|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|ion transmembrane transport|
|animal organ morphogenesis|
|cellular lipid metabolic process|
|embryo development|
|response to drug|
|epithelium development|
|response to abiotic stimulus|
|lipid metabolic process|
|transmembrane transport|
|ion transport|
|nervous system process|
|integral component of plasma membrane|
|reproductive process|
|reproduction|
|tissue development|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|-2.17|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|-1.87|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7363
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.56 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='STRA6 Expression in NALM6 Cells: 1.56'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>