STRAP [The Human Chemical-Genetic Interaction Map Project]

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======= STRAP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: STRAP
  * **<color #00a2e8>Official Name</color>**: serine/threonine kinase receptor associated protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=11171|11171]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y3F4|Q9Y3F4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=STRAP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20STRAP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605986|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. STRAP plays a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein. {ECO:0000269|PubMed:16251192, ECO:0000269|PubMed:18984161}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WD40|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|SMN complex|
|negative regulation of pathway-restricted SMAD protein phosphorylation|
|SMN-Sm protein complex|
|maintenance of gastrointestinal epithelium|
|negative regulation of epithelial to mesenchymal transition|
|epithelial structure maintenance|
|spliceosomal snRNP assembly|
|regulation of pathway-restricted SMAD protein phosphorylation|
|negative regulation of epithelial cell migration|
|digestive system process|
|negative regulation of transforming growth factor beta receptor signaling pathway|
|negative regulation of cellular response to transforming growth factor beta stimulus|
|regulation of epithelial to mesenchymal transition|
|digestion|
|regulation of transforming growth factor beta receptor signaling pathway|
|regulation of cellular response to transforming growth factor beta stimulus|
|negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|negative regulation of epithelial cell proliferation|
|negative regulation of cellular response to growth factor stimulus|
|tissue homeostasis|
|regulation of epithelial cell migration|
|ribonucleoprotein complex assembly|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|ribonucleoprotein complex subunit organization|
|negative regulation of cell migration|
|regulation of cellular response to growth factor stimulus|
|negative regulation of cell motility|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions|
|negative regulation of cellular component movement|
|negative regulation of locomotion|
|multicellular organismal homeostasis|
|regulation of epithelial cell proliferation|
|signaling receptor binding|
|anatomical structure homeostasis|
|RNA splicing|
|negative regulation of protein phosphorylation|
|negative regulation of phosphorylation|
|ribonucleoprotein complex biogenesis|
|mRNA processing|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of protein modification process|
|negative regulation of cell population proliferation|
|mRNA metabolic process|
|negative regulation of cell differentiation|
|cellular protein-containing complex assembly|
|regulation of cell migration|
|negative regulation of transcription by RNA polymerase II|
|RNA processing|
|regulation of cell motility|
|negative regulation of developmental process|
|regulation of locomotion|
|regulation of cellular component movement|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|protein-containing complex assembly|
|regulation of phosphorylation|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|homeostatic process|
|RNA metabolic process|
|negative regulation of gene expression|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|system process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|-2.72|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-1.89|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-1.73|
|[[:results:exp534|Trientine 500μM R08 exp534]]|1.71|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|1.72|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|1.74|
|[[:results:exp496|Lead acetate 990μM R08 exp496]]|1.79|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|1.83|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|1.85|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|1.91|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.01|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|2.08|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|2.21|
|[[:results:exp183|IU1-C 25μM R04 exp183]]|2.37|
|[[:results:exp210|LB-100 2μM R05 exp210]]|2.37|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|2.51|
|[[:results:exp536|Vitamin-D3 40μM R08 exp536]]|2.57|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|2.77|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|3.06|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|3.07|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|3.35|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:csde1|CSDE1]]|0.491|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 311/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|11/28|
|blood|15/28|
|bone|11/26|
|breast|12/33|
|central nervous system|27/56|
|cervix|1/4|
|colorectal|5/17|
|esophagus|3/13|
|fibroblast|0/1|
|gastric|6/16|
|kidney|9/21|
|liver|4/20|
|lung|32/75|
|lymphocyte|11/16|
|ovary|2/26|
|pancreas|10/24|
|peripheral nervous system|4/16|
|plasma cell|14/15|
|prostate|0/1|
|skin|15/24|
|soft tissue|1/9|
|thyroid|1/2|
|upper aerodigestive|9/22|
|urinary tract|12/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2456
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.76 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='STRAP Expression in NALM6 Cells: 6.76'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>