STRN [The Human Chemical-Genetic Interaction Map Project]

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======= STRN =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: STRN
  * **<color #00a2e8>Official Name</color>**: striatin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6801|6801]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43815|O43815]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=STRN&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20STRN|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614765|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Calmodulin-binding protein which may function as scaffolding or signaling protein and may play a role in dendritic Ca(2+) signaling.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WD40|
|Striatin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|FAR/SIN/STRIPAK complex|
|armadillo repeat domain binding|
|protein phosphatase 2A binding|
|bicellular tight junction assembly|
|tight junction assembly|
|tight junction organization|
|estrogen receptor binding|
|apical junction assembly|
|dendrite development|
|cell-cell junction assembly|
|bicellular tight junction|
|cell-cell junction organization|
|dendritic spine|
|cell junction assembly|
|locomotory behavior|
|postsynaptic membrane|
|calmodulin binding|
|cell junction organization|
|postsynaptic density|
|protein-containing complex binding|
|Wnt signaling pathway|
|cell-cell signaling by wnt|
|neuronal cell body|
|dendrite|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|behavior|
|neuron projection development|
|negative regulation of cell population proliferation|
|neuron development|
|neuron differentiation|
|cell-cell signaling|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|generation of neurons|
|regulation of cell population proliferation|
|neurogenesis|
|cell development|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp20|Etoposide 10μM R00 exp20]]|-1.77|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|-1.75|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|1.83|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|2|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:atp6v1a|ATP6V1A]]|0.474|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.469|
|[[:human genes:t:tceb3c|TCEB3C]]|0.462|
|[[:human genes:r:rrm1|RRM1]]|0.462|
|[[:human genes:p:prim1|PRIM1]]|0.461|
|[[:human genes:k:krt78|KRT78]]|0.452|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.444|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.44|
|[[:human genes:o:orc1|ORC1]]|0.431|
|[[:human genes:a:atp6v1b2|ATP6V1B2]]|0.429|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.428|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.428|
|[[:human genes:t:ticrr|TICRR]]|0.427|
|[[:human genes:v:vps52|VPS52]]|0.427|
|[[:human genes:n:narfl|NARFL]]|0.42|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.419|
|[[:human genes:c:copa|COPA]]|0.418|
|[[:human genes:p:polr2j3|POLR2J3]]|0.417|
|[[:human genes:o:orc6|ORC6]]|0.415|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.414|
|[[:human genes:c:cdc6|CDC6]]|0.409|
|[[:human genes:r:rpl35|RPL35]]|0.408|
|[[:human genes:n:nol12|NOL12]]|0.408|
|[[:human genes:p:psmd3|PSMD3]]|0.408|
|[[:human genes:a:arhgef35|ARHGEF35]]|0.406|
|[[:human genes:p:psmc5|PSMC5]]|0.406|
|[[:human genes:s:slc4a1|SLC4A1]]|0.405|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.401|
|[[:human genes:s:sart1|SART1]]|0.401|
|[[:human genes:s:sf3a2|SF3A2]]|0.401|
|[[:human genes:p:polr2a|POLR2A]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2802
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.74 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='STRN Expression in NALM6 Cells: 5.74'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>