STX18 [The Human Chemical-Genetic Interaction Map Project]

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======= STX18 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: STX18
  * **<color #00a2e8>Official Name</color>**: syntaxin 18
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=53407|53407]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9P2W9|Q9P2W9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=STX18&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20STX18|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606046|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Syntaxin that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER. {ECO:0000269|PubMed:15029241}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Syntaxin-18 N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of ER to Golgi vesicle-mediated transport|
|endoplasmic reticulum membrane organization|
|regulation of ER to Golgi vesicle-mediated transport|
|regulation of Golgi organization|
|SNAP receptor activity|
|SNARE complex|
|endoplasmic reticulum organization|
|positive regulation of organelle assembly|
|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|
|membrane fusion|
|positive regulation of intracellular transport|
|regulation of organelle assembly|
|protein domain specific binding|
|regulation of intracellular transport|
|Golgi vesicle transport|
|endomembrane system organization|
|positive regulation of cellular component biogenesis|
|regulation of vesicle-mediated transport|
|Golgi membrane|
|positive regulation of organelle organization|
|membrane organization|
|regulation of cellular localization|
|endoplasmic reticulum membrane|
|regulation of cellular component biogenesis|
|positive regulation of transport|
|intracellular protein transport|
|endoplasmic reticulum|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|-1.82|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-1.8|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|1.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.493|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 145/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|5/28|
|blood|1/28|
|bone|1/26|
|breast|17/33|
|central nervous system|14/56|
|cervix|1/4|
|colorectal|2/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|2/16|
|kidney|10/21|
|liver|0/20|
|lung|10/75|
|lymphocyte|3/16|
|ovary|5/26|
|pancreas|3/24|
|peripheral nervous system|5/16|
|plasma cell|3/15|
|prostate|1/1|
|skin|5/24|
|soft tissue|2/9|
|thyroid|0/2|
|upper aerodigestive|2/22|
|urinary tract|8/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2379
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.78 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='STX18 Expression in NALM6 Cells: 4.78'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>