STXBP1 [The Human Chemical-Genetic Interaction Map Project]

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======= STXBP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: STXBP1
  * **<color #00a2e8>Official Name</color>**: syntaxin binding protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6812|6812]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P61764|P61764]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=STXBP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20STXBP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602926|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a syntaxin-binding protein. The encoded protein appears to play a role in release of neurotransmitters via regulation of syntaxin, a transmembrane attachment protein receptor. Mutations in this gene have been associated with infantile epileptic encephalopathy-4. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Sec1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of vesicle docking|
|regulation of vesicle docking|
|regulation of acrosomal vesicle exocytosis|
|positive regulation of glutamate secretion, neurotransmission|
|axon target recognition|
|regulation of glutamate secretion, neurotransmission|
|presynaptic dense core vesicle exocytosis|
|neuronal dense core vesicle exocytosis|
|negative regulation of synaptic transmission, GABAergic|
|dense core granule exocytosis|
|regulation of synaptic vesicle priming|
|regulation of synaptic vesicle fusion to presynaptic active zone membrane|
|SNARE complex assembly|
|positive regulation of glutamate secretion|
|presynaptic active zone membrane|
|regulation of SNARE complex assembly|
|synaptic vesicle maturation|
|platelet alpha granule|
|positive regulation of mast cell activation involved in immune response|
|synaptic vesicle priming|
|positive regulation of mast cell degranulation|
|regulation of glutamate secretion|
|phospholipase binding|
|long-term synaptic depression|
|positive regulation of amino acid transport|
|calcium ion-regulated exocytosis of neurotransmitter|
|positive regulation of calcium ion-dependent exocytosis|
|regulation of acrosome reaction|
|positive regulation of mast cell activation|
|positive regulation of neurotransmitter secretion|
|positive regulation of leukocyte degranulation|
|syntaxin-1 binding|
|regulation of fertilization|
|glutamate secretion|
|positive regulation of myeloid leukocyte mediated immunity|
|regulation of amino acid transport|
|regulation of vesicle fusion|
|positive regulation of synaptic transmission, glutamatergic|
|regulation of synaptic transmission, GABAergic|
|neuromuscular synaptic transmission|
|positive regulation of organic acid transport|
|regulation of mast cell degranulation|
|regulation of mast cell activation involved in immune response|
|positive regulation of amine transport|
|positive regulation of neurotransmitter transport|
|calcium-ion regulated exocytosis|
|vesicle docking involved in exocytosis|
|regulation of calcium ion-dependent exocytosis|
|platelet aggregation|
|regulation of mast cell activation|
|acidic amino acid transport|
|regulation of leukocyte degranulation|
|positive regulation of anion transport|
|positive regulation of regulated secretory pathway|
|syntaxin binding|
|regulation of myeloid leukocyte mediated immunity|
|regulation of organic acid transport|
|homotypic cell-cell adhesion|
|phagocytic vesicle|
|negative regulation of synaptic transmission|
|vesicle docking|
|synaptic vesicle exocytosis|
|SNARE binding|
|exocytic process|
|regulation of synaptic transmission, glutamatergic|
|vesicle fusion|
|organelle membrane fusion|
|regulation of synaptic vesicle exocytosis|
|dicarboxylic acid transport|
|acid secretion|
|postsynapse|
|positive regulation of exocytosis|
|regulation of amine transport|
|regulation of anion transport|
|organelle fusion|
|signal release from synapse|
|neurotransmitter secretion|
|regulation of neurotransmitter secretion|
|protein N-terminus binding|
|regulation of synaptic vesicle cycle|
|synaptic vesicle cycle|
|amino acid transport|
|platelet degranulation|
|vesicle-mediated transport in synapse|
|negative regulation of protein complex assembly|
|membrane fusion|
|positive regulation of leukocyte mediated immunity|
|response to estradiol|
|platelet activation|
|regulation of neurotransmitter transport|
|negative regulation of neuron apoptotic process|
|positive regulation of synaptic transmission|
|regulation of reproductive process|
|cellular response to interferon-gamma|
|regulation of regulated secretory pathway|
|signal release|
|organelle localization by membrane tethering|
|protein stabilization|
|membrane docking|
|neurotransmitter transport|
|response to interferon-gamma|
|protein localization to plasma membrane|
|regulation of synaptic plasticity|
|regulation of leukocyte mediated immunity|
|negative regulation of neuron death|
|regulation of neuron apoptotic process|
|positive regulation of intracellular transport|
|positive regulation of immune effector process|
|regulation of exocytosis|
|protein localization to cell periphery|
|developmental maturation|
|protein domain specific binding|
|positive regulation of ion transport|
|regulation of protein stability|
|carboxylic acid transport|
|organic acid transport|
|blood coagulation|
|coagulation|
|axon|
|hemostasis|
|vesicle organization|
|regulation of neuron death|
|glutamatergic synapse|
|regulation of intracellular transport|
|regulation of neurotransmitter levels|
|cytoskeleton|
|axonogenesis|
|positive regulation of secretion by cell|
|positive regulation of leukocyte activation|
|axon development|
|positive regulation of cell activation|
|anterograde trans-synaptic signaling|
|chemical synaptic transmission|
|cell morphogenesis involved in neuron differentiation|
|positive regulation of secretion|
|trans-synaptic signaling|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|regulation of protein complex assembly|
|organic anion transport|
|synaptic signaling|
|protein kinase binding|
|regulation of immune effector process|
|wound healing|
|protein localization to membrane|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|regulation of body fluid levels|
|cell-cell adhesion|
|cell part morphogenesis|
|regulation of vesicle-mediated transport|
|cell morphogenesis involved in differentiation|
|response to wounding|
|organelle localization|
|anion transport|
|protein-containing complex|
|regulation of leukocyte activation|
|regulation of cell activation|
|neuron projection development|
|developmental process involved in reproduction|
|perinuclear region of cytoplasm|
|regulation of ion transport|
|regulated exocytosis|
|negative regulation of cellular component organization|
|cell morphogenesis|
|regulation of secretion by cell|
|innate immune response|
|regulation of multi-organism process|
|exocytosis|
|regulation of secretion|
|neuron development|
|cellular component morphogenesis|
|cellular protein-containing complex assembly|
|response to lipid|
|membrane organization|
|positive regulation of immune response|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|response to hormone|
|regulation of cellular localization|
|response to organic cyclic compound|
|cell adhesion|
|biological adhesion|
|defense response to other organism|
|regulation of cellular component biogenesis|
|positive regulation of transport|
|negative regulation of cell death|
|secretion by cell|
|cellular response to cytokine stimulus|
|neuron differentiation|
|export from cell|
|identical protein binding|
|cell activation|
|response to cytokine|
|cell-cell signaling|
|plasma membrane bounded cell projection organization|
|secretion|
|regulation of immune response|
|positive regulation of immune system process|
|cell projection organization|
|mitochondrion|
|regulation of organelle organization|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|ion transport|
|RNA binding|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|protein transport|
|generation of neurons|
|peptide transport|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|regulation of programmed cell death|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|neurogenesis|
|cell development|
|regulation of immune system process|
|regulation of cell death|
|positive regulation of cell communication|
|positive regulation of signaling|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|regulation of transport|
|immune response|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp280|Daidzin 10μM R06 exp280]]|-2.43|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|-1.81|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|1/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10981
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.93 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='STXBP1 Expression in NALM6 Cells: 3.93'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>