SUCNR1 [The Human Chemical-Genetic Interaction Map Project]

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======= SUCNR1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SUCNR1
  * **<color #00a2e8>Official Name</color>**: succinate receptor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=56670|56670]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BXA5|Q9BXA5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SUCNR1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SUCNR1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606381|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for succinate. {ECO:0000269|PubMed:15141213}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7tm 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of angiotensin metabolic process|
|renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure|
|renin secretion into blood stream|
|macrophage activation involved in immune response|
|interleukin-1 beta production|
|regulation of systemic arterial blood pressure by circulatory renin-angiotensin|
|interleukin-1 production|
|regulation of systemic arterial blood pressure by renin-angiotensin|
|renal system process involved in regulation of systemic arterial blood pressure|
|regulation of systemic arterial blood pressure by hormone|
|regulation of systemic arterial blood pressure mediated by a chemical signal|
|endocrine process|
|macrophage activation|
|regulation of systemic arterial blood pressure|
|renal system process|
|positive regulation of chemotaxis|
|positive regulation of inflammatory response|
|cytokine production|
|response to calcium ion|
|protein secretion|
|establishment of protein localization to extracellular region|
|protein localization to extracellular region|
|peptide secretion|
|regulation of blood pressure|
|glucose homeostasis|
|carbohydrate homeostasis|
|regulation of chemotaxis|
|regulation of inflammatory response|
|response to metal ion|
|blood circulation|
|circulatory system process|
|positive regulation of defense response|
|myeloid cell activation involved in immune response|
|response to inorganic substance|
|positive regulation of locomotion|
|myeloid leukocyte activation|
|positive regulation of response to external stimulus|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|G protein-coupled receptor activity|
|regulation of defense response|
|leukocyte activation|
|regulation of locomotion|
|secretion by cell|
|export from cell|
|cell activation|
|immune effector process|
|regulation of response to external stimulus|
|chemical homeostasis|
|secretion|
|G protein-coupled receptor signaling pathway|
|regulation of response to stress|
|protein transport|
|peptide transport|
|amide transport|
|establishment of protein localization|
|homeostatic process|
|nitrogen compound transport|
|immune response|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp438|NN-Diethyl-meta-toluamide 500μM R08 exp438]]|1.74|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|2.14|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18150
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.28 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SUCNR1 Expression in NALM6 Cells: -3.28'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>