SUGP1 [The Human Chemical-Genetic Interaction Map Project]

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======= SUGP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SUGP1
  * **<color #00a2e8>Official Name</color>**: SURP and G-patch domain containing 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57794|57794]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8IWZ8|Q8IWZ8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SUGP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SUGP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607992|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in pre-mRNA splicing.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Surp|
|G-patch 2|
|G-patch|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|spliceosomal complex|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|RNA splicing, via transesterification reactions|
|RNA splicing|
|mRNA processing|
|mRNA metabolic process|
|RNA processing|
|RNA binding|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp16|DABN 2μM R00 exp16]]|1.77|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|1.81|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|1.83|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|1.87|
|[[:results:exp220|BAY-598 4μM R05 exp220]]|1.89|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|1.92|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|1.98|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|2.17|
|[[:results:exp273|Cisplatin 0.35μM R06 exp273]]|2.44|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 174/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|7/28|
|blood|3/28|
|bone|7/26|
|breast|10/33|
|central nervous system|6/56|
|cervix|1/4|
|colorectal|6/17|
|esophagus|2/13|
|fibroblast|0/1|
|gastric|6/16|
|kidney|4/21|
|liver|6/20|
|lung|17/75|
|lymphocyte|5/16|
|ovary|4/26|
|pancreas|7/24|
|peripheral nervous system|2/16|
|plasma cell|3/15|
|prostate|0/1|
|skin|6/24|
|soft tissue|3/9|
|thyroid|1/2|
|upper aerodigestive|8/22|
|urinary tract|9/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 843
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.12 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SUGP1 Expression in NALM6 Cells: 5.12'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>