SULT2B1 [The Human Chemical-Genetic Interaction Map Project]

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======= SULT2B1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SULT2B1
  * **<color #00a2e8>Official Name</color>**: sulfotransferase family 2B member 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6820|6820]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O00204|O00204]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SULT2B1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SULT2B1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604125|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene sulfates dehydroepiandrosterone but not 4-nitrophenol, a typical substrate for the phenol and estrogen sulfotransferase subfamilies. Two alternatively spliced variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates hydroxysteroids like DHEA. Isoform 1 preferentially sulfonates cholesterol, and isoform 2 avidly sulfonates pregnenolone but not cholesterol. Plays a role in epidermal cholesterol metabolism and in the regulation of epidermal proliferation and differentiation (PubMed:28575648). {ECO:0000269|PubMed:12145317, ECO:0000269|PubMed:28575648, ECO:0000269|PubMed:9799594}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Sulfotransfer 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|alcohol sulfotransferase activity|
|sulfate assimilation|
|steroid sulfotransferase activity|
|steroid hormone binding|
|3-phosphoadenosine 5-phosphosulfate metabolic process|
|positive regulation of epidermal cell differentiation|
|purine ribonucleoside bisphosphate metabolic process|
|positive regulation of epidermis development|
|cholesterol binding|
|positive regulation of epithelial cell differentiation|
|regulation of epidermal cell differentiation|
|regulation of epidermis development|
|cholesterol metabolic process|
|secondary alcohol metabolic process|
|purine nucleoside bisphosphate metabolic process|
|nucleoside bisphosphate metabolic process|
|ribonucleoside bisphosphate metabolic process|
|sterol metabolic process|
|regulation of epithelial cell differentiation|
|nucleic acid binding|
|steroid metabolic process|
|purine ribonucleotide metabolic process|
|alcohol metabolic process|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|sulfur compound metabolic process|
|purine-containing compound metabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|organic hydroxy compound metabolic process|
|nucleobase-containing small molecule metabolic process|
|negative regulation of cell population proliferation|
|intracellular membrane-bounded organelle|
|organophosphate metabolic process|
|positive regulation of cell differentiation|
|oxoacid metabolic process|
|endoplasmic reticulum|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|lipid metabolic process|
|positive regulation of developmental process|
|regulation of cell population proliferation|
|small molecule metabolic process|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|-1.75|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|2.13|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:supt6h|SUPT6H]]|0.488|
|[[:human genes:t:tfip11|TFIP11]]|0.478|
|[[:human genes:c:cdc6|CDC6]]|0.477|
|[[:human genes:d:dtl|DTL]]|0.453|
|[[:human genes:o:or10g3|OR10G3]]|0.453|
|[[:human genes:p:prim1|PRIM1]]|0.445|
|[[:human genes:h:hist2h2bf|HIST2H2BF]]|0.435|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.434|
|[[:human genes:n:nsf|NSF]]|0.433|
|[[:human genes:z:zfand5|ZFAND5]]|0.428|
|[[:human genes:r:rps2|RPS2]]|0.427|
|[[:human genes:n:nol10|NOL10]]|0.426|
|[[:human genes:n:nupl1|NUPL1]]|0.425|
|[[:human genes:p:pcf11|PCF11]]|0.425|
|[[:human genes:t:ticrr|TICRR]]|0.423|
|[[:human genes:c:ctage4|CTAGE4]]|0.418|
|[[:human genes:s:snip1|SNIP1]]|0.417|
|[[:human genes:t:tceb3c|TCEB3C]]|0.417|
|[[:human genes:h:hivep3|HIVEP3]]|0.416|
|[[:human genes:s:sec13|SEC13]]|0.416|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.415|
|[[:human genes:s:syt9|SYT9]]|0.412|
|[[:human genes:s:supt5h|SUPT5H]]|0.41|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.41|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.41|
|[[:human genes:r:rpl14|RPL14]]|0.409|
|[[:human genes:p:psma6|PSMA6]]|0.407|
|[[:human genes:o:orc6|ORC6]]|0.407|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.407|
|[[:human genes:a:aatf|AATF]]|0.406|
|[[:human genes:c:cactin|CACTIN]]|0.404|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.404|
|[[:human genes:s:ssh2|SSH2]]|0.402|
|[[:human genes:g:gar1|GAR1]]|0.401|
|[[:human genes:n:nup62|NUP62]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2412
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.53 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SULT2B1 Expression in NALM6 Cells: 0.53'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>