SUPT20H [The Human Chemical-Genetic Interaction Map Project]

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======= SUPT20H =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SUPT20H
  * **<color #00a2e8>Official Name</color>**: SPT20 homolog, SAGA complex component
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55578|55578]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8NEM7|Q8NEM7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SUPT20H&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SUPT20H|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613417|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) activation during gastrulation. Required for down- regulation of E-cadherin during gastrulation by regulating E- cadherin protein level downstream from NCK-interacting kinase (NIK) and independently of the regulation of transcription by FGF signaling and Snail (By similarity). Required for starvation- induced ATG9A trafficking during autophagy. {ECO:0000250, ECO:0000269|PubMed:19893488}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Spt20|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|SAGA-type complex|
|SAGA complex|
|transcription coregulator activity|
|fibrillar center|
|gastrulation|
|process utilizing autophagic mechanism|
|autophagy|
|embryonic morphogenesis|
|embryo development|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|-1.83|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|-1.81|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-1.8|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|1.98|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|2.12|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|2.19|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|2.23|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|2.43|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|3.17|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:taf6l|TAF6L]]|0.568|
|[[:human genes:t:tada1|TADA1]]|0.547|
|[[:human genes:t:tada2b|TADA2B]]|0.517|
|[[:human genes:s:supt7l|SUPT7L]]|0.487|
|[[:human genes:t:taf5l|TAF5L]]|0.479|
|[[:human genes:c:ccdc101|CCDC101]]|0.473|
|[[:human genes:t:tada3|TADA3]]|0.432|
|[[:human genes:m:med13|MED13]]|0.431|
|[[:human genes:m:mllt1|MLLT1]]|0.422|
|[[:human genes:s:smarcd1|SMARCD1]]|0.41|
|[[:human genes:t:tle4|TLE4]]|0.408|
|[[:human genes:m:med23|MED23]]|0.408|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 12/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|2/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|1/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|3/15|
|prostate|1/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|1/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1846
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.29 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SUPT20H Expression in NALM6 Cells: 6.29'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>