SURF1 [The Human Chemical-Genetic Interaction Map Project]

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======= SURF1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SURF1
  * **<color #00a2e8>Official Name</color>**: SURF1 cytochrome c oxidase assembly factor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6834|6834]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15526|Q15526]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SURF1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SURF1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/185620|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein localized to the inner mitochondrial membrane and thought to be involved in the biogenesis of the cytochrome c oxidase complex. The protein is a member of the SURF1 family, which includes the related yeast protein SHY1 and rickettsial protein RP733. The gene is located in the surfeit gene cluster, a group of very tightly linked genes that do not share sequence similarity, where it shares a bidirectional promoter with SURF2 on the opposite strand. Defects in this gene are a cause of Leigh syndrome, a severe neurological disorder that is commonly associated with systemic cytochrome c oxidase deficiency. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. {ECO:0000269|PubMed:24027061, ECO:0000269|PubMed:9843204, ECO:0000305|PubMed:26321642}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SURF1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial respirasome|
|mitochondrial respiratory chain complex IV assembly|
|respiratory chain complex IV assembly|
|cytochrome-c oxidase activity|
|cytochrome complex assembly|
|aerobic respiration|
|mitochondrial respiratory chain complex assembly|
|oxidative phosphorylation|
|proton transmembrane transport|
|cellular respiration|
|electron transport chain|
|ATP metabolic process|
|energy derivation by oxidation of organic compounds|
|monovalent inorganic cation transport|
|generation of precursor metabolites and energy|
|mitochondrion organization|
|inorganic cation transmembrane transport|
|cation transmembrane transport|
|inorganic ion transmembrane transport|
|cation transport|
|cellular protein-containing complex assembly|
|ion transmembrane transport|
|oxidation-reduction process|
|transmembrane transport|
|phosphorylation|
|ion transport|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|-2.03|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|-1.7|
|[[:results:exp453|B02 10μM R08 exp453]]|1.78|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|1.95|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|1.96|
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|2.19|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.24|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:cox8a|COX8A]]|0.546|
|[[:human genes:m:mrpl16|MRPL16]]|0.431|
|[[:human genes:c:cox6a1|COX6A1]]|0.415|
|[[:human genes:p:pet117|PET117]]|0.414|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1663
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.99 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SURF1 Expression in NALM6 Cells: 4.99'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>