SWI5 [The Human Chemical-Genetic Interaction Map Project]

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======= SWI5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SWI5
  * **<color #00a2e8>Official Name</color>**: SWI5 homologous recombination repair protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=375757|375757]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q1ZZU3|Q1ZZU3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SWI5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SWI5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616528|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination. {ECO:0000269|PubMed:21252223}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Swi5|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Swi5-Sfr1 complex|
|DNA recombinase assembly|
|DNA repair complex assembly|
|double-strand break repair via synthesis-dependent strand annealing|
|cellular response to ionizing radiation|
|double-strand break repair via homologous recombination|
|recombinational repair|
|response to ionizing radiation|
|cellular response to radiation|
|double-strand break repair|
|protein-DNA complex assembly|
|DNA recombination|
|protein-DNA complex subunit organization|
|cellular response to abiotic stimulus|
|cellular response to environmental stimulus|
|response to radiation|
|DNA repair|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|cellular protein-containing complex assembly|
|response to abiotic stimulus|
|protein-containing complex assembly|
|cellular response to stress|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|-2.75|
|[[:results:exp270|Campthothecin 0.001μM R06 exp270]]|-2.72|
|[[:results:exp292|Menadione 5μM R06 exp292]]|-2.56|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|-2.55|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|-2.54|
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|-2.51|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-2.43|
|[[:results:exp360|Genistein 15μM R07 exp360]]|-2.36|
|[[:results:exp326|CCT251545 20μM R07 exp326]]|-2.27|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|-2.15|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|-2.09|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|-2.08|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|-2|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|-1.9|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|-1.86|
|[[:results:exp261|ABT-702 5μM R06 exp261]]|-1.85|
|[[:results:exp246|UM0011500 10μM R05 exp246]]|-1.84|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-1.81|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|-1.78|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|-1.77|
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|-1.73|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|-1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mad2l2|MAD2L2]]|0.433|
|[[:human genes:c:c17orf53|C17orf53]]|0.423|
|[[:human genes:m:mcm9|MCM9]]|0.416|
|[[:human genes:r:rad51b|RAD51B]]|0.415|
|[[:human genes:s:swsap1|SWSAP1]]|0.405|
|[[:human genes:s:sfr1|SFR1]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4082
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.8 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SWI5 Expression in NALM6 Cells: 2.8'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>