SWSAP1 [The Human Chemical-Genetic Interaction Map Project]

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======= SWSAP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SWSAP1
  * **<color #00a2e8>Official Name</color>**: SWIM-type zinc finger 7 associated protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=126074|126074]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6NVH7|Q6NVH7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SWSAP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SWSAP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614536|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  ATPase which is preferentially stimulated by single- stranded DNA and is involved in homologous recombination repair (HRR). Has a DNA-binding activity which is independent of its ATPase activity. {ECO:0000269|PubMed:21965664}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Shu complex|
|double-strand break repair via homologous recombination|
|recombinational repair|
|single-stranded DNA binding|
|protein stabilization|
|double-strand break repair|
|DNA recombination|
|ATPase activity|
|regulation of protein stability|
|DNA repair|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|cellular response to stress|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-3.85|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|-3.62|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|-2.96|
|[[:results:exp270|Campthothecin 0.001μM R06 exp270]]|-2.7|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|-2.29|
|[[:results:exp360|Genistein 15μM R07 exp360]]|-1.89|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|-1.81|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|2.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:spidr|SPIDR]]|0.546|
|[[:human genes:z:zswim7|ZSWIM7]]|0.528|
|[[:human genes:h:h2afx|H2AFX]]|0.462|
|[[:human genes:s:sfr1|SFR1]]|0.449|
|[[:human genes:r:rnf168|RNF168]]|0.441|
|[[:human genes:m:mcm9|MCM9]]|0.439|
|[[:human genes:r:rnf8|RNF8]]|0.421|
|[[:human genes:s:swi5|SWI5]]|0.405|
|[[:human genes:r:rad54l|RAD54L]]|0.405|
|[[:human genes:a:apitd1|APITD1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9640
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.64 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SWSAP1 Expression in NALM6 Cells: 2.64'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>