SYF2 [The Human Chemical-Genetic Interaction Map Project]

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======= SYF2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SYF2
  * **<color #00a2e8>Official Name</color>**: SYF2 pre-mRNA splicing factor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=25949|25949]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95926|O95926]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SYF2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SYF2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607090|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May be involved in pre-mRNA splicing. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SYF2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|post-mRNA release spliceosomal complex|
|Prp19 complex|
|mitotic G2 DNA damage checkpoint|
|mitotic G2/M transition checkpoint|
|G2 DNA damage checkpoint|
|U2-type catalytic step 2 spliceosome|
|catalytic step 2 spliceosome|
|negative regulation of G2/M transition of mitotic cell cycle|
|mitotic DNA damage checkpoint|
|negative regulation of cell cycle G2/M phase transition|
|mitotic DNA integrity checkpoint|
|DNA damage checkpoint|
|DNA integrity checkpoint|
|mitotic cell cycle checkpoint|
|gastrulation|
|cell cycle checkpoint|
|regulation of G2/M transition of mitotic cell cycle|
|regulation of cell cycle G2/M phase transition|
|negative regulation of mitotic cell cycle phase transition|
|negative regulation of cell cycle phase transition|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions|
|negative regulation of mitotic cell cycle|
|negative regulation of cell cycle process|
|in utero embryonic development|
|RNA splicing|
|nuclear speck|
|regulation of mitotic cell cycle phase transition|
|embryonic organ development|
|regulation of cell cycle phase transition|
|mRNA processing|
|embryonic morphogenesis|
|negative regulation of cell cycle|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|mitotic cell cycle|
|mRNA metabolic process|
|regulation of cell cycle process|
|cellular response to DNA damage stimulus|
|RNA processing|
|positive regulation of cell population proliferation|
|embryo development|
|cell cycle process|
|regulation of cell cycle|
|cell cycle|
|RNA binding|
|regulation of cell population proliferation|
|RNA metabolic process|
|cellular response to stress|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|1.71|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|1.92|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:prim1|PRIM1]]|0.45|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 569/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|21/28|
|blood|19/28|
|bone|13/26|
|breast|27/33|
|central nervous system|40/56|
|cervix|4/4|
|colorectal|15/17|
|esophagus|11/13|
|fibroblast|1/1|
|gastric|11/16|
|kidney|16/21|
|liver|14/20|
|lung|61/75|
|lymphocyte|12/16|
|ovary|24/26|
|pancreas|16/24|
|peripheral nervous system|13/16|
|plasma cell|10/15|
|prostate|1/1|
|skin|16/24|
|soft tissue|9/9|
|thyroid|1/2|
|upper aerodigestive|19/22|
|urinary tract|23/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1439
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.9 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SYF2 Expression in NALM6 Cells: 4.9'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>