SYK [The Human Chemical-Genetic Interaction Map Project]

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======= SYK =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SYK
  * **<color #00a2e8>Official Name</color>**: spleen associated tyrosine kinase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6850|6850]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P43405|P43405]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SYK&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SYK|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600085|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine- phosphorylated ITAM domains. The association with the receptor can also be indirect and mediated by adapter proteins containing ITAM or partial hemITAM domains. The phosphorylation of the ITAM domains is generally mediated by SRC subfamily kinases upon engagement of the receptor. More rarely signal transduction via SYK could be ITAM-independent. Direct downstream effectors phosphorylated by SYK include VAV1, PLCG1, PI-3-kinase, LCP2 and BLNK. Initially identified as essential in B-cell receptor (BCR) signaling, it is necessary for the maturation of B-cells most probably at the pro-B to pre-B transition. Activated upon BCR engagement, it phosphorylates and activates BLNK an adapter linking the activated BCR to downstream signaling adapters and effectors. It also phosphorylates and activates PLCG1 and the PKC signaling pathway. It also phosphorylates BTK and regulates its activity in B-cell antigen receptor (BCR)-coupled signaling. In addition to its function downstream of BCR plays also a role in T- cell receptor signaling. Plays also a crucial role in the innate immune response to fungal, bacterial and viral pathogens. It is for instance activated by the membrane lectin CLEC7A. Upon stimulation by fungal proteins, CLEC7A together with SYK activates immune cells inducing the production of ROS. Also activates the inflammasome and NF-kappa-B-mediated transcription of chemokines and cytokines in presence of pathogens. Regulates neutrophil degranulation and phagocytosis through activation of the MAPK signaling cascade. Also mediates the activation of dendritic cells by cell necrosis stimuli. Also involved in mast cells activation. Also functions downstream of receptors mediating cell adhesion. Relays for instance, integrin-mediated neutrophils and macrophages activation and P-selectin receptor/SELPG-mediated recruitment of leukocytes to inflammatory loci. Plays also a role in non-immune processes. It is for instance involved in vascular development where it may regulate blood and lymphatic vascular separation. It is also required for osteoclast development and function. Functions in the activation of platelets by collagen, mediating PLCG2 phosphorylation and activation. May be coupled to the collagen receptor by the ITAM domain-containing FCER1G. Also activated by the membrane lectin CLEC1B that is required for activation of platelets by PDPN/podoplanin. Involved in platelet adhesion being activated by ITGB3 engaged by fibrinogen. Together with CEACAM20, enhances production of the cytokine CXCL8/IL-8 via the NFKB pathway and may thus have a role in the intestinal immune response (By similarity). {ECO:0000250|UniProtKB:P48025, ECO:0000269|PubMed:12387735, ECO:0000269|PubMed:12456653, ECO:0000269|PubMed:15388330, ECO:0000269|PubMed:19909739, ECO:0000269|PubMed:8657103, ECO:0000269|PubMed:9535867}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase Tyr|
|SH2|
|Pkinase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of interleukin-3 biosynthetic process|
|positive regulation of interleukin-3 production|
|interleukin-15 receptor binding|
|positive regulation of interleukin-3 biosynthetic process|
|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process|
|regulation of interleukin-3 production|
|positive regulation of gamma-delta T cell differentiation|
|serotonin secretion|
|serotonin production involved in inflammatory response|
|beta selection|
|cellular response to molecule of fungal origin|
|serotonin secretion by platelet|
|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process|
|serotonin secretion involved in inflammatory response|
|response to molecule of fungal origin|
|positive regulation of interleukin-10 biosynthetic process|
|B cell receptor complex|
|regulation of gamma-delta T cell differentiation|
|positive regulation of gamma-delta T cell activation|
|interleukin-3-mediated signaling pathway|
|Toll-like receptor binding|
|regulation of interleukin-10 biosynthetic process|
|serotonin transport|
|positive regulation of interleukin-12 biosynthetic process|
|regulation of gamma-delta T cell activation|
|regulation of neutrophil degranulation|
|regulation of arachidonic acid secretion|
|regulation of interleukin-12 biosynthetic process|
|collagen-activated tyrosine kinase receptor signaling pathway|
|positive regulation of monocyte chemotactic protein-1 production|
|early phagosome|
|regulation of neutrophil activation|
|interleukin-2-mediated signaling pathway|
|positive regulation of interleukin-8 biosynthetic process|
|cellular response to interleukin-2|
|positive regulation of B cell differentiation|
|macrophage activation involved in immune response|
|response to interleukin-2|
|positive regulation of granulocyte macrophage colony-stimulating factor production|
|collagen-activated signaling pathway|
|positive regulation of killing of cells of other organism|
|positive regulation of mast cell degranulation|
|positive regulation of mast cell activation involved in immune response|
|positive regulation of interleukin-6 biosynthetic process|
|regulation of granulocyte macrophage colony-stimulating factor production|
|regulation of interleukin-8 biosynthetic process|
|regulation of monocyte chemotactic protein-1 production|
|production of molecular mediator involved in inflammatory response|
|regulation of killing of cells of other organism|
|positive regulation of bone resorption|
|positive regulation of bone remodeling|
|regulation of platelet aggregation|
|cellular response to low-density lipoprotein particle stimulus|
|positive regulation of alpha-beta T cell proliferation|
|positive regulation of superoxide anion generation|
|regulation of icosanoid secretion|
|leukotriene biosynthetic process|
|positive regulation of cell adhesion mediated by integrin|
|positive regulation of mast cell activation|
|positive regulation of tumor necrosis factor biosynthetic process|
|monoamine transport|
|lymph vessel development|
|regulation of superoxide anion generation|
|regulation of interleukin-6 biosynthetic process|
|positive regulation of interleukin-4 production|
|positive regulation of leukocyte degranulation|
|regulation of homotypic cell-cell adhesion|
|positive regulation of receptor internalization|
|response to lipoprotein particle|
|regulation of B cell differentiation|
|regulation of fatty acid transport|
|regulation of interleukin-4 production|
|cellular response to lipoprotein particle stimulus|
|regulation of tumor necrosis factor biosynthetic process|
|regulation of alpha-beta T cell proliferation|
|leukotriene metabolic process|
|positive regulation of tissue remodeling|
|regulation of platelet activation|
|positive regulation of myeloid leukocyte mediated immunity|
|regulation of superoxide metabolic process|
|regulation of mast cell degranulation|
|positive regulation of interleukin-12 production|
|regulation of mast cell activation involved in immune response|
|positive regulation of interleukin-10 production|
|SH2 domain binding|
|activation of JUN kinase activity|
|T cell selection|
|phosphotyrosine residue binding|
|regulation of bone resorption|
|positive regulation of calcium-mediated signaling|
|regulation of mast cell activation|
|positive regulation of alpha-beta T cell differentiation|
|icosanoid biosynthetic process|
|regulation of cell adhesion mediated by integrin|
|non-membrane spanning protein tyrosine kinase activity|
|regulation of bone remodeling|
|positive regulation of interleukin-8 production|
|phosphatase binding|
|regulation of leukocyte degranulation|
|response to fungus|
|alpha-beta T cell differentiation|
|macrophage activation|
|leukocyte cell-cell adhesion|
|regulation of interleukin-10 production|
|ammonium transport|
|positive regulation of receptor-mediated endocytosis|
|positive regulation of regulated secretory pathway|
|regulation of interleukin-12 production|
|regulation of receptor internalization|
|positive regulation of chemokine production|
|regulation of tumor necrosis factor-mediated signaling pathway|
|regulation of organic acid transport|
|regulation of myeloid leukocyte mediated immunity|
|positive regulation of alpha-beta T cell activation|
|alpha-beta T cell activation|
|regulation of alpha-beta T cell differentiation|
|receptor internalization|
|positive regulation of cell killing|
|positive regulation of cytokine biosynthetic process|
|exocytic process|
|regulation of interleukin-8 production|
|positive regulation of JUN kinase activity|
|regulation of tissue remodeling|
|regulation of chemokine production|
|positive regulation of type I interferon production|
|regulation of blood coagulation|
|regulation of hemostasis|
|JNK cascade|
|positive regulation of T cell differentiation|
|regulation of coagulation|
|neutrophil chemotaxis|
|positive regulation of tumor necrosis factor production|
|regulation of JUN kinase activity|
|positive regulation of tumor necrosis factor superfamily cytokine production|
|protein tyrosine kinase activity|
|positive regulation of exocytosis|
|granulocyte chemotaxis|
|neutrophil migration|
|fatty acid derivative biosynthetic process|
|regulation of alpha-beta T cell activation|
|integrin-mediated signaling pathway|
|positive regulation of lymphocyte differentiation|
|positive regulation of interleukin-6 production|
|positive regulation of T cell proliferation|
|protein import into nucleus|
|positive regulation of reactive oxygen species metabolic process|
|regulation of anion transport|
|regulation of phagocytosis|
|regulation of calcium-mediated signaling|
|positive regulation of cold-induced thermogenesis|
|positive regulation of endocytosis|
|regulation of receptor-mediated endocytosis|
|granulocyte migration|
|regulation of cell killing|
|regulation of cytokine biosynthetic process|
|receptor metabolic process|
|stress-activated MAPK cascade|
|regulation of lipid transport|
|icosanoid metabolic process|
|stimulatory C-type lectin receptor signaling pathway|
|import into nucleus|
|innate immune response activating cell surface receptor signaling pathway|
|regulation of type I interferon production|
|myeloid leukocyte migration|
|B cell receptor signaling pathway|
|T cell receptor complex|
|platelet degranulation|
|positive regulation of lymphocyte proliferation|
|integrin binding|
|positive regulation of mononuclear cell proliferation|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|positive regulation of leukocyte mediated immunity|
|T cell differentiation|
|immune response-regulating cell surface receptor signaling pathway involved in phagocytosis|
|Fc-gamma receptor signaling pathway involved in phagocytosis|
|positive regulation of leukocyte proliferation|
|Fc receptor mediated stimulatory signaling pathway|
|regulation of T cell differentiation|
|regulation of wound healing|
|platelet activation|
|organic hydroxy compound transport|
|regulation of lipid localization|
|positive regulation of JNK cascade|
|Fc-gamma receptor signaling pathway|
|positive regulation of cytokine secretion|
|regulation of interleukin-6 production|
|stress-activated protein kinase signaling cascade|
|protein import|
|peptidyl-tyrosine phosphorylation|
|regulation of cold-induced thermogenesis|
|leukocyte chemotaxis|
|peptidyl-tyrosine modification|
|positive regulation of leukocyte differentiation|
|regulation of tumor necrosis factor production|
|positive regulation of cysteine-type endopeptidase activity|
|regulation of tumor necrosis factor superfamily cytokine production|
|activation of MAPK activity|
|regulation of T cell proliferation|
|protein localization to nucleus|
|regulation of cytokine-mediated signaling pathway|
|regulation of regulated secretory pathway|
|positive regulation of B cell activation|
|regulation of response to wounding|
|positive regulation of stress-activated MAPK cascade|
|fatty acid derivative metabolic process|
|regulation of lymphocyte differentiation|
|positive regulation of stress-activated protein kinase signaling cascade|
|positive regulation of endopeptidase activity|
|Fc-epsilon receptor signaling pathway|
|peptidyl-serine phosphorylation|
|regulation of response to cytokine stimulus|
|neurotransmitter transport|
|regulation of reactive oxygen species metabolic process|
|regulation of JNK cascade|
|positive regulation of hemopoiesis|
|positive regulation of peptidyl-tyrosine phosphorylation|
|positive regulation of peptidase activity|
|protein autophosphorylation|
|peptidyl-serine modification|
|positive regulation of T cell activation|
|regulation of cytokine secretion|
|regulation of endocytosis|
|regulation of leukocyte mediated immunity|
|positive regulation of intracellular transport|
|regulation of B cell activation|
|regulation of lymphocyte proliferation|
|cell chemotaxis|
|regulation of mononuclear cell proliferation|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|cellular response to biotic stimulus|
|positive regulation of leukocyte cell-cell adhesion|
|positive regulation of immune effector process|
|regulation of leukocyte proliferation|
|regulation of exocytosis|
|innate immune response-activating signal transduction|
|regulation of stress-activated MAPK cascade|
|T cell activation|
|regulation of stress-activated protein kinase signaling cascade|
|lymphocyte differentiation|
|receptor-mediated endocytosis|
|protein kinase activity|
|Fc receptor signaling pathway|
|regulation of cysteine-type endopeptidase activity|
|positive regulation of protein complex assembly|
|regulation of peptidyl-tyrosine phosphorylation|
|positive regulation of cell-cell adhesion|
|activation of innate immune response|
|positive regulation of MAP kinase activity|
|nucleocytoplasmic transport|
|nuclear transport|
|positive regulation of protein secretion|
|regulation of leukocyte differentiation|
|positive regulation of peptide secretion|
|blood coagulation|
|regulation of ERK1 and ERK2 cascade|
|antigen receptor-mediated signaling pathway|
|coagulation|
|regulation of leukocyte cell-cell adhesion|
|hemostasis|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|regulation of T cell activation|
|angiogenesis|
|activation of protein kinase activity|
|phagocytosis|
|defense response to bacterium|
|leukocyte differentiation|
|positive regulation of protein serine/threonine kinase activity|
|positive regulation of innate immune response|
|regulation of MAP kinase activity|
|regulation of intracellular transport|
|positive regulation of proteolysis|
|positive regulation of lymphocyte activation|
|positive regulation of response to biotic stimulus|
|protein serine/threonine kinase activity|
|MAPK cascade|
|leukocyte migration|
|lymphocyte activation|
|signal transduction by protein phosphorylation|
|regulation of cell-cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of secretion by cell|
|positive regulation of cell adhesion|
|blood vessel morphogenesis|
|positive regulation of cell activation|
|regulation of endopeptidase activity|
|positive regulation of protein transport|
|regulation of DNA-binding transcription factor activity|
|establishment of protein localization to organelle|
|positive regulation of secretion|
|regulation of peptidase activity|
|positive regulation of cytokine production|
|immune response-activating cell surface receptor signaling pathway|
|regulation of hemopoiesis|
|regulation of protein complex assembly|
|regulation of innate immune response|
|positive regulation of establishment of protein localization|
|protein kinase binding|
|regulation of protein secretion|
|regulation of immune effector process|
|positive regulation of defense response|
|wound healing|
|immune response-regulating cell surface receptor signaling pathway|
|blood vessel development|
|neutrophil activation involved in immune response|
|regulation of peptide secretion|
|regulation of body fluid levels|
|inflammatory response|
|neutrophil activation|
|cell-cell adhesion|
|granulocyte activation|
|positive regulation of multi-organism process|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|vasculature development|
|regulation of lymphocyte activation|
|regulation of protein serine/threonine kinase activity|
|cardiovascular system development|
|positive regulation of cellular component biogenesis|
|regulation of response to biotic stimulus|
|myeloid cell activation involved in immune response|
|positive regulation of protein kinase activity|
|positive regulation of MAPK cascade|
|regulation of vesicle-mediated transport|
|chemotaxis|
|taxis|
|endocytosis|
|hemopoiesis|
|immune response-activating signal transduction|
|response to wounding|
|positive regulation of kinase activity|
|myeloid leukocyte activation|
|small molecule biosynthetic process|
|protein-containing complex|
|immune response-regulating signaling pathway|
|regulation of leukocyte activation|
|positive regulation of response to external stimulus|
|hematopoietic or lymphoid organ development|
|adaptive immune response|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|activation of immune response|
|regulation of cell activation|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|immune system development|
|tube morphogenesis|
|positive regulation of transferase activity|
|cytokine-mediated signaling pathway|
|import into cell|
|regulation of cell adhesion|
|response to bacterium|
|regulation of cytokine production|
|positive regulation of cell death|
|regulation of ion transport|
|viral process|
|regulated exocytosis|
|regulation of protein transport|
|enzyme linked receptor protein signaling pathway|
|regulation of proteolysis|
|protein localization to organelle|
|regulation of cellular response to stress|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|regulation of defense response|
|innate immune response|
|positive regulation of hydrolase activity|
|regulation of multi-organism process|
|symbiotic process|
|exocytosis|
|regulation of protein kinase activity|
|regulation of secretion|
|interspecies interaction between organisms|
|cation transport|
|tube development|
|positive regulation of immune response|
|circulatory system development|
|regulation of kinase activity|
|peptidyl-amino acid modification|
|anatomical structure formation involved in morphogenesis|
|carboxylic acid metabolic process|
|regulation of cellular localization|
|positive regulation of cell population proliferation|
|leukocyte activation|
|cell adhesion|
|biological adhesion|
|defense response to other organism|
|animal organ morphogenesis|
|regulation of cellular component biogenesis|
|cell migration|
|positive regulation of cell differentiation|
|protein phosphorylation|
|regulation of transferase activity|
|positive regulation of transport|
|intracellular protein transport|
|response to organonitrogen compound|
|oxoacid metabolic process|
|secretion by cell|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|organic acid metabolic process|
|regulation of protein localization|
|export from cell|
|positive regulation of phosphorylation|
|cell activation|
|cell motility|
|localization of cell|
|response to nitrogen compound|
|immune effector process|
|regulation of response to external stimulus|
|response to cytokine|
|secretion|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|regulation of immune response|
|positive regulation of immune system process|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|regulation of hydrolase activity|
|phosphorylation|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|response to biotic stimulus|
|defense response|
|positive regulation of developmental process|
|ion transport|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of response to stress|
|ATP binding|
|protein transport|
|intracellular transport|
|peptide transport|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|regulation of programmed cell death|
|amide transport|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|regulation of cell population proliferation|
|positive regulation of signal transduction|
|regulation of immune system process|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|regulation of protein modification process|
|nitrogen compound transport|
|regulation of transport|
|immune response|
|positive regulation of macromolecule biosynthetic process|
|vesicle-mediated transport|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-2.62|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-2.59|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-2.57|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-2.35|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|-1.87|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|-1.81|
|[[:results:exp392|PT-1 25μM R07 exp392]]|-1.77|
|[[:results:exp481|Ethambutol 25μM R08 exp481]]|-1.71|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|-1.7|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|1.7|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|1.73|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|1.88|
|[[:results:exp211|AICAR 240μM R05 exp211]]|1.96|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|2.14|
|[[:results:exp518|RK-33 8μM R08 exp518]]|2.29|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|2.34|
|[[:results:exp134|MS023 2μM R03 exp134]]|2.35|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|2.55|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|2.61|
|[[:results:exp274|Citral 50μM R06 exp274]]|2.62|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|2.72|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|2.78|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|3.01|
|[[:results:exp116|AICAR 240μM R03 exp116]]|3.1|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|3.26|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|3.31|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|3.33|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|4.06|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rhoh|RHOH]]|0.755|
|[[:human genes:i:igll1|IGLL1]]|0.753|
|[[:human genes:p:pik3cd|PIK3CD]]|0.746|
|[[:human genes:c:cd19|CD19]]|0.741|
|[[:human genes:c:cd81|CD81]]|0.713|
|[[:human genes:c:cd79a|CD79A]]|0.707|
|[[:human genes:m:mapkap1|MAPKAP1]]|0.697|
|[[:human genes:e:ergic1|ERGIC1]]|0.662|
|[[:human genes:c:cd79b|CD79B]]|0.658|
|[[:human genes:r:rictor|RICTOR]]|0.63|
|[[:human genes:a:akt2|AKT2]]|0.583|
|[[:human genes:p:pdpk1|PDPK1]]|0.524|
|[[:human genes:m:mlst8|MLST8]]|0.517|
|[[:human genes:g:ganab|GANAB]]|0.501|
|[[:human genes:v:vezf1|VEZF1]]|0.497|
|[[:human genes:s:ssr3|SSR3]]|0.416|
|[[:human genes:s:ssr2|SSR2]]|0.415|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|1/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1815
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.52 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SYK Expression in NALM6 Cells: 8.52'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>