SYNCRIP [The Human Chemical-Genetic Interaction Map Project]

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======= SYNCRIP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SYNCRIP
  * **<color #00a2e8>Official Name</color>**: synaptotagmin binding cytoplasmic RNA interacting protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10492|10492]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O60506|O60506]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SYNCRIP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SYNCRIP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616686|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the cellular heterogeneous nuclear ribonucleoprotein (hnRNP) family. hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA (hnRNA) and regulate alternative splicing, polyadenylation, and other aspects of mRNA metabolism and transport. The encoded protein plays a role in multiple aspects of mRNA maturation and is associated with several multiprotein complexes including the apoB RNA editing-complex and survival of motor neurons (SMN) complex. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 20. [provided by RefSeq, Dec 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RRM 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|GAIT complex|
|CRD-mediated mRNA stabilization|
|histone pre-mRNA 3end processing complex|
|CRD-mediated mRNA stability complex|
|poly(A) binding|
|mRNA 5-UTR binding|
|mRNA stabilization|
|RNA stabilization|
|negative regulation of mRNA catabolic process|
|negative regulation of RNA catabolic process|
|negative regulation of mRNA metabolic process|
|catalytic step 2 spliceosome|
|osteoblast differentiation|
|negative regulation of translation|
|negative regulation of cellular amide metabolic process|
|ribonucleoprotein complex|
|mRNA binding|
|cellular response to interferon-gamma|
|regulation of mRNA stability|
|response to interferon-gamma|
|regulation of RNA stability|
|regulation of mRNA catabolic process|
|negative regulation of cellular catabolic process|
|ossification|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|RNA splicing, via transesterification reactions|
|negative regulation of catabolic process|
|regulation of mRNA metabolic process|
|regulation of translation|
|RNA splicing|
|regulation of cellular amide metabolic process|
|mRNA processing|
|posttranscriptional regulation of gene expression|
|mRNA metabolic process|
|viral process|
|innate immune response|
|symbiotic process|
|interspecies interaction between organisms|
|regulation of cellular catabolic process|
|RNA processing|
|defense response to other organism|
|regulation of catabolic process|
|cellular response to cytokine stimulus|
|endoplasmic reticulum|
|negative regulation of cellular protein metabolic process|
|response to cytokine|
|negative regulation of protein metabolic process|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|negative regulation of RNA metabolic process|
|defense response|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|RNA metabolic process|
|negative regulation of gene expression|
|immune response|
|positive regulation of gene expression|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|-2.74|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|-2.26|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|-2.22|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|-2.14|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|-2.06|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|-2.01|
|[[:results:exp326|CCT251545 20μM R07 exp326]]|-1.9|
|[[:results:exp375|Lenalidomide 20μM R07 exp375]]|-1.88|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|-1.84|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-1.83|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|-1.82|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|-1.81|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|-1.78|
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|-1.77|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|1.75|
|[[:results:exp116|AICAR 240μM R03 exp116]]|1.96|
|[[:results:exp113|1-Methyl-nicotinamide-chloride 1000μM R03 exp113]]|1.98|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|2.07|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|2.13|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|2.16|
|[[:results:exp135|MS023 7μM R03 exp135]]|2.27|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|2.43|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|2.53|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|3.36|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 6/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|3/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3220
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.11 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SYNCRIP Expression in NALM6 Cells: 9.11'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>