SYNE2 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= SYNE2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SYNE2
  * **<color #00a2e8>Official Name</color>**: spectrin repeat containing nuclear envelope protein 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23224|23224]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8WXH0|Q8WXH0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SYNE2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SYNE2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608442|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a nuclear outer membrane protein that binds cytoplasmic F-actin. This binding tethers the nucleus to the cytoskeleton and aids in the maintenance of the structural integrity of the nucleus. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|KASH|
|Spectrin|
|CH|
|CAMSAP CH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nuclear migration along microfilament|
|nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration|
|nuclear lumen|
|modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration|
|nuclear migration along microtubule|
|cell motility involved in cerebral cortex radial glia guided migration|
|actin filament-based transport|
|cytoskeletal anchoring at nuclear membrane|
|meiotic nuclear membrane microtubule tethering complex|
|centriole-centriole cohesion|
|filopodium membrane|
|telencephalon glial cell migration|
|cerebral cortex radial glia guided migration|
|lamellipodium membrane|
|nuclear migration|
|nuclear outer membrane|
|nucleus localization|
|cerebral cortex radially oriented cell migration|
|centrosome localization|
|microtubule organizing center localization|
|sarcoplasmic reticulum membrane|
|glial cell migration|
|aggresome|
|cerebral cortex cell migration|
|sarcoplasmic reticulum|
|intermediate filament cytoskeleton|
|telencephalon cell migration|
|forebrain cell migration|
|maintenance of protein location in cell|
|organelle transport along microtubule|
|regulation of cilium assembly|
|centrosome cycle|
|microtubule organizing center organization|
|maintenance of location in cell|
|maintenance of protein location|
|actin filament-based movement|
|cerebral cortex development|
|Z disc|
|transport along microtubule|
|maintenance of location|
|pallium development|
|cytoskeleton-dependent intracellular transport|
|nuclear envelope|
|microtubule-based transport|
|regulation of plasma membrane bounded cell projection assembly|
|regulation of cell projection assembly|
|actin filament binding|
|gliogenesis|
|regulation of organelle assembly|
|nuclear membrane|
|telencephalon development|
|actin binding|
|microtubule-based movement|
|establishment of organelle localization|
|forebrain development|
|focal adhesion|
|microtubule cytoskeleton organization|
|centrosome|
|positive regulation of cell migration|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|positive regulation of locomotion|
|actin filament-based process|
|organelle localization|
|microtubule-based process|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|brain development|
|head development|
|regulation of cell migration|
|regulation of cell motility|
|regulation of cellular component biogenesis|
|cell migration|
|central nervous system development|
|regulation of locomotion|
|regulation of cellular component movement|
|cell cycle process|
|localization of cell|
|cell motility|
|cytoskeleton organization|
|mitochondrion|
|regulation of organelle organization|
|locomotion|
|cell cycle|
|intracellular transport|
|movement of cell or subcellular component|
|cellular protein localization|
|cellular macromolecule localization|
|neurogenesis|
|establishment of localization in cell|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp289|Hydroxyurea 15μM R06 exp289]]|1.74|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|1.74|
|[[:results:exp446|4-Nitroquinoline-1-oxide 0.5μM R08 exp446]]|1.84|
|[[:results:exp372|Ibrutinib 1μM R07 exp372]]|1.92|
|[[:results:exp481|Ethambutol 25μM R08 exp481]]|2|
|[[:results:exp291|LLY-284 2.6μM R06 exp291]]|2.12|
|[[:results:exp430|Rifampicin 30μM R08 exp430]]|2.26|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12859
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SYNE2 Expression in NALM6 Cells: 8.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>