SYNJ1 [The Human Chemical-Genetic Interaction Map Project]

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======= SYNJ1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SYNJ1
  * **<color #00a2e8>Official Name</color>**: synaptojanin 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8867|8867]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43426|O43426]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SYNJ1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SYNJ1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604297|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a phosphoinositide phosphatase that regulates levels of membrane phosphatidylinositol-4,5-bisphosphate. As such, expression of this enzyme may affect synaptic transmission and membrane trafficking. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Phosphatase that acts on various phosphoinositides, including phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate (PubMed:27435091). Has a role in clathrin-mediated endocytosis (By similarity). Hydrolyzes PIP2 bound to actin regulatory proteins resulting in the rearrangement of actin filaments downstream of tyrosine kinase and ASH/GRB2 (By similarity). {ECO:0000250|UniProtKB:O18964, ECO:0000250|UniProtKB:Q62910, ECO:0000269|PubMed:27435091}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Syja N|
|Exo endo phos|
|DUF1866|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of endosome organization|
|phosphatidylinositol phosphate 5-phosphatase activity|
|phosphatidylinositol-4-phosphate phosphatase activity|
|regulation of endosome organization|
|synaptic vesicle uncoating|
|clathrin coat disassembly|
|clathrin coat of coated pit|
|vesicle uncoating|
|membrane coat|
|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|
|phosphatidylinositol-3-phosphatase activity|
|inositol phosphate dephosphorylation|
|synaptic vesicle priming|
|phosphorylated carbohydrate dephosphorylation|
|inositol phosphate catabolic process|
|phosphatidylinositol dephosphorylation|
|polyol catabolic process|
|synaptic membrane|
|vesicle membrane|
|phospholipid dephosphorylation|
|synaptic vesicle transport|
|protein depolymerization|
|synaptic vesicle localization|
|synaptic vesicle endocytosis|
|presynaptic endocytosis|
|terminal bouton|
|synaptic vesicle recycling|
|alcohol catabolic process|
|inositol phosphate metabolic process|
|synaptic vesicle exocytosis|
|exocytic process|
|organic hydroxy compound catabolic process|
|presynapse|
|neurotransmitter secretion|
|signal release from synapse|
|phosphatidylinositol biosynthetic process|
|polyol metabolic process|
|synaptic vesicle cycle|
|organophosphate catabolic process|
|vesicle-mediated transport in synapse|
|SH3 domain binding|
|cellular protein complex disassembly|
|learning|
|phosphatidylinositol metabolic process|
|signal release|
|cellular carbohydrate metabolic process|
|establishment of vesicle localization|
|neurotransmitter transport|
|vesicle localization|
|lipid modification|
|glycerophospholipid biosynthetic process|
|glycerolipid biosynthetic process|
|protein-containing complex disassembly|
|phospholipid biosynthetic process|
|learning or memory|
|cognition|
|glycerophospholipid metabolic process|
|dephosphorylation|
|microtubule|
|alcohol metabolic process|
|regulation of neurotransmitter levels|
|establishment of organelle localization|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|cellular component disassembly|
|chemical synaptic transmission|
|anterograde trans-synaptic signaling|
|small molecule catabolic process|
|trans-synaptic signaling|
|organic hydroxy compound metabolic process|
|synaptic signaling|
|carbohydrate metabolic process|
|organophosphate biosynthetic process|
|endocytosis|
|behavior|
|lipid biosynthetic process|
|organelle localization|
|positive regulation of organelle organization|
|import into cell|
|perinuclear region of cytoplasm|
|regulated exocytosis|
|brain development|
|head development|
|exocytosis|
|cellular protein-containing complex assembly|
|membrane organization|
|organophosphate metabolic process|
|cellular lipid metabolic process|
|central nervous system development|
|secretion by cell|
|export from cell|
|cell-cell signaling|
|secretion|
|positive regulation of cellular component organization|
|lipid metabolic process|
|regulation of organelle organization|
|nervous system process|
|RNA binding|
|protein-containing complex assembly|
|small molecule metabolic process|
|organic substance catabolic process|
|establishment of localization in cell|
|protein-containing complex subunit organization|
|vesicle-mediated transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|-1.8|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|1.8|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9993
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.87 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SYNJ1 Expression in NALM6 Cells: 4.87'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>