SYNPO [The Human Chemical-Genetic Interaction Map Project]

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======= SYNPO =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SYNPO
  * **<color #00a2e8>Official Name</color>**: synaptopodin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=11346|11346]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8N3V7|Q8N3V7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SYNPO&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SYNPO|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608155|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity (By similarity). {ECO:0000250}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|spine apparatus assembly|
|positive regulation of postsynaptic cytosolic calcium concentration|
|modification of dendritic spine|
|spine apparatus|
|modification of postsynaptic structure|
|regulation of postsynaptic cytosolic calcium ion concentration|
|modification of synaptic structure|
|postsynaptic modulation of chemical synaptic transmission|
|regulation of long-term neuronal synaptic plasticity|
|visual learning|
|visual behavior|
|regulation of neuronal synaptic plasticity|
|positive regulation of actin filament bundle assembly|
|stress fiber|
|associative learning|
|Schaffer collateral - CA1 synapse|
|regulation of actin filament bundle assembly|
|bicellular tight junction|
|Z disc|
|perikaryon|
|learning|
|dendritic spine|
|regulation of synaptic plasticity|
|positive regulation of supramolecular fiber organization|
|postsynaptic membrane|
|actin cytoskeleton|
|positive regulation of cytoskeleton organization|
|postsynaptic density|
|learning or memory|
|regulation of actin filament organization|
|actin binding|
|synapse organization|
|positive regulation of cytosolic calcium ion concentration|
|cognition|
|response to light stimulus|
|regulation of cytosolic calcium ion concentration|
|regulation of actin cytoskeleton organization|
|glutamatergic synapse|
|regulation of supramolecular fiber organization|
|regulation of actin filament-based process|
|cellular calcium ion homeostasis|
|response to radiation|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|divalent inorganic cation homeostasis|
|positive regulation of cellular component biogenesis|
|regulation of cytoskeleton organization|
|cellular metal ion homeostasis|
|behavior|
|positive regulation of organelle organization|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|organelle assembly|
|ion homeostasis|
|cellular homeostasis|
|regulation of cellular component biogenesis|
|chemical homeostasis|
|response to abiotic stimulus|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|nervous system process|
|homeostatic process|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|2.16|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4754
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.99 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SYNPO Expression in NALM6 Cells: 0.99'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>