SYT12 [The Human Chemical-Genetic Interaction Map Project]

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======= SYT12 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SYT12
  * **<color #00a2e8>Official Name</color>**: synaptotagmin 12
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=91683|91683]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8IV01|Q8IV01]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SYT12&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SYT12|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606436|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|C2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|spontaneous exocytosis of neurotransmitter|
|exocytic vesicle|
|hippocampal mossy fiber to CA3 synapse|
|clathrin binding|
|regulation of dopamine secretion|
|calcium-ion regulated exocytosis|
|regulation of calcium ion-dependent exocytosis|
|long-term synaptic potentiation|
|calcium-dependent phospholipid binding|
|phosphatidylserine binding|
|regulation of catecholamine secretion|
|synaptic vesicle exocytosis|
|SNARE binding|
|synaptic vesicle membrane|
|cellular response to calcium ion|
|regulation of amine transport|
|regulation of response to drug|
|signal release from synapse|
|neurotransmitter secretion|
|regulation of neurotransmitter secretion|
|synaptic vesicle cycle|
|vesicle-mediated transport in synapse|
|regulation of neurotransmitter transport|
|response to calcium ion|
|positive regulation of synaptic transmission|
|regulation of regulated secretory pathway|
|signal release|
|neurotransmitter transport|
|regulation of synaptic plasticity|
|cellular response to metal ion|
|cellular response to inorganic substance|
|regulation of exocytosis|
|regulation of neurotransmitter levels|
|response to metal ion|
|chemical synaptic transmission|
|anterograde trans-synaptic signaling|
|trans-synaptic signaling|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|synaptic signaling|
|response to inorganic substance|
|cell junction|
|regulation of vesicle-mediated transport|
|regulation of ion transport|
|regulated exocytosis|
|calcium ion binding|
|regulation of secretion by cell|
|exocytosis|
|regulation of secretion|
|regulation of cellular localization|
|secretion by cell|
|export from cell|
|cell-cell signaling|
|secretion|
|positive regulation of cell communication|
|positive regulation of signaling|
|establishment of localization in cell|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp336|Asunaprenir 3μM R07 exp336]]|1.79|
|[[:results:exp73|LJH685 5μM R02 exp73]]|2.65|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4839
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.31 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SYT12 Expression in NALM6 Cells: 3.31'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>