SZT2 [The Human Chemical-Genetic Interaction Map Project]

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======= SZT2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SZT2
  * **<color #00a2e8>Official Name</color>**: SZT2 subunit of KICSTOR complex
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23334|23334]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5T011|Q5T011]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SZT2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SZT2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615463|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is expressed in the brain, predominantly in the parietal and frontal cortex as well as in dorsal root ganglia. It is localized to the peroxisome, and is implicated in resistance to oxidative stress. It likely functions by increasing superoxide dismutase (SOD) activity, but itself has no direct SOD activity. Studies in mice show that this gene confers low seizure threshold, and may also enhance epileptogenesis. [provided by RefSeq, Jun 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose (PubMed:28199306, PubMed:28199315). May play a role in the cellular response to oxidative stress (By similarity). {ECO:0000250|UniProtKB:A2A9C3, ECO:0000269|PubMed:28199306, ECO:0000269|PubMed:28199315}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of superoxide dismutase activity|
|KICSTOR complex|
|corpus callosum morphogenesis|
|GATOR1 complex|
|regulation of removal of superoxide radicals|
|GATOR2 complex|
|corpus callosum development|
|negative regulation of TORC1 signaling|
|central nervous system projection neuron axonogenesis|
|regulation of superoxide metabolic process|
|regulation of response to reactive oxygen species|
|central nervous system neuron axonogenesis|
|protein localization to lysosome|
|regulation of TORC1 signaling|
|cellular response to glucose starvation|
|cellular response to amino acid starvation|
|response to amino acid starvation|
|negative regulation of TOR signaling|
|protein localization to vacuole|
|regulation of cellular response to oxidative stress|
|central nervous system neuron development|
|regulation of response to oxidative stress|
|post-embryonic development|
|pigmentation|
|regulation of oxidoreductase activity|
|regulation of TOR signaling|
|peroxisome|
|cellular response to starvation|
|central nervous system neuron differentiation|
|regulation of reactive oxygen species metabolic process|
|response to starvation|
|cellular response to nutrient levels|
|telencephalon development|
|cellular response to extracellular stimulus|
|lysosomal membrane|
|cellular response to external stimulus|
|axonogenesis|
|forebrain development|
|axon development|
|cell morphogenesis involved in neuron differentiation|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|response to nutrient levels|
|negative regulation of intracellular signal transduction|
|cell part morphogenesis|
|response to extracellular stimulus|
|cell morphogenesis involved in differentiation|
|neuron projection development|
|cell morphogenesis|
|protein localization to organelle|
|regulation of cellular response to stress|
|brain development|
|molecular function|
|head development|
|neuron development|
|cellular component morphogenesis|
|central nervous system development|
|neuron differentiation|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of response to stress|
|generation of neurons|
|cellular protein localization|
|cellular macromolecule localization|
|negative regulation of response to stimulus|
|neurogenesis|
|cell development|
|cellular response to stress|
|regulation of intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-4.31|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-4.05|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-3.6|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|-3.53|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-3.39|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-3.39|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|-3.23|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|-2.99|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|-2.72|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-2.65|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|-2.64|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|-2.6|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-2.59|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|-2.58|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|-2.55|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-2.5|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|-2.38|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-2.38|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|-2.37|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-2.36|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|-2.32|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|-2.26|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|-2.25|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|-2.19|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|-2.19|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|-2.15|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|-2.11|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|-2.09|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|-2.08|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|-2.08|
|[[:results:exp17|DABN 20μM R00 exp17]]|-2.05|
|[[:results:exp237|NN-Diethyl-meta-toluamide 100μM R05 exp237]]|-2.04|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-2.02|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|-2.01|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|-2|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-2|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-1.96|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|-1.94|
|[[:results:exp360|Genistein 15μM R07 exp360]]|-1.93|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-1.92|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-1.92|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-1.89|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-1.86|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|-1.84|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|-1.83|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|-1.82|
|[[:results:exp170|Metformin 100 to 150μM on day4 R04 exp170]]|-1.82|
|[[:results:exp239|PFI-2 4μM R05 exp239]]|-1.82|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|-1.78|
|[[:results:exp211|AICAR 240μM R05 exp211]]|-1.77|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|-1.71|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|-1.71|
|[[:results:exp534|Trientine 500μM R08 exp534]]|1.7|
|[[:results:exp506|Momordin-Ic 10μM R08 exp506]]|1.71|
|[[:results:exp151|SGC0946 7μM R03 exp151]]|1.71|
|[[:results:exp303|39°C R06 exp303]]|1.73|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|1.74|
|[[:results:exp453|B02 10μM R08 exp453]]|1.75|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|1.8|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|1.82|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|1.85|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|1.9|
|[[:results:exp423|Zebularine 20μM R07 exp423]]|1.9|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|2.09|
|[[:results:exp155|UNC1999 2μM R03 exp155]]|2.25|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|2.58|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|3.36|
|[[:results:exp504|MK2206 4μM R08 exp504]]|4.14|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:nprl3|NPRL3]]|0.826|
|[[:human genes:n:nprl2|NPRL2]]|0.796|
|[[:human genes:d:depdc5|DEPDC5]]|0.784|
|[[:human genes:k:kptn|KPTN]]|0.774|
|[[:human genes:c:c12orf66|C12orf66]]|0.746|
|[[:human genes:i:itfg2|ITFG2]]|0.743|
|[[:human genes:s:sesn2|SESN2]]|0.653|
|[[:human genes:t:tsc2|TSC2]]|0.562|
|[[:human genes:t:tsc1|TSC1]]|0.512|
|[[:human genes:c:ccdc130|CCDC130]]|0.469|
|[[:human genes:z:zfp36l2|ZFP36L2]]|0.433|
|[[:human genes:h:hexim1|HEXIM1]]|0.426|
|[[:human genes:a:anp32a|ANP32A]]|0.414|
|[[:human genes:p:prkaa1|PRKAA1]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14739
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.82 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SZT2 Expression in NALM6 Cells: 6.82'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>