TACC2 [The Human Chemical-Genetic Interaction Map Project]

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======= TACC2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TACC2
  * **<color #00a2e8>Official Name</color>**: transforming acidic coiled-coil containing protein 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10579|10579]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95359|O95359]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TACC2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TACC2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605302|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Transforming acidic coiled-coil proteins are a conserved family of centrosome- and microtubule-interacting proteins that are implicated in cancer. This gene encodes a protein that concentrates at centrosomes throughout the cell cycle. This gene lies within a chromosomal region associated with tumorigenesis. Expression of this gene is induced by erythropoietin and is thought to affect the progression of breast tumors. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TACC|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nuclear hormone receptor binding|
|mitotic spindle organization|
|microtubule cytoskeleton organization involved in mitosis|
|cerebral cortex development|
|spindle organization|
|microtubule organizing center|
|pallium development|
|telencephalon development|
|forebrain development|
|microtubule cytoskeleton organization|
|cell population proliferation|
|mitotic cell cycle process|
|microtubule-based process|
|mitotic cell cycle|
|brain development|
|head development|
|central nervous system development|
|cell cycle process|
|cytoskeleton organization|
|cell cycle|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp399|Salubrinal 20μM R07 exp399]]|1.75|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|2.09|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7456
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.96 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TACC2 Expression in NALM6 Cells: 3.96'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>