TADA3 [The Human Chemical-Genetic Interaction Map Project]

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======= TADA3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TADA3
  * **<color #00a2e8>Official Name</color>**: transcriptional adaptor 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10474|10474]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75528|O75528]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TADA3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TADA3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602945|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex. Also known as a coactivator for p53/TP53-dependent transcriptional activation. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. {ECO:0000269|PubMed:11707411, ECO:0000269|PubMed:19103755}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ada3|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of tubulin deacetylation|
|STAGA complex|
|transcription factor TFTC complex|
|SAGA complex|
|Ada2/Gcn5/Ada3 transcription activator complex|
|nuclear receptor binding|
|intracellular estrogen receptor signaling pathway|
|regulation of histone deacetylation|
|regulation of protein deacetylation|
|histone H3 acetylation|
|histone acetyltransferase activity|
|histone H4 acetylation|
|nuclear receptor transcription coactivator activity|
|intracellular steroid hormone receptor signaling pathway|
|mitotic spindle|
|intracellular|
|histone acetylation|
|internal peptidyl-lysine acetylation|
|steroid hormone mediated signaling pathway|
|peptidyl-lysine acetylation|
|internal protein amino acid acetylation|
|protein acetylation|
|regulation of histone modification|
|intracellular receptor signaling pathway|
|hormone-mediated signaling pathway|
|protein acylation|
|cellular response to steroid hormone stimulus|
|regulation of chromatin organization|
|protein domain specific binding|
|protein deubiquitination|
|transcription coactivator activity|
|regulation of protein stability|
|protein modification by small protein removal|
|peptidyl-lysine modification|
|response to steroid hormone|
|regulation of chromosome organization|
|histone modification|
|covalent chromatin modification|
|cellular response to lipid|
|cellular response to organic cyclic compound|
|cellular response to hormone stimulus|
|mitotic cell cycle|
|chromatin organization|
|response to lipid|
|peptidyl-amino acid modification|
|response to hormone|
|response to organic cyclic compound|
|protein modification by small protein conjugation or removal|
|chromosome organization|
|cellular response to endogenous stimulus|
|proteolysis|
|regulation of organelle organization|
|cell cycle|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|positive regulation of transcription, DNA-templated|
|regulation of phosphorylation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of RNA metabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|-1.74|
|[[:results:exp130|JQ1 0.01μM R03 exp130]]|-1.7|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|2.32|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|2.87|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:taf6l|TAF6L]]|0.592|
|[[:human genes:t:taf5l|TAF5L]]|0.588|
|[[:human genes:s:supt7l|SUPT7L]]|0.575|
|[[:human genes:t:tada2b|TADA2B]]|0.56|
|[[:human genes:c:ccdc101|CCDC101]]|0.532|
|[[:human genes:k:kat2a|KAT2A]]|0.532|
|[[:human genes:m:med13|MED13]]|0.503|
|[[:human genes:t:tada1|TADA1]]|0.496|
|[[:human genes:t:tle4|TLE4]]|0.495|
|[[:human genes:m:med13l|MED13L]]|0.485|
|[[:human genes:b:brpf1|BRPF1]]|0.473|
|[[:human genes:m:mllt1|MLLT1]]|0.444|
|[[:human genes:s:supt20h|SUPT20H]]|0.432|
|[[:human genes:m:max|MAX]]|0.426|
|[[:human genes:h:hdac8|HDAC8]]|0.426|
|[[:human genes:s:smarcd1|SMARCD1]]|0.425|
|[[:human genes:d:dcaf7|DCAF7]]|0.418|
|[[:human genes:u:ube2l3|UBE2L3]]|0.412|
|[[:human genes:e:erg|ERG]]|0.403|
|[[:human genes:i:id3|ID3]]|0.402|
|[[:human genes:g:gltscr1l|GLTSCR1L]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 33/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|2/25|
|breast|4/33|
|central nervous system|0/56|
|cervix|1/4|
|colorectal|1/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|1/21|
|liver|0/20|
|lung|3/75|
|lymphocyte|2/14|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|2/15|
|prostate|1/1|
|skin|1/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|4/22|
|urinary tract|0/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 426
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.06 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TADA3 Expression in NALM6 Cells: 5.06'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>