TAF10 [The Human Chemical-Genetic Interaction Map Project]

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======= TAF10 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TAF10
  * **<color #00a2e8>Official Name</color>**: TATA-box binding protein associated factor 10
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6881|6881]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q12962|Q12962]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TAF10&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TAF10|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600475|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TIIFD is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TFIID 30kDa|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|PCAF complex|
|STAGA complex|
|hepatocyte differentiation|
|RNA polymerase II general transcription initiation factor activity|
|transcription factor TFTC complex|
|RNA polymerase binding|
|histone deubiquitination|
|transcription factor TFIID complex|
|estrogen receptor binding|
|histone H3 acetylation|
|histone acetyltransferase activity|
|multicellular organism growth|
|histone acetylation|
|internal peptidyl-lysine acetylation|
|G1/S transition of mitotic cell cycle|
|cell cycle G1/S phase transition|
|peptidyl-lysine acetylation|
|internal protein amino acid acetylation|
|regulation of DNA binding|
|liver development|
|hepaticobiliary system development|
|protein acetylation|
|transcription initiation from RNA polymerase II promoter|
|regulation of signal transduction by p53 class mediator|
|protein acylation|
|DNA-templated transcription, initiation|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|protein deubiquitination|
|protein modification by small protein removal|
|peptidyl-lysine modification|
|protein homooligomerization|
|enzyme binding|
|histone modification|
|covalent chromatin modification|
|regulation of binding|
|developmental growth|
|growth|
|gland development|
|transcription by RNA polymerase II|
|protein complex oligomerization|
|mitotic cell cycle process|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|epithelial cell differentiation|
|mitotic cell cycle|
|perinuclear region of cytoplasm|
|chromatin organization|
|cellular protein-containing complex assembly|
|peptidyl-amino acid modification|
|apoptotic process|
|protein modification by small protein conjugation or removal|
|cell cycle process|
|programmed cell death|
|chromosome organization|
|cell death|
|nucleobase-containing compound biosynthetic process|
|epithelium development|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|proteolysis|
|organic cyclic compound biosynthetic process|
|cell cycle|
|DNA binding|
|protein-containing complex assembly|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|tissue development|
|macromolecule biosynthetic process|
|regulation of intracellular signal transduction|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|1.71|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|1.78|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|1.91|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|2.1|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|2.17|
|[[:results:exp482|Fas-L 44ng/ml R08 exp482]]|2.19|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 116/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|3/28|
|blood|6/28|
|bone|4/25|
|breast|5/33|
|central nervous system|10/56|
|cervix|1/4|
|colorectal|2/17|
|esophagus|2/13|
|fibroblast|0/1|
|gastric|3/15|
|kidney|2/21|
|liver|2/20|
|lung|13/75|
|lymphocyte|2/14|
|ovary|5/26|
|pancreas|0/24|
|peripheral nervous system|5/16|
|plasma cell|8/15|
|prostate|0/1|
|skin|4/24|
|soft tissue|2/7|
|thyroid|1/2|
|upper aerodigestive|1/22|
|urinary tract|8/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1420
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.49 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TAF10 Expression in NALM6 Cells: 5.49'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>