TAGLN [The Human Chemical-Genetic Interaction Map Project]

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======= TAGLN =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TAGLN
  * **<color #00a2e8>Official Name</color>**: transgelin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6876|6876]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q01995|Q01995]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TAGLN&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TAGLN|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600818|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Actin cross-linking/gelling protein (By similarity). Involved in calcium interactions and contractile properties of the cell that may contribute to replicative senescence. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Calponin|
|CH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|actin filament binding|
|muscle organ development|
|muscle structure development|
|epithelial cell differentiation|
|epithelium development|
|tissue development|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp239|PFI-2 4μM R05 exp239]]|1.88|
|[[:results:exp348|Cyclosporin-A 3μM R07 exp348]]|2.39|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:v:vasn|VASN]]|0.478|
|[[:human genes:d:dtl|DTL]]|0.449|
|[[:human genes:s:sap30bp|SAP30BP]]|0.445|
|[[:human genes:t:tfip11|TFIP11]]|0.443|
|[[:human genes:n:nbpf10|NBPF10]]|0.441|
|[[:human genes:n:nup160|NUP160]]|0.434|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.428|
|[[:human genes:c:cdc73|CDC73]]|0.427|
|[[:human genes:c:copb1|COPB1]]|0.426|
|[[:human genes:p:psmb4|PSMB4]]|0.423|
|[[:human genes:p:pan3|PAN3]]|0.422|
|[[:human genes:r:rbbp5|RBBP5]]|0.416|
|[[:human genes:c:copg1|COPG1]]|0.415|
|[[:human genes:p:psmc3|PSMC3]]|0.413|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.413|
|[[:human genes:p:paf1|PAF1]]|0.412|
|[[:human genes:c:chaf1a|CHAF1A]]|0.411|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.411|
|[[:human genes:z:znf148|ZNF148]]|0.411|
|[[:human genes:s:slc6a17|SLC6A17]]|0.406|
|[[:human genes:c:chmp2a|CHMP2A]]|0.405|
|[[:human genes:r:rrp15|RRP15]]|0.403|
|[[:human genes:c:chd4|CHD4]]|0.402|
|[[:human genes:d:ddt|DDT]]|0.402|
|[[:human genes:s:supt5h|SUPT5H]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2840
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.09 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TAGLN Expression in NALM6 Cells: 3.09'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>