TAOK2 [The Human Chemical-Genetic Interaction Map Project]

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======= TAOK2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TAOK2
  * **<color #00a2e8>Official Name</color>**: TAO kinase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9344|9344]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UL54|Q9UL54]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TAOK2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TAOK2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613199|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a serine/threonine protein kinase that is involved in many different processes, including, cell signaling, microtubule organization and stability, and apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Isoform 1, but not isoform 2, plays a role in apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation. This function, which requires the activation of MAPK8/JNK and nuclear localization of C-terminally truncated isoform 1, may be linked to the mitochondrial CASP9-associated death pathway. Isoform 1 binds to microtubules and affects their organization and stability independently of its kinase activity. Prevents MAP3K7-mediated activation of CHUK, and thus NF-kappa-B activation, but not that of MAPK8/JNK. May play a role in the osmotic stress-MAPK8 pathway. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Following homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14/p38 MAPK which in turn phosphorylates isoform 2. This process leads to PCDH8 endocytosis and CDH2 cointernalization. Both isoforms are involved in MAPK14 phosphorylation. {ECO:0000269|PubMed:10660600, ECO:0000269|PubMed:11279118, ECO:0000269|PubMed:12639963, ECO:0000269|PubMed:12665513, ECO:0000269|PubMed:13679851, ECO:0000269|PubMed:16893890, ECO:0000269|PubMed:17158878, ECO:0000269|PubMed:17396146}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase|
|Pkinase Tyr|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|basal dendrite morphogenesis|
|basal dendrite arborization|
|basal dendrite development|
|dendrite arborization|
|dendritic growth cone|
|neuron projection arborization|
|mitogen-activated protein kinase kinase binding|
|mitotic G2 DNA damage checkpoint|
|MAP kinase kinase kinase activity|
|neuropilin binding|
|tau-protein kinase activity|
|positive regulation of protein autophosphorylation|
|cell-substrate adherens junction assembly|
|focal adhesion assembly|
|axonal growth cone|
|mitotic G2/M transition checkpoint|
|G2 DNA damage checkpoint|
|adherens junction assembly|
|cell-substrate junction assembly|
|tau protein binding|
|regulation of protein autophosphorylation|
|activation of MAPKK activity|
|dendrite morphogenesis|
|adherens junction organization|
|negative regulation of G2/M transition of mitotic cell cycle|
|mitotic DNA damage checkpoint|
|negative regulation of cell cycle G2/M phase transition|
|dendrite development|
|mitotic DNA integrity checkpoint|
|stress-activated MAPK cascade|
|cell-matrix adhesion|
|DNA damage checkpoint|
|positive regulation of JNK cascade|
|stress-activated protein kinase signaling cascade|
|cytoplasmic vesicle membrane|
|DNA integrity checkpoint|
|regulation of cell shape|
|mitotic cell cycle checkpoint|
|activation of MAPK activity|
|protein targeting to membrane|
|positive regulation of stress-activated MAPK cascade|
|positive regulation of stress-activated protein kinase signaling cascade|
|cell junction assembly|
|cell-substrate adhesion|
|regulation of JNK cascade|
|protein autophosphorylation|
|cell cycle checkpoint|
|regulation of G2/M transition of mitotic cell cycle|
|receptor complex|
|regulation of cell cycle G2/M phase transition|
|negative regulation of mitotic cell cycle phase transition|
|cell junction organization|
|actin cytoskeleton|
|negative regulation of cell cycle phase transition|
|regulation of stress-activated MAPK cascade|
|regulation of stress-activated protein kinase signaling cascade|
|cytoplasmic vesicle|
|positive regulation of MAP kinase activity|
|establishment of protein localization to membrane|
|axon|
|negative regulation of mitotic cell cycle|
|neuron projection|
|negative regulation of cell cycle process|
|activation of protein kinase activity|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|regulation of actin cytoskeleton organization|
|protein targeting|
|protein serine/threonine kinase activity|
|axonogenesis|
|MAPK cascade|
|regulation of actin filament-based process|
|signal transduction by protein phosphorylation|
|axon development|
|regulation of mitotic cell cycle phase transition|
|regulation of cell growth|
|cell morphogenesis involved in neuron differentiation|
|regulation of cell cycle phase transition|
|neuron projection morphogenesis|
|protein localization to membrane|
|plasma membrane bounded cell projection morphogenesis|
|regulation of cell morphogenesis|
|cell projection morphogenesis|
|actin cytoskeleton organization|
|cell part morphogenesis|
|regulation of protein serine/threonine kinase activity|
|positive regulation of protein kinase activity|
|regulation of cytoskeleton organization|
|positive regulation of MAPK cascade|
|cell morphogenesis involved in differentiation|
|actin filament-based process|
|negative regulation of cell cycle|
|positive regulation of kinase activity|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|positive regulation of transferase activity|
|neuron projection development|
|regulation of growth|
|mitotic cell cycle|
|cell morphogenesis|
|regulation of cellular response to stress|
|regulation of cell cycle process|
|regulation of MAPK cascade|
|cellular response to DNA damage stimulus|
|regulation of protein kinase activity|
|neuron development|
|cellular component morphogenesis|
|nucleolus|
|regulation of kinase activity|
|apoptotic process|
|cell adhesion|
|biological adhesion|
|cell migration|
|protein phosphorylation|
|regulation of transferase activity|
|intracellular protein transport|
|cell cycle process|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|programmed cell death|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|cell motility|
|localization of cell|
|cell death|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|cell projection organization|
|regulation of cell cycle|
|positive regulation of protein modification process|
|phosphorylation|
|regulation of organelle organization|
|locomotion|
|cell cycle|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of response to stress|
|ATP binding|
|protein transport|
|intracellular transport|
|generation of neurons|
|peptide transport|
|movement of cell or subcellular component|
|amide transport|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|neurogenesis|
|cell development|
|positive regulation of signal transduction|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3563
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.62 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TAOK2 Expression in NALM6 Cells: 6.62'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>