TAP1 [The Human Chemical-Genetic Interaction Map Project]

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======= TAP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TAP1
  * **<color #00a2e8>Official Name</color>**: transporter 1, ATP binding cassette subfamily B member
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6890|6890]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q03518|Q03518]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TAP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TAP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/170260|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in the pumping of degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment where class I molecules assemble. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association. Expression of TAP1 is down-regulated by human Epstein-Barr virus vIL-10 protein, thereby affecting the transport of peptides into the endoplasmic reticulum and subsequent peptide loading by MHC class I molecules.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ABC membrane|
|ABC tran|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|TAP complex|
|ATPase-coupled peptide transmembrane transporter activity|
|cytosol to endoplasmic reticulum transport|
|ATPase-coupled peptide antigen transmembrane transporter activity|
|TAP1 binding|
|TAP2 binding|
|MHC class I peptide loading complex|
|vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane|
|MHC class Ib protein binding|
|peptide transmembrane transporter activity|
|antigen processing and presentation of endogenous peptide antigen|
|antigen processing and presentation of endogenous peptide antigen via MHC class I|
|MHC class I protein binding|
|antigen processing and presentation of endogenous antigen|
|peptide antigen binding|
|ADP binding|
|ATPase-coupled transmembrane transporter activity|
|endoplasmic reticulum-Golgi intermediate compartment membrane|
|vesicle fusion|
|phagocytic vesicle membrane|
|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|
|organelle membrane fusion|
|antigen processing and presentation of exogenous peptide antigen via MHC class I|
|organelle fusion|
|antigen processing and presentation of peptide antigen via MHC class I|
|integral component of endoplasmic reticulum membrane|
|membrane fusion|
|microtubule organizing center|
|antigen processing and presentation of exogenous peptide antigen|
|antigen processing and presentation of exogenous antigen|
|antigen processing and presentation of peptide antigen|
|antigen processing and presentation|
|ATPase activity|
|vesicle organization|
|adaptive immune response|
|viral process|
|symbiotic process|
|interspecies interaction between organisms|
|membrane organization|
|protein homodimerization activity|
|endoplasmic reticulum membrane|
|ion transmembrane transport|
|endoplasmic reticulum|
|transmembrane transport|
|defense response|
|ion transport|
|ATP binding|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|immune response|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|-1.84|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|-1.83|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-1.75|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|1.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8841
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.15 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TAP1 Expression in NALM6 Cells: 7.15'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>