TARS [The Human Chemical-Genetic Interaction Map Project]

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======= TARS =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TARS1
  * **<color #00a2e8>Official Name</color>**: threonyl-tRNA synthetase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6897|6897]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P26639|P26639]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TARS&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TARS|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/187790|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|tRNA SAD|
|HGTP anticodon|
|tRNA-synt 2b|
|TGS|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|threonyl-tRNA aminoacylation|
|threonine-tRNA ligase activity|
|tRNA aminoacylation for protein translation|
|tRNA aminoacylation|
|amino acid activation|
|tRNA binding|
|tRNA metabolic process|
|actin cytoskeleton|
|cellular amino acid metabolic process|
|translation|
|peptide biosynthetic process|
|ncRNA metabolic process|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|protein homodimerization activity|
|carboxylic acid metabolic process|
|oxoacid metabolic process|
|organic acid metabolic process|
|organonitrogen compound biosynthetic process|
|ATP binding|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|-2.37|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|-1.84|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|-1.7|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|1.76|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|1.85|
|[[:results:exp115|A-366 10μM R03 exp115]]|2.03|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|2.04|
|[[:results:exp169|BH1 1μM R04 exp169]]|2.11|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 735/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|16/16|
|ovary|25/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|23/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 153
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.67 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TARS Expression in NALM6 Cells: 7.67'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>