TAX1BP1 [The Human Chemical-Genetic Interaction Map Project]

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======= TAX1BP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TAX1BP1
  * **<color #00a2e8>Official Name</color>**: Tax1 binding protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8887|8887]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q86VP1|Q86VP1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TAX1BP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TAX1BP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605326|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a HTLV-1 tax1 binding protein. The encoded protein interacts with TNFAIP3, and inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degradation of this protein by caspase-3-like family proteins is associated with apoptosis induced by TNF. This protein may also have a role in the inhibition of inflammatory signaling pathways. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CALCOCO1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of type I interferon production|
|regulation of tumor necrosis factor-mediated signaling pathway|
|negative regulation of NF-kappaB transcription factor activity|
|kinase binding|
|regulation of type I interferon production|
|negative regulation of DNA-binding transcription factor activity|
|regulation of cytokine-mediated signaling pathway|
|regulation of response to cytokine stimulus|
|negative regulation of cytokine production|
|regulation of DNA-binding transcription factor activity|
|regulation of cytokine production|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|apoptotic process|
|negative regulation of cell death|
|programmed cell death|
|cell death|
|negative regulation of molecular function|
|negative regulation of multicellular organismal process|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of cell death|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp77|Prochlorperazine 5.2μM R02 exp77]]|-1.98|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|-1.81|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|-1.7|
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|1.71|
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|1.84|
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|1.95|
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|1.96|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|2.13|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|2.23|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|2.41|
|[[:results:exp516|Pyrazinamide 100μM R08 exp516]]|2.42|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.436|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18727
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.8 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TAX1BP1 Expression in NALM6 Cells: 5.8'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>