TBC1D23 [The Human Chemical-Genetic Interaction Map Project]

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======= TBC1D23 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TBC1D23
  * **<color #00a2e8>Official Name</color>**: TBC1 domain family member 23
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55773|55773]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NUY8|Q9NUY8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TBC1D23&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TBC1D23|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617687|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Putative Rab GTPase-activating protein which plays a role in vesicular trafficking (PubMed:28823707). Involved in endosome-to-Golgi trafficking. Acts as a bridging protein by binding simultaneously to golgins, including GOLGA1 and GOLGA4, located at the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles (PubMed:29084197). Plays a role in brain development, including in cortical neuron positioning (By similarity). May also be important for neurite outgrowth, possibly through its involvement in membrane trafficking and cargo delivery, 2 processes that are essential for axonal and dendritic growth (By similarity). May act as a general inhibitor of innate immunity signaling, strongly inhibiting multiple TLR and dectin/CLEC7A-signaling pathways. Does not alter initial activation events, but instead affects maintenance of inflammatory gene expression several hours after bacterial lipopolysaccharide (LPS) challenge (By similarity). {ECO:0000250|UniProtKB:Q8K0F1, ECO:0000269|PubMed:28823707}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TBC|
|Rhodanese|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|vesicle tethering to Golgi|
|vesicle tethering|
|embryonic brain development|
|WASH complex|
|vesicle targeting|
|retrograde transport, endosome to Golgi|
|positive regulation of interleukin-6 production|
|regulation of interleukin-6 production|
|cytosolic transport|
|regulation of tumor necrosis factor production|
|regulation of tumor necrosis factor superfamily cytokine production|
|trans-Golgi network|
|establishment of vesicle localization|
|vesicle localization|
|endosomal transport|
|cytoplasmic vesicle|
|regulation of inflammatory response|
|establishment of organelle localization|
|embryonic organ development|
|positive regulation of cytokine production|
|organelle localization|
|neuron projection development|
|regulation of cytokine production|
|brain development|
|regulation of defense response|
|head development|
|neuron development|
|embryo development|
|central nervous system development|
|Golgi apparatus|
|neuron differentiation|
|regulation of response to external stimulus|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|regulation of response to stress|
|intracellular transport|
|generation of neurons|
|neurogenesis|
|cell development|
|positive regulation of multicellular organismal process|
|establishment of localization in cell|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-4.55|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-4.25|
|[[:results:exp169|BH1 1μM R04 exp169]]|-3.05|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-3|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|-2.45|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-2.27|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|-1.95|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|1.96|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:gpr107|GPR107]]|0.518|
|[[:human genes:r:rab1b|RAB1B]]|0.475|
|[[:human genes:a:apba3|APBA3]]|0.475|
|[[:human genes:m:mtmr6|MTMR6]]|0.449|
|[[:human genes:u:unc50|UNC50]]|0.445|
|[[:human genes:s:scap|SCAP]]|0.445|
|[[:human genes:s:slc39a9|SLC39A9]]|0.445|
|[[:human genes:j:jtb|JTB]]|0.435|
|[[:human genes:v:vkorc1l1|VKORC1L1]]|0.429|
|[[:human genes:s:sgms1|SGMS1]]|0.429|
|[[:human genes:c:cog7|COG7]]|0.427|
|[[:human genes:c:cog6|COG6]]|0.427|
|[[:human genes:r:ralgapb|RALGAPB]]|0.425|
|[[:human genes:w:wdr11|WDR11]]|0.411|
|[[:human genes:f:fam160b1|FAM160B1]]|0.407|
|[[:human genes:t:tbc1d22b|TBC1D22B]]|0.406|
|[[:human genes:f:f8a3|F8A3]]|0.402|
|[[:human genes:r:rgp1|RGP1]]|0.402|
|[[:human genes:z:zfat|ZFAT]]|0.401|
|[[:human genes:f:f8a2|F8A2]]|0.401|
|[[:human genes:f:f8a1|F8A1]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9486
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TBC1D23 Expression in NALM6 Cells: 5.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>