TBC1D32 [The Human Chemical-Genetic Interaction Map Project]

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======= TBC1D32 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TBC1D32
  * **<color #00a2e8>Official Name</color>**: TBC1 domain family member 32
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=221322|221322]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96NH3|Q96NH3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TBC1D32&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TBC1D32|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615867|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a TBC-domain containing protein. Studies of a similar protein in mouse and zebrafish suggest that the encoded protein is involved in sonic hedgehog signaling, and that it interacts with and stabilizes cell cycle-related kinase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Required for high-level Shh responses in the developing neural tube. Together with CDK20, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to Shh signaling (By similarity). {ECO:0000250}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|retinal pigment epithelium development|
|smoothened signaling pathway involved in dorsal/ventral neural tube patterning|
|dorsal/ventral neural tube patterning|
|neural tube patterning|
|non-motile cilium assembly|
|protein localization to cilium|
|embryonic digit morphogenesis|
|smoothened signaling pathway|
|lens development in camera-type eye|
|dorsal/ventral pattern formation|
|determination of left/right symmetry|
|determination of bilateral symmetry|
|specification of symmetry|
|embryonic appendage morphogenesis|
|embryonic limb morphogenesis|
|retina development in camera-type eye|
|appendage morphogenesis|
|limb morphogenesis|
|neural tube development|
|appendage development|
|limb development|
|cilium|
|camera-type eye development|
|regionalization|
|cilium assembly|
|eye development|
|visual system development|
|sensory system development|
|cilium organization|
|pattern specification process|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|heart development|
|sensory organ development|
|embryonic morphogenesis|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|protein localization to organelle|
|organelle assembly|
|tube development|
|circulatory system development|
|embryo development|
|epithelium development|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|cellular protein localization|
|cellular macromolecule localization|
|tissue development|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp538|ZLN024 50μM R08 exp538]]|1.94|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9147
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.55 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TBC1D32 Expression in NALM6 Cells: 4.55'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>