TBC1D5 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= TBC1D5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TBC1D5
  * **<color #00a2e8>Official Name</color>**: TBC1 domain family member 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9779|9779]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q92609|Q92609]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TBC1D5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TBC1D5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615740|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May act as a GTPase-activating protein (GAP) for Rab family protein(s). May act as a GAP for RAB7A. Can displace RAB7A and retromer CSC subcomplex from the endosomal membrane to the cytosol; at least retromer displacement seems to require its catalytic activity (PubMed:19531583, PubMed:20923837). Required for retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN); the function seems to require its catalytic activity. Involved in regulation of autophagy (PubMed:22354992). May act as a molecular switch between endosomal and autophagosomal transport and is involved in reprogramming vesicle trafficking upon autophagy induction. Involved in the trafficking of ATG9A upon activation of autophagy. May regulate the recruitment of ATG9A-AP2-containing vesicles to autophagic membranes (PubMed:24603492). {ECO:0000269|PubMed:19531583, ECO:0000269|PubMed:20923837, ECO:0000269|PubMed:22354992, ECO:0000269|PubMed:24603492, ECO:0000305|PubMed:19531583, ECO:0000305|PubMed:22354992, ECO:0000305|PubMed:24603492}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TBC|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|retromer complex binding|
|Atg1/ULK1 kinase complex|
|AP-2 adaptor complex binding|
|AP-2 adaptor complex|
|retromer complex|
|positive regulation of receptor internalization|
|positive regulation of receptor-mediated endocytosis|
|regulation of receptor internalization|
|autophagosome|
|regulation of cilium assembly|
|retrograde transport, endosome to Golgi|
|activation of GTPase activity|
|positive regulation of endocytosis|
|regulation of receptor-mediated endocytosis|
|cytosolic transport|
|Rab GTPase binding|
|macroautophagy|
|response to starvation|
|regulation of plasma membrane bounded cell projection assembly|
|regulation of cell projection assembly|
|regulation of endocytosis|
|endosome membrane|
|regulation of organelle assembly|
|endosomal transport|
|autophagy|
|process utilizing autophagic mechanism|
|GTPase activator activity|
|positive regulation of GTPase activity|
|regulation of GTPase activity|
|response to nutrient levels|
|response to extracellular stimulus|
|regulation of vesicle-mediated transport|
|intracellular membrane-bounded organelle|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|positive regulation of hydrolase activity|
|regulation of cellular component biogenesis|
|Golgi apparatus|
|positive regulation of transport|
|intracellular protein transport|
|positive regulation of cellular component organization|
|regulation of hydrolase activity|
|regulation of organelle organization|
|positive regulation of catalytic activity|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|positive regulation of molecular function|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|1.72|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|1.77|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|2.01|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|2.24|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:f:fnip1|FNIP1]]|0.507|
|[[:human genes:l:lamtor2|LAMTOR2]]|0.495|
|[[:human genes:w:wdr24|WDR24]]|0.493|
|[[:human genes:l:lamtor4|LAMTOR4]]|0.484|
|[[:human genes:m:mios|MIOS]]|0.479|
|[[:human genes:w:wdr59|WDR59]]|0.452|
|[[:human genes:v:vps41|VPS41]]|0.44|
|[[:human genes:f:flcn|FLCN]]|0.439|
|[[:human genes:l:lamtor3|LAMTOR3]]|0.434|
|[[:human genes:l:lamtor5|LAMTOR5]]|0.434|
|[[:human genes:f:fbxo11|FBXO11]]|0.433|
|[[:human genes:r:rfwd2|RFWD2]]|0.422|
|[[:human genes:r:rraga|RRAGA]]|0.416|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6003
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.52 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TBC1D5 Expression in NALM6 Cells: 6.52'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>