TCAF1 [The Human Chemical-Genetic Interaction Map Project]

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======= TCAF1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TCAF1
  * **<color #00a2e8>Official Name</color>**: TRPM8 channel associated factor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9747|9747]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y4C2|Q9Y4C2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TCAF1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TCAF1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616251|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Positively regulates the plasma membrane cation channel TRPM8 activity. Involved in the recruitment of TRPM8 to the cell surface. Promotes prostate cancer cell migration inhibition in a TRPM8-dependent manner. {ECO:0000269|PubMed:25559186}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of anion channel activity|
|positive regulation of anion transmembrane transport|
|regulation of anion channel activity|
|regulation of anion transmembrane transport|
|positive regulation of protein targeting to membrane|
|regulation of protein targeting to membrane|
|positive regulation of anion transport|
|regulation of protein targeting|
|regulation of anion transport|
|positive regulation of ion transmembrane transporter activity|
|positive regulation of transporter activity|
|positive regulation of protein localization to membrane|
|ion channel binding|
|positive regulation of intracellular protein transport|
|positive regulation of ion transmembrane transport|
|regulation of protein localization to membrane|
|positive regulation of transmembrane transport|
|positive regulation of intracellular transport|
|regulation of intracellular protein transport|
|regulation of ion transmembrane transporter activity|
|negative regulation of cell migration|
|regulation of transmembrane transporter activity|
|negative regulation of cell motility|
|positive regulation of ion transport|
|regulation of transporter activity|
|negative regulation of cellular component movement|
|negative regulation of locomotion|
|positive regulation of cellular protein localization|
|regulation of intracellular transport|
|positive regulation of protein transport|
|positive regulation of establishment of protein localization|
|regulation of ion transmembrane transport|
|regulation of cellular protein localization|
|regulation of transmembrane transport|
|regulation of ion transport|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of cell migration|
|regulation of cell motility|
|regulation of cellular localization|
|regulation of locomotion|
|positive regulation of transport|
|regulation of cellular component movement|
|regulation of protein localization|
|positive regulation of molecular function|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|1.77|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|2.36|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18531
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.92 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TCAF1 Expression in NALM6 Cells: 5.92'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>