TCEA1 [The Human Chemical-Genetic Interaction Map Project]

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======= TCEA1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TCEA1
  * **<color #00a2e8>Official Name</color>**: transcription elongation factor A1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6917|6917]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P23193|P23193]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TCEA1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TCEA1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601425|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Med26|
|TFIIS M|
|TFIIS C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of exoribonuclease activity|
|positive regulation of exonuclease activity|
|positive regulation of exoribonuclease activity|
|regulation of exonuclease activity|
|positive regulation of nuclease activity|
|regulation of ribonuclease activity|
|regulation of nuclease activity|
|transcription factor TFIID complex|
|transcription-coupled nucleotide-excision repair|
|transcription elongation from RNA polymerase II promoter|
|DNA-templated transcription, elongation|
|nucleotide-excision repair|
|transcription by RNA polymerase II|
|DNA repair|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|DNA metabolic process|
|positive regulation of hydrolase activity|
|cellular response to DNA damage stimulus|
|zinc ion binding|
|nucleolus|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|positive regulation of transcription by RNA polymerase II|
|regulation of hydrolase activity|
|organic cyclic compound biosynthetic process|
|positive regulation of catalytic activity|
|DNA binding|
|positive regulation of transcription, DNA-templated|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp224|CB-839 10μM R05 exp224]]|-2.48|
|[[:results:exp274|Citral 50μM R06 exp274]]|-2.02|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|-1.98|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|-1.97|
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|-1.84|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|-1.82|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|-1.82|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|-1.8|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|-1.77|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|2.03|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4068
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.67 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TCEA1 Expression in NALM6 Cells: 6.67'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>