TERF1 [The Human Chemical-Genetic Interaction Map Project]

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======= TERF1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TERF1
  * **<color #00a2e8>Official Name</color>**: telomeric repeat binding factor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7013|7013]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P54274|P54274]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TERF1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TERF1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600951|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a telomere specific protein which is a component of the telomere nucleoprotein complex. This protein is present at telomeres throughout the cell cycle and functions as an inhibitor of telomerase, acting in cis to limit the elongation of individual chromosome ends. The protein structure contains a C-terminal Myb motif, a dimerization domain near its N-terminus and an acidic N-terminus. Two transcripts of this gene are alternatively spliced products. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double- stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. {ECO:0000269|PubMed:16166375}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TRF|
|Myb DNA-binding|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of shelterin complex assembly|
|negative regulation of establishment of RNA localization to telomere|
|regulation of establishment of protein-containing complex localization to telomere|
|negative regulation of establishment of protein-containing complex localization to telomere|
|regulation of establishment of RNA localization to telomere|
|negative regulation of establishment of protein localization to telomere|
|positive regulation of shelterin complex assembly|
|negative regulation of telomeric D-loop disassembly|
|negative regulation of protein localization to chromosome, telomeric region|
|negative regulation of exonuclease activity|
|regulation of telomeric D-loop disassembly|
|negative regulation of telomere maintenance via semi-conservative replication|
|negative regulation of telomeric loop disassembly|
|regulation of telomere maintenance via semi-conservative replication|
|regulation of telomeric loop disassembly|
|regulation of exonuclease activity|
|negative regulation of nuclear cell cycle DNA replication|
|ankyrin repeat binding|
|telomerase activity|
|negative regulation of nuclease activity|
|shelterin complex|
|telomeric D-loop disassembly|
|nuclear telomere cap complex|
|double-stranded telomeric DNA binding|
|G-rich strand telomeric DNA binding|
|formation of extrachromosomal circular DNA|
|t-circle formation|
|regulation of establishment of protein localization to telomere|
|telomere maintenance via telomere trimming|
|meiotic telomere clustering|
|regulation of establishment of protein localization to chromosome|
|telomeric loop disassembly|
|chromosome localization to nuclear envelope involved in homologous chromosome segregation|
|negative regulation of telomerase activity|
|telomere localization|
|regulation of protein localization to chromosome, telomeric region|
|regulation of nuclear cell cycle DNA replication|
|telomere capping|
|DNA binding, bending|
|negative regulation of telomere maintenance via telomerase|
|regulation of nuclease activity|
|telomere maintenance via telomerase|
|negative regulation of DNA-dependent DNA replication|
|negative regulation of telomere maintenance via telomere lengthening|
|telomeric DNA binding|
|telomere maintenance via telomere lengthening|
|positive regulation of microtubule polymerization|
|positive regulation of microtubule polymerization or depolymerization|
|RNA-dependent DNA biosynthetic process|
|negative regulation of telomere maintenance|
|negative regulation of DNA biosynthetic process|
|negative regulation of DNA replication|
|regulation of telomerase activity|
|regulation of microtubule polymerization|
|regulation of telomere maintenance via telomerase|
|regulation of DNA-dependent DNA replication|
|homologous chromosome segregation|
|regulation of telomere maintenance via telomere lengthening|
|chromosome organization involved in meiotic cell cycle|
|establishment of chromosome localization|
|chromosome localization|
|regulation of microtubule polymerization or depolymerization|
|regulation of telomere maintenance|
|meiotic chromosome segregation|
|telomere maintenance|
|telomere organization|
|regulation of DNA replication|
|nuclear chromosome, telomeric region|
|DNA biosynthetic process|
|meiosis I|
|regulation of DNA biosynthetic process|
|meiosis I cell cycle process|
|negative regulation of cellular protein localization|
|spindle|
|negative regulation of DNA metabolic process|
|positive regulation of protein polymerization|
|fibrillar center|
|negative regulation of chromosome organization|
|meiotic nuclear division|
|meiotic cell cycle process|
|positive regulation of chromosome organization|
|negative regulation of establishment of protein localization|
|regulation of microtubule cytoskeleton organization|
|positive regulation of supramolecular fiber organization|
|nuclear chromosome segregation|
|positive regulation of cytoskeleton organization|
|regulation of microtubule-based process|
|meiotic cell cycle|
|regulation of protein polymerization|
|microtubule binding|
|positive regulation of protein complex assembly|
|chromosome segregation|
|negative regulation of transferase activity|
|nuclear body|
|nuclear division|
|organelle fission|
|negative regulation of cell cycle process|
|protein homooligomerization|
|anatomical structure homeostasis|
|regulation of chromosome organization|
|regulation of supramolecular fiber organization|
|regulation of DNA metabolic process|
|establishment of organelle localization|
|negative regulation of organelle organization|
|regulation of protein complex assembly|
|negative regulation of hydrolase activity|
|cell division|
|protein complex oligomerization|
|positive regulation of cellular component biogenesis|
|regulation of cellular protein localization|
|regulation of cytoskeleton organization|
|negative regulation of cell cycle|
|organelle localization|
|positive regulation of organelle organization|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|positive regulation of cell death|
|negative regulation of cellular component organization|
|DNA metabolic process|
|regulation of establishment of protein localization|
|regulation of cell cycle process|
|negative regulation of catalytic activity|
|nucleolus|
|protein homodimerization activity|
|regulation of cellular localization|
|regulation of cellular component biogenesis|
|regulation of transferase activity|
|cell cycle process|
|response to drug|
|regulation of protein localization|
|chromosome organization|
|nucleobase-containing compound biosynthetic process|
|negative regulation of molecular function|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|regulation of hydrolase activity|
|regulation of organelle organization|
|organic cyclic compound biosynthetic process|
|cell cycle|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|protein-containing complex assembly|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|cellular nitrogen compound biosynthetic process|
|homeostatic process|
|regulation of cell death|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|establishment of localization in cell|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|-1.89|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|-1.74|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|2|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:terf2|TERF2]]|0.497|
|[[:human genes:o:ogfr|OGFR]]|0.495|
|[[:human genes:c:chd4|CHD4]]|0.49|
|[[:human genes:r:rps12|RPS12]]|0.49|
|[[:human genes:n:nol10|NOL10]]|0.488|
|[[:human genes:s:smg7|SMG7]]|0.477|
|[[:human genes:k:kctd17|KCTD17]]|0.472|
|[[:human genes:t:twistnb|TWISTNB]]|0.472|
|[[:human genes:h:hmgcr|HMGCR]]|0.468|
|[[:human genes:o:orc1|ORC1]]|0.464|
|[[:human genes:v:vasn|VASN]]|0.459|
|[[:human genes:a:acbd4|ACBD4]]|0.458|
|[[:human genes:s:scaf1|SCAF1]]|0.456|
|[[:human genes:h:htatsf1|HTATSF1]]|0.449|
|[[:human genes:p:pan3|PAN3]]|0.448|
|[[:human genes:p:psma6|PSMA6]]|0.448|
|[[:human genes:d:dtl|DTL]]|0.448|
|[[:human genes:d:disp2|DISP2]]|0.442|
|[[:human genes:h:hap1|HAP1]]|0.431|
|[[:human genes:p:psmb4|PSMB4]]|0.431|
|[[:human genes:p:psmd11|PSMD11]]|0.43|
|[[:human genes:p:ppm1d|PPM1D]]|0.43|
|[[:human genes:x:xylt2|XYLT2]]|0.43|
|[[:human genes:p:pole2|POLE2]]|0.429|
|[[:human genes:p:pcf11|PCF11]]|0.429|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.429|
|[[:human genes:z:zfand5|ZFAND5]]|0.428|
|[[:human genes:c:cep192|CEP192]]|0.427|
|[[:human genes:t:tspy8|TSPY8]]|0.424|
|[[:human genes:r:rpl17|RPL17]]|0.423|
|[[:human genes:b:brd2|BRD2]]|0.42|
|[[:human genes:m:myh7b|MYH7B]]|0.42|
|[[:human genes:c:cactin|CACTIN]]|0.418|
|[[:human genes:s:sf3a1|SF3A1]]|0.418|
|[[:human genes:b:bysl|BYSL]]|0.417|
|[[:human genes:r:rps2|RPS2]]|0.416|
|[[:human genes:e:exosc5|EXOSC5]]|0.415|
|[[:human genes:p:psmb1|PSMB1]]|0.414|
|[[:human genes:s:sf3b4|SF3B4]]|0.413|
|[[:human genes:n:nop16|NOP16]]|0.412|
|[[:human genes:m:madcam1|MADCAM1]]|0.411|
|[[:human genes:r:rpl35|RPL35]]|0.411|
|[[:human genes:a:akirin2|AKIRIN2]]|0.411|
|[[:human genes:r:rrm1|RRM1]]|0.41|
|[[:human genes:n:narfl|NARFL]]|0.409|
|[[:human genes:z:znf830|ZNF830]]|0.408|
|[[:human genes:r:rpa2|RPA2]]|0.406|
|[[:human genes:s:smg1|SMG1]]|0.405|
|[[:human genes:z:znf655|ZNF655]]|0.405|
|[[:human genes:h:hist2h2aa4|HIST2H2AA4]]|0.404|
|[[:human genes:h:hist2h2aa3|HIST2H2AA3]]|0.404|
|[[:human genes:r:rpl14|RPL14]]|0.403|
|[[:human genes:i:ik|IK]]|0.403|
|[[:human genes:r:riok2|RIOK2]]|0.402|
|[[:human genes:r:rpl26|RPL26]]|0.402|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.401|
|[[:human genes:t:top1mt|TOP1MT]]|0.4|
|[[:human genes:t:tceb3c|TCEB3C]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 99/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|2/28|
|bone|4/25|
|breast|2/33|
|central nervous system|8/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|2/15|
|kidney|10/21|
|liver|1/20|
|lung|10/75|
|lymphocyte|0/14|
|ovary|5/26|
|pancreas|1/24|
|peripheral nervous system|1/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|9/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|4/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1848
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.86 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TERF1 Expression in NALM6 Cells: 5.86'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>