TFAP2A [The Human Chemical-Genetic Interaction Map Project]

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======= TFAP2A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TFAP2A
  * **<color #00a2e8>Official Name</color>**: transcription factor AP-2 alpha
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7020|7020]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P05549|P05549]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TFAP2A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TFAP2A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/107580|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a transcription factor that binds the consensus sequence 5'-GCCNNNGGC-3'. The encoded protein functions as either a homodimer or as a heterodimer with similar family members. This protein activates the transcription of some genes while inhibiting the transcription of others. Defects in this gene are a cause of branchiooculofacial syndrome (BOFS). Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Dec 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region. {ECO:0000269|PubMed:11694877, ECO:0000269|PubMed:12586840}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TF AP-2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|optic cup structural organization|
|oculomotor nerve morphogenesis|
|optic vesicle morphogenesis|
|oculomotor nerve formation|
|oculomotor nerve development|
|positive regulation of tooth mineralization|
|optic cup morphogenesis involved in camera-type eye development|
|cranial nerve formation|
|regulation of tooth mineralization|
|negative regulation of transcription by competitive promoter binding|
|cellular response to iron ion|
|positive regulation of odontogenesis|
|embryonic camera-type eye formation|
|trigeminal nerve development|
|eyelid development in camera-type eye|
|anatomical structure arrangement|
|preganglionic parasympathetic fiber development|
|parasympathetic nervous system development|
|retina layer formation|
|embryonic camera-type eye morphogenesis|
|regulation of odontogenesis|
|cranial nerve morphogenesis|
|proximal promoter sequence-specific DNA binding|
|response to iron ion|
|embryonic forelimb morphogenesis|
|embryonic eye morphogenesis|
|embryonic camera-type eye development|
|positive regulation of bone mineralization|
|forelimb morphogenesis|
|embryonic cranial skeleton morphogenesis|
|autonomic nervous system development|
|positive regulation of biomineral tissue development|
|positive regulation of biomineralization|
|retina morphogenesis in camera-type eye|
|cranial nerve development|
|negative regulation of reactive oxygen species metabolic process|
|positive regulation of neuron apoptotic process|
|neural retina development|
|cranial skeletal system development|
|regulation of bone mineralization|
|transcription regulatory region sequence-specific DNA binding|
|nerve development|
|positive regulation of animal organ morphogenesis|
|positive regulation of ossification|
|roof of mouth development|
|positive regulation of neuron death|
|regulation of biomineral tissue development|
|regulation of biomineralization|
|embryonic skeletal system morphogenesis|
|inner ear morphogenesis|
|camera-type eye morphogenesis|
|bone morphogenesis|
|ear morphogenesis|
|embryonic appendage morphogenesis|
|embryonic limb morphogenesis|
|embryonic skeletal system development|
|retina development in camera-type eye|
|morphogenesis of embryonic epithelium|
|sensory perception of sound|
|eye morphogenesis|
|limb morphogenesis|
|appendage morphogenesis|
|protein dimerization activity|
|sensory perception of mechanical stimulus|
|regulation of reactive oxygen species metabolic process|
|limb development|
|appendage development|
|regulation of ossification|
|cellular response to metal ion|
|inner ear development|
|bone development|
|regulation of neuron apoptotic process|
|transcription regulatory region DNA binding|
|cellular response to inorganic substance|
|ear development|
|skeletal system morphogenesis|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|sensory organ morphogenesis|
|regulation of animal organ morphogenesis|
|kidney development|
|transcription coactivator activity|
|renal system development|
|embryonic organ morphogenesis|
|regulation of neuron death|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|camera-type eye development|
|urogenital system development|
|eye development|
|visual system development|
|sensory system development|
|response to metal ion|
|chromatin binding|
|sequence-specific DNA binding|
|morphogenesis of an epithelium|
|embryonic organ development|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|centrosome|
|skeletal system development|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|response to inorganic substance|
|sensory organ development|
|tissue morphogenesis|
|embryonic morphogenesis|
|chordate embryonic development|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|embryo development ending in birth or egg hatching|
|negative regulation of cell population proliferation|
|intracellular membrane-bounded organelle|
|positive regulation of cell death|
|negative regulation of transcription by RNA polymerase II|
|protein homodimerization activity|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|negative regulation of programmed cell death|
|animal organ morphogenesis|
|sensory perception|
|embryo development|
|central nervous system development|
|Golgi apparatus|
|negative regulation of cell death|
|regulation of anatomical structure morphogenesis|
|epithelium development|
|negative regulation of transcription, DNA-templated|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|positive regulation of developmental process|
|nervous system process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of cell death|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of cell differentiation|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 5/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13534
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.71 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TFAP2A Expression in NALM6 Cells: -0.71'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>