TFAP4 [The Human Chemical-Genetic Interaction Map Project]

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======= TFAP4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TFAP4
  * **<color #00a2e8>Official Name</color>**: transcription factor AP-4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7023|7023]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q01664|Q01664]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TFAP4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TFAP4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600743|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Transcription factor that activates both viral and cellular genes by binding to the symmetrical DNA sequence 5'- CAGCTG-3'.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HLH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway|
|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|
|negative regulation by host of viral transcription|
|DNA damage response, signal transduction resulting in transcription|
|positive regulation by host of viral transcription|
|regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway|
|negative regulation of cell cycle arrest|
|negative regulation of viral transcription|
|negative regulation of cyclin-dependent protein serine/threonine kinase activity|
|cellular response to dexamethasone stimulus|
|negative regulation of cyclin-dependent protein kinase activity|
|response to dexamethasone|
|positive regulation of viral transcription|
|E-box binding|
|negative regulation of DNA binding|
|cellular response to glucocorticoid stimulus|
|transcriptional repressor complex|
|cellular response to corticosteroid stimulus|
|regulation of viral transcription|
|modification by host of symbiont morphology or physiology|
|interaction with symbiont|
|DNA damage response, signal transduction by p53 class mediator|
|cellular response to ketone|
|response to antineoplastic agent|
|negative regulation of viral process|
|regulation of cyclin-dependent protein serine/threonine kinase activity|
|regulation of cyclin-dependent protein kinase activity|
|signal transduction in response to DNA damage|
|regulation of cell cycle arrest|
|positive regulation of viral process|
|modification of morphology or physiology of other organism involved in symbiotic interaction|
|histone deacetylase binding|
|signal transduction by p53 class mediator|
|regulation of DNA binding|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|negative regulation of protein serine/threonine kinase activity|
|response to glucocorticoid|
|positive regulation of cysteine-type endopeptidase activity|
|modification of morphology or physiology of other organism|
|response to corticosteroid|
|negative regulation of binding|
|positive regulation of endopeptidase activity|
|positive regulation of apoptotic signaling pathway|
|cellular response to xenobiotic stimulus|
|cellular response to steroid hormone stimulus|
|positive regulation of peptidase activity|
|response to ketone|
|regulation of viral process|
|negative regulation of multi-organism process|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|transcription regulatory region DNA binding|
|regulation of symbiosis, encompassing mutualism through parasitism|
|negative regulation of protein kinase activity|
|regulation of cysteine-type endopeptidase activity|
|negative regulation of kinase activity|
|negative regulation of transferase activity|
|transcription coactivator activity|
|response to xenobiotic stimulus|
|negative regulation of cell cycle process|
|response to steroid hormone|
|positive regulation of proteolysis|
|positive regulation of cell cycle|
|regulation of binding|
|regulation of apoptotic signaling pathway|
|cellular response to drug|
|negative regulation of protein phosphorylation|
|regulation of mitotic cell cycle phase transition|
|regulation of endopeptidase activity|
|sequence-specific DNA binding|
|regulation of peptidase activity|
|negative regulation of phosphorylation|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|regulation of cell cycle phase transition|
|protein heterodimerization activity|
|positive regulation of multi-organism process|
|regulation of protein serine/threonine kinase activity|
|cellular response to lipid|
|cellular response to organic cyclic compound|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of cell cycle|
|negative regulation of protein modification process|
|cellular response to hormone stimulus|
|regulation of mitotic cell cycle|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|negative regulation of cell population proliferation|
|DNA-binding transcription factor activity|
|positive regulation of cell death|
|regulation of proteolysis|
|regulation of cell cycle process|
|positive regulation of hydrolase activity|
|regulation of multi-organism process|
|cellular response to DNA damage stimulus|
|symbiotic process|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|interspecies interaction between organisms|
|response to lipid|
|regulation of kinase activity|
|protein homodimerization activity|
|response to hormone|
|response to organic cyclic compound|
|regulation of transferase activity|
|response to drug|
|negative regulation of cellular protein metabolic process|
|cellular response to oxygen-containing compound|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|mitochondrion|
|regulation of hydrolase activity|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp504|MK2206 4μM R08 exp504]]|-2.54|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-2.08|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-2.01|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|-1.79|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-1.79|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-1.73|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|1.71|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|1.78|
|[[:results:exp534|Trientine 500μM R08 exp534]]|2.05|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|2.12|
|[[:results:exp59|UMK57 1μM R01 exp59]]|2.17|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|2.34|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|2.38|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|2.57|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|2.58|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|2.61|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|3.29|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|3.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:ccnf|CCNF]]|0.423|
|[[:human genes:c:ctdspl2|CTDSPL2]]|0.408|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 11/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|2/28|
|bone|0/26|
|breast|1/33|
|central nervous system|2/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1434
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.74 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TFAP4 Expression in NALM6 Cells: 5.74'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>