TFEB [The Human Chemical-Genetic Interaction Map Project]

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======= TFEB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TFEB
  * **<color #00a2e8>Official Name</color>**: transcription factor EB
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7942|7942]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P19484|P19484]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TFEB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TFEB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600744|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Transcription factor that specifically recognizes and binds E-box sequences (5'-CANNTG-3'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T- cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression. It thereby plays a central role in expression of lysosomal genes. Acts as a positive regulator of autophagy by promoting expression of genes involved in autophagy. Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer. Plays a role in the signal transduction processes required for normal vascularization of the placenta. {ECO:0000269|PubMed:19556463, ECO:0000269|PubMed:23434374}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF3371|
|HLH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|lysosome localization|
|lytic vacuole organization|
|lysosome organization|
|embryonic placenta development|
|positive regulation of autophagy|
|vacuole organization|
|placenta development|
|protein dimerization activity|
|transcription regulatory region DNA binding|
|autophagy|
|process utilizing autophagic mechanism|
|regulation of autophagy|
|humoral immune response|
|positive regulation of cellular catabolic process|
|in utero embryonic development|
|reproductive structure development|
|reproductive system development|
|positive regulation of catabolic process|
|embryonic organ development|
|organelle localization|
|adaptive immune response|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|developmental process involved in reproduction|
|DNA-binding transcription factor activity|
|regulation of cellular catabolic process|
|embryo development|
|regulation of catabolic process|
|positive regulation of transcription by RNA polymerase II|
|reproductive process|
|reproduction|
|positive regulation of transcription, DNA-templated|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of RNA metabolic process|
|cellular catabolic process|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp210|LB-100 2μM R05 exp210]]|-1.89|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-1.88|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-1.86|
|[[:results:exp359|FK-506 30μM R07 exp359]]|-1.85|
|[[:results:exp70|INK128 0.2μM R02 exp70]]|-1.81|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-1.8|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|-1.79|
|[[:results:exp72|LB-100 4.1μM R02 exp72]]|-1.78|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-1.74|
|[[:results:exp484|GSK-J5 1.5μM R08 exp484]]|-1.73|
|[[:results:exp486|Heregulin-B 44ng/ml R08 exp486]]|-1.73|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|1.89|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|1.99|
|[[:results:exp155|UNC1999 2μM R03 exp155]]|2.13|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7589
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.0 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TFEB Expression in NALM6 Cells: 4.0'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>