TGFB2 [The Human Chemical-Genetic Interaction Map Project]

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======= TGFB2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TGFB2
  * **<color #00a2e8>Official Name</color>**: transforming growth factor beta 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7042|7042]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P61812|P61812]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TGFB2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TGFB2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/190220|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. Disruption of the TGF-beta/SMAD pathway has been implicated in a variety of human cancers. A chromosomal translocation that includes this gene is associated with Peters' anomaly, a congenital defect of the anterior chamber of the eye. Mutations in this gene may be associated with Loeys-Dietz syndrome. This gene encodes multiple isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Aug 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  TGF-beta 2 has suppressive effects on interleukin-2 dependent T-cell growth.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TGFb propeptide|
|TGF beta|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|substantia propria of cornea development|
|uterine wall breakdown|
|negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation|
|negative regulation of cardiac epithelial to mesenchymal transition|
|regulation of apoptotic process involved in outflow tract morphogenesis|
|positive regulation of timing of catagen|
|type III transforming growth factor beta receptor binding|
|positive regulation of integrin biosynthetic process|
|negative regulation of alkaline phosphatase activity|
|regulation of integrin biosynthetic process|
|endocardial cushion fusion|
|ascending aorta morphogenesis|
|regulation of timing of catagen|
|positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation|
|cell adhesion involved in heart morphogenesis|
|negative regulation of macrophage cytokine production|
|positive regulation of hair follicle maturation|
|atrial septum primum morphogenesis|
|ascending aorta development|
|septum primum development|
|positive regulation of cardioblast differentiation|
|type II transforming growth factor beta receptor binding|
|regulation of epithelial to mesenchymal transition involved in endocardial cushion formation|
|pharyngeal arch artery morphogenesis|
|regulation of cardioblast differentiation|
|regulation of transforming growth factor beta2 production|
|positive regulation of cardiac epithelial to mesenchymal transition|
|regulation of alkaline phosphatase activity|
|regulation of hair follicle maturation|
|dopamine biosynthetic process|
|membranous septum morphogenesis|
|regulation of complement-dependent cytotoxicity|
|regulation of cardiac epithelial to mesenchymal transition|
|regulation of apoptotic process involved in morphogenesis|
|positive regulation of hair follicle development|
|regulation of apoptotic process involved in development|
|positive regulation of hair cycle|
|pathway-restricted SMAD protein phosphorylation|
|cardioblast differentiation|
|cardiac muscle cell proliferation|
|regulation of macrophage cytokine production|
|regulation of plasma membrane organization|
|striated muscle cell proliferation|
|atrial septum morphogenesis|
|ventricular trabecula myocardium morphogenesis|
|pulmonary valve morphogenesis|
|muscle cell proliferation|
|catecholamine biosynthetic process|
|catechol-containing compound biosynthetic process|
|regulation of hair follicle development|
|positive regulation of cell adhesion mediated by integrin|
|cardiac right ventricle morphogenesis|
|atrial septum development|
|positive regulation of stem cell differentiation|
|pulmonary valve development|
|uterus development|
|somatic stem cell division|
|atrioventricular valve morphogenesis|
|secondary palate development|
|hair follicle morphogenesis|
|negative regulation of cytokine production involved in immune response|
|pharyngeal system development|
|atrioventricular valve development|
|cardiac muscle tissue growth|
|negative regulation of epithelial to mesenchymal transition|
|regulation of hair cycle|
|heart growth|
|cardiac epithelial to mesenchymal transition|
|aorta morphogenesis|
|outflow tract septum morphogenesis|
|positive regulation of cardiocyte differentiation|
|epidermis morphogenesis|
|salivary gland morphogenesis|
|dopamine metabolic process|
|cardiac atrium morphogenesis|
|positive regulation of pri-miRNA transcription by RNA polymerase II|
|heart trabecula morphogenesis|
|salivary gland development|
|stem cell division|
|embryonic digestive tract development|
|negative regulation of animal organ morphogenesis|
|phenol-containing compound biosynthetic process|
|regulation of transforming growth factor beta production|
|cardiac atrium development|
|endocardial cushion morphogenesis|
|negative regulation of production of molecular mediator of immune response|
|glial cell migration|
|semi-lunar valve development|
|positive regulation of heart contraction|
|positive regulation of epidermis development|
|regulation of heart morphogenesis|
|ventricular septum morphogenesis|
|transforming growth factor beta receptor binding|
|regulation of pri-miRNA transcription by RNA polymerase II|
|exocrine system development|
|endocardial cushion development|
|ovulation cycle process|
|catechol-containing compound metabolic process|
|catecholamine metabolic process|
|response to progesterone|
|trabecula morphogenesis|
|regulation of cell adhesion mediated by integrin|
|collagen fibril organization|
|positive regulation of epithelial to mesenchymal transition|
|ventricular cardiac muscle tissue morphogenesis|
|positive regulation of pathway-restricted SMAD protein phosphorylation|
|mesenchyme morphogenesis|
|regulation of cardiocyte differentiation|
|aorta development|
|negative regulation of Ras protein signal transduction|
|heart valve morphogenesis|
|positive regulation of Notch signaling pathway|
|positive regulation of neuron apoptotic process|
|ventricular cardiac muscle tissue development|
|SMAD protein signal transduction|
|neural retina development|
|negative regulation of small GTPase mediated signal transduction|
|artery morphogenesis|
|heart valve development|
|regulation of pathway-restricted SMAD protein phosphorylation|
|cranial skeletal system development|
|platelet alpha granule lumen|
|ovulation cycle|
|cardiac muscle tissue morphogenesis|
|epithelial to mesenchymal transition|
|positive regulation of blood circulation|
|hair follicle development|
|ventricular septum development|
|cardiac ventricle morphogenesis|
|skin epidermis development|
|outflow tract morphogenesis|
|cardiac septum morphogenesis|
|hair cycle process|
|molting cycle process|
|muscle tissue morphogenesis|
|amyloid-beta binding|
|positive regulation of animal organ morphogenesis|
|neutrophil chemotaxis|
|regulation of epithelial to mesenchymal transition|
|phenol-containing compound metabolic process|
|positive regulation of ossification|
|regulation of cytokine production involved in immune response|
|regulation of epidermis development|
|artery development|
|positive regulation of phosphatidylinositol 3-kinase signaling|
|positive regulation of cell division|
|muscle organ morphogenesis|
|granulocyte chemotaxis|
|roof of mouth development|
|neural tube closure|
|tube closure|
|hair cycle|
|neutrophil migration|
|positive regulation of neuron death|
|molting cycle|
|organ growth|
|extrinsic apoptotic signaling pathway|
|primary neural tube formation|
|gland morphogenesis|
|granulocyte migration|
|regulation of cell killing|
|regulation of Notch signaling pathway|
|transforming growth factor beta receptor signaling pathway|
|negative regulation of angiogenesis|
|positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|negative regulation of phosphatase activity|
|negative regulation of blood vessel morphogenesis|
|neural tube formation|
|cardiac septum development|
|negative regulation of dephosphorylation|
|negative regulation of vasculature development|
|cardiocyte differentiation|
|regulation of stem cell differentiation|
|regulation of phosphatidylinositol 3-kinase signaling|
|negative regulation of immune effector process|
|odontogenesis|
|embryonic epithelial tube formation|
|negative regulation of epithelial cell proliferation|
|embryonic limb morphogenesis|
|embryonic appendage morphogenesis|
|cardiac chamber morphogenesis|
|myeloid leukocyte migration|
|cardiac ventricle development|
|platelet degranulation|
|digestive tract development|
|epithelial tube formation|
|male gonad development|
|development of primary male sexual characteristics|
|cell-cell junction organization|
|retina development in camera-type eye|
|positive regulation of epithelial cell migration|
|regulation of production of molecular mediator of immune response|
|digestive system development|
|leukocyte chemotaxis|
|morphogenesis of embryonic epithelium|
|cell cycle arrest|
|tube formation|
|negative regulation of immune response|
|appendage morphogenesis|
|limb morphogenesis|
|cellular response to transforming growth factor beta stimulus|
|mesenchymal cell differentiation|
|male sex differentiation|
|stem cell differentiation|
|neural tube development|
|response to transforming growth factor beta|
|cardiac muscle tissue development|
|positive regulation of cell growth|
|growth factor activity|
|positive regulation of stress-activated MAPK cascade|
|positive regulation of stress-activated protein kinase signaling cascade|
|regulation of cell division|
|cardiac chamber development|
|cytokine activity|
|regulation of phosphatase activity|
|appendage development|
|limb development|
|negative regulation of cell growth|
|organic hydroxy compound biosynthetic process|
|regulation of ossification|
|response to ketone|
|inner ear development|
|ammonium ion metabolic process|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|regulation of neuron apoptotic process|
|cell chemotaxis|
|gonad development|
|regulation of dephosphorylation|
|cell junction organization|
|gliogenesis|
|development of primary sexual characteristics|
|regulation of epithelial cell migration|
|ear development|
|mesenchyme development|
|regulation of stress-activated MAPK cascade|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|regulation of stress-activated protein kinase signaling cascade|
|negative regulation of growth|
|regulation of Ras protein signal transduction|
|regulation of heart contraction|
|heart morphogenesis|
|regulation of animal organ morphogenesis|
|positive regulation of growth|
|cell-cell adhesion via plasma-membrane adhesion molecules|
|sex differentiation|
|kidney development|
|positive regulation of protein secretion|
|negative regulation of cytokine production|
|rhythmic process|
|renal system development|
|striated muscle tissue development|
|apoptotic signaling pathway|
|regulation of angiogenesis|
|regulation of blood circulation|
|positive regulation of peptide secretion|
|muscle organ development|
|axon|
|muscle tissue development|
|epithelial tube morphogenesis|
|regulation of neuron death|
|camera-type eye development|
|angiogenesis|
|urogenital system development|
|regulation of vasculature development|
|response to steroid hormone|
|activation of protein kinase activity|
|regulation of epithelial cell proliferation|
|signaling receptor binding|
|extracellular matrix organization|
|response to hypoxia|
|regulation of small GTPase mediated signal transduction|
|response to decreased oxygen levels|
|eye development|
|visual system development|
|collagen-containing extracellular matrix|
|sensory system development|
|neuronal cell body|
|positive regulation of cell cycle|
|leukocyte migration|
|response to oxygen levels|
|skin development|
|extracellular structure organization|
|developmental growth|
|growth|
|positive regulation of secretion by cell|
|positive regulation of cell adhesion|
|blood vessel morphogenesis|
|gland development|
|epidermis development|
|regulation of cell growth|
|positive regulation of protein transport|
|reproductive structure development|
|reproductive system development|
|morphogenesis of an epithelium|
|embryonic organ development|
|positive regulation of secretion|
|negative regulation of immune system process|
|negative regulation of hydrolase activity|
|organic hydroxy compound metabolic process|
|supramolecular fiber organization|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|regulation of immune effector process|
|muscle structure development|
|wound healing|
|blood vessel development|
|protein heterodimerization activity|
|cell division|
|regulation of peptide secretion|
|skeletal system development|
|positive regulation of cell migration|
|drug metabolic process|
|cellular response to growth factor stimulus|
|cell-cell adhesion|
|negative regulation of intracellular signal transduction|
|vasculature development|
|cardiovascular system development|
|positive regulation of cell motility|
|heart development|
|response to growth factor|
|positive regulation of protein kinase activity|
|positive regulation of cellular component movement|
|positive regulation of MAPK cascade|
|sensory organ development|
|chemotaxis|
|taxis|
|positive regulation of locomotion|
|cell population proliferation|
|hemopoiesis|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|tissue morphogenesis|
|embryonic morphogenesis|
|response to wounding|
|negative regulation of cell cycle|
|positive regulation of kinase activity|
|regulation of system process|
|hematopoietic or lymphoid organ development|
|chordate embryonic development|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|immune system development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|positive regulation of transferase activity|
|developmental process involved in reproduction|
|regulation of growth|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|regulation of cytokine production|
|positive regulation of cell death|
|regulated exocytosis|
|regulation of protein transport|
|negative regulation of cell differentiation|
|enzyme linked receptor protein signaling pathway|
|cell morphogenesis|
|regulation of cellular response to stress|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|negative regulation of catalytic activity|
|exocytosis|
|regulation of protein kinase activity|
|regulation of secretion|
|neuron development|
|cellular component morphogenesis|
|multicellular organismal reproductive process|
|multicellular organism reproduction|
|tube development|
|regulation of cell migration|
|response to lipid|
|positive regulation of immune response|
|circulatory system development|
|regulation of kinase activity|
|protein homodimerization activity|
|anatomical structure formation involved in morphogenesis|
|response to hormone|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|apoptotic process|
|cell adhesion|
|biological adhesion|
|negative regulation of developmental process|
|animal organ morphogenesis|
|cell migration|
|positive regulation of cell differentiation|
|protein phosphorylation|
|regulation of transferase activity|
|embryo development|
|regulation of locomotion|
|positive regulation of transport|
|regulation of cellular component movement|
|cell cycle process|
|secretion by cell|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|response to drug|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|export from cell|
|programmed cell death|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|localization of cell|
|cell motility|
|cell death|
|epithelium development|
|secretion|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of molecular function|
|regulation of immune response|
|positive regulation of immune system process|
|response to abiotic stimulus|
|aromatic compound biosynthetic process|
|regulation of cell cycle|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|phosphorylation|
|organic cyclic compound biosynthetic process|
|locomotion|
|cell cycle|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|organonitrogen compound biosynthetic process|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of response to stress|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|positive regulation of signal transduction|
|regulation of immune system process|
|regulation of cell death|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|vesicle-mediated transport|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|-1.81|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|1.73|
|[[:results:exp461|BS-181 20μM R08 exp461]]|1.76|
|[[:results:exp303|39°C R06 exp303]]|1.84|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15191
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.32 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TGFB2 Expression in NALM6 Cells: -0.32'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>