TGFBR3 [The Human Chemical-Genetic Interaction Map Project]

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======= TGFBR3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TGFBR3
  * **<color #00a2e8>Official Name</color>**: transforming growth factor beta receptor 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7049|7049]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q03167|Q03167]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TGFBR3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TGFBR3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600742|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This locus encodes the transforming growth factor (TGF)-beta type III receptor. The encoded receptor is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.[provided by RefSeq, Sep 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Zona pellucida|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|transforming growth factor beta receptor activity, type III|
|definitive erythrocyte differentiation|
|transforming growth factor beta receptor complex assembly|
|cardiac fibroblast cell development|
|epicardium-derived cardiac fibroblast cell development|
|inhibin-betaglycan-ActRII complex|
|epicardium-derived cardiac fibroblast cell differentiation|
|cardiac fibroblast cell differentiation|
|response to luteinizing hormone|
|vasculogenesis involved in coronary vascular morphogenesis|
|muscular septum morphogenesis|
|type II transforming growth factor beta receptor binding|
|ventricular compact myocardium morphogenesis|
|pathway-restricted SMAD protein phosphorylation|
|heart trabecula formation|
|activin binding|
|cardiac muscle cell proliferation|
|striated muscle cell proliferation|
|transforming growth factor beta-activated receptor activity|
|response to follicle-stimulating hormone|
|coronary vasculature morphogenesis|
|definitive hemopoiesis|
|muscle cell proliferation|
|transforming growth factor beta binding|
|trabecula formation|
|fibroblast growth factor binding|
|response to prostaglandin E|
|secondary palate development|
|glycosaminoglycan binding|
|positive regulation of cardiac muscle cell proliferation|
|cardiac muscle tissue growth|
|cardiac epithelial to mesenchymal transition|
|heart growth|
|response to gonadotropin|
|positive regulation of cellular response to transforming growth factor beta stimulus|
|positive regulation of transforming growth factor beta receptor signaling pathway|
|response to prostaglandin|
|heart trabecula morphogenesis|
|positive regulation of cardiac muscle tissue growth|
|coreceptor activity|
|positive regulation of heart growth|
|regulation of cardiac muscle cell proliferation|
|ventricular septum morphogenesis|
|transforming growth factor beta receptor binding|
|positive regulation of cardiac muscle tissue development|
|coronary vasculature development|
|trabecula morphogenesis|
|ventricular cardiac muscle tissue morphogenesis|
|positive regulation of organ growth|
|SMAD binding|
|ventricular cardiac muscle tissue development|
|regulation of cardiac muscle tissue growth|
|regulation of heart growth|
|cardiac cell development|
|cardiac muscle tissue morphogenesis|
|vasculogenesis|
|positive regulation of striated muscle tissue development|
|positive regulation of muscle organ development|
|epithelial to mesenchymal transition|
|positive regulation of muscle tissue development|
|ventricular septum development|
|cardiac septum morphogenesis|
|outflow tract morphogenesis|
|negative regulation of transforming growth factor beta receptor signaling pathway|
|animal organ regeneration|
|cardiac ventricle morphogenesis|
|negative regulation of cellular response to transforming growth factor beta stimulus|
|regulation of cardiac muscle tissue development|
|muscle tissue morphogenesis|
|erythrocyte differentiation|
|response to fatty acid|
|muscle organ morphogenesis|
|PDZ domain binding|
|erythrocyte homeostasis|
|BMP signaling pathway|
|roof of mouth development|
|regulation of organ growth|
|organ growth|
|transforming growth factor beta receptor signaling pathway|
|positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|cellular response to BMP stimulus|
|response to BMP|
|myeloid cell homeostasis|
|cardiac septum development|
|regulation of transforming growth factor beta receptor signaling pathway|
|cardiocyte differentiation|
|regulation of cellular response to transforming growth factor beta stimulus|
|negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|negative regulation of epithelial cell proliferation|
|liver development|
|cardiac chamber morphogenesis|
|cardiac ventricle development|
|hepaticobiliary system development|
|regulation of striated muscle tissue development|
|regulation of muscle tissue development|
|regulation of muscle organ development|
|negative regulation of cellular response to growth factor stimulus|
|cellular response to transforming growth factor beta stimulus|
|regeneration|
|mesenchymal cell differentiation|
|cardiac muscle tissue development|
|response to transforming growth factor beta|
|heparin binding|
|cardiac chamber development|
|positive regulation of developmental growth|
|regulation of JNK cascade|
|response to ketone|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|homeostasis of number of cells|
|receptor complex|
|regulation of protein binding|
|myeloid cell differentiation|
|mesenchyme development|
|extracellular matrix|
|response to alcohol|
|regulation of stress-activated MAPK cascade|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|regulation of stress-activated protein kinase signaling cascade|
|heart morphogenesis|
|positive regulation of growth|
|regulation of cellular response to growth factor stimulus|
|striated muscle tissue development|
|regulation of ERK1 and ERK2 cascade|
|muscle organ development|
|muscle tissue development|
|negative regulation of cellular component movement|
|regulation of developmental growth|
|regulation of epithelial cell proliferation|
|response to hypoxia|
|response to acid chemical|
|response to decreased oxygen levels|
|regulation of binding|
|response to oxygen levels|
|developmental growth|
|response to peptide hormone|
|growth|
|external side of plasma membrane|
|blood vessel morphogenesis|
|gland development|
|response to peptide|
|muscle structure development|
|blood vessel development|
|cellular response to growth factor stimulus|
|vasculature development|
|cardiovascular system development|
|heart development|
|response to growth factor|
|cell population proliferation|
|hemopoiesis|
|tissue morphogenesis|
|hematopoietic or lymphoid organ development|
|cell surface|
|immune system development|
|tube morphogenesis|
|regulation of growth|
|negative regulation of cell population proliferation|
|enzyme linked receptor protein signaling pathway|
|regulation of cellular response to stress|
|regulation of MAPK cascade|
|cellular protein-containing complex assembly|
|tube development|
|response to lipid|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|response to hormone|
|positive regulation of cell population proliferation|
|animal organ morphogenesis|
|cell migration|
|protein phosphorylation|
|regulation of cellular component movement|
|response to organonitrogen compound|
|cell motility|
|localization of cell|
|response to nitrogen compound|
|response to abiotic stimulus|
|cellular response to endogenous stimulus|
|negative regulation of signal transduction|
|phosphorylation|
|locomotion|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|integral component of plasma membrane|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of response to stress|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|regulation of phosphorylation|
|extracellular space|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|homeostatic process|
|cell development|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp360|Genistein 15μM R07 exp360]]|-1.7|
|[[:results:exp262|Alda-1 10μM R06 exp262]]|1.71|
|[[:results:exp131|L-74142 5μM R03 exp131]]|1.71|
|[[:results:exp132|Metformin 40μM R03 exp132]]|1.72|
|[[:results:exp477|DKK1 89ng/ml R08 exp477]]|1.75|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|1.79|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|1.81|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|1.88|
|[[:results:exp372|Ibrutinib 1μM R07 exp372]]|1.98|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|2.12|
|[[:results:exp141|Nifurtimox 1μM R03 exp141]]|2.34|
|[[:results:exp363|GSK-J4 1-1.25μM to day4 R07 exp363]]|2.49|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15133
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.24 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TGFBR3 Expression in NALM6 Cells: 4.24'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>