TGS1 [The Human Chemical-Genetic Interaction Map Project]

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======= TGS1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TGS1
  * **<color #00a2e8>Official Name</color>**: trimethylguanosine synthase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=96764|96764]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96RS0|Q96RS0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TGS1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TGS1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606461|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation. {ECO:0000269|PubMed:11517327, ECO:0000269|PubMed:11912212, ECO:0000269|PubMed:16687569, ECO:0000269|PubMed:18775984}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Methyltransf 15|
|Methyltransf 18|
|Met 10|
|UPF0020|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|RNA trimethylguanosine synthase activity|
|7-methylguanosine cap hypermethylation|
|RNA methyltransferase activity|
|small nuclear ribonucleoprotein complex|
|7-methylguanosine RNA capping|
|RNA capping|
|spliceosomal snRNP assembly|
|Cajal body|
|RNA methylation|
|RNA modification|
|ribonucleoprotein complex assembly|
|ribonucleoprotein complex subunit organization|
|macromolecule methylation|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions|
|methylation|
|regulation of lipid metabolic process|
|RNA splicing|
|ribonucleoprotein complex biogenesis|
|mRNA processing|
|mRNA metabolic process|
|cellular protein-containing complex assembly|
|nucleolus|
|RNA processing|
|protein-containing complex assembly|
|extracellular space|
|RNA metabolic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|-2.23|
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|-2.08|
|[[:results:exp423|Zebularine 20μM R07 exp423]]|-1.97|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|-1.93|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|-1.92|
|[[:results:exp300|VE-822 0.04μM R06 exp300]]|-1.83|
|[[:results:exp495|IWR1 50μM R08 exp495]]|-1.76|
|[[:results:exp287|HMS-I2 5μM R06 exp287]]|-1.72|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-1.72|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|1.74|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|1.83|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|2.31|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.674|
|[[:human genes:r:rnmt|RNMT]]|0.569|
|[[:human genes:o:oraov1|ORAOV1]]|0.529|
|[[:human genes:r:rtcb|RTCB]]|0.518|
|[[:human genes:g:gmppb|GMPPB]]|0.507|
|[[:human genes:p:pelo|PELO]]|0.504|
|[[:human genes:t:thg1l|THG1L]]|0.501|
|[[:human genes:y:yars|YARS]]|0.49|
|[[:human genes:a:adsl|ADSL]]|0.487|
|[[:human genes:p:pmm2|PMM2]]|0.487|
|[[:human genes:a:atxn10|ATXN10]]|0.486|
|[[:human genes:e:eny2|ENY2]]|0.485|
|[[:human genes:d:dpagt1|DPAGT1]]|0.482|
|[[:human genes:e:eif4e|EIF4E]]|0.478|
|[[:human genes:u:uhrf1|UHRF1]]|0.473|
|[[:human genes:a:alg2|ALG2]]|0.466|
|[[:human genes:a:alg1|ALG1]]|0.465|
|[[:human genes:m:mars|MARS]]|0.465|
|[[:human genes:g:gemin5|GEMIN5]]|0.464|
|[[:human genes:r:rptor|RPTOR]]|0.463|
|[[:human genes:t:triap1|TRIAP1]]|0.462|
|[[:human genes:g:gfpt1|GFPT1]]|0.46|
|[[:human genes:r:rpe|RPE]]|0.459|
|[[:human genes:a:alg13|ALG13]]|0.455|
|[[:human genes:h:haus8|HAUS8]]|0.451|
|[[:human genes:g:gemin6|GEMIN6]]|0.449|
|[[:human genes:u:uap1|UAP1]]|0.447|
|[[:human genes:h:hspd1|HSPD1]]|0.447|
|[[:human genes:m:med16|MED16]]|0.442|
|[[:human genes:e:eno1|ENO1]]|0.441|
|[[:human genes:m:meaf6|MEAF6]]|0.438|
|[[:human genes:t:tbca|TBCA]]|0.438|
|[[:human genes:c:crcp|CRCP]]|0.437|
|[[:human genes:t:ten1|TEN1]]|0.436|
|[[:human genes:p:pam16|PAM16]]|0.432|
|[[:human genes:n:nae1|NAE1]]|0.43|
|[[:human genes:d:ddx55|DDX55]]|0.428|
|[[:human genes:o:oip5|OIP5]]|0.427|
|[[:human genes:b:bub3|BUB3]]|0.427|
|[[:human genes:t:tti2|TTI2]]|0.425|
|[[:human genes:d:dhps|DHPS]]|0.424|
|[[:human genes:r:rpp21|RPP21]]|0.423|
|[[:human genes:v:vezt|VEZT]]|0.422|
|[[:human genes:c:cct7|CCT7]]|0.422|
|[[:human genes:o:osgep|OSGEP]]|0.421|
|[[:human genes:a:abcf1|ABCF1]]|0.42|
|[[:human genes:u:uxt|UXT]]|0.419|
|[[:human genes:e:eif3f|EIF3F]]|0.417|
|[[:human genes:p:pcbp2|PCBP2]]|0.415|
|[[:human genes:c:csnk2b|CSNK2B]]|0.415|
|[[:human genes:k:kntc1|KNTC1]]|0.414|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.414|
|[[:human genes:d:ddx20|DDX20]]|0.414|
|[[:human genes:n:nars|NARS]]|0.41|
|[[:human genes:w:wdr59|WDR59]]|0.41|
|[[:human genes:s:srp14|SRP14]]|0.409|
|[[:human genes:t:timm13|TIMM13]]|0.409|
|[[:human genes:t:taz|TAZ]]|0.408|
|[[:human genes:c:cops8|COPS8]]|0.408|
|[[:human genes:c:chordc1|CHORDC1]]|0.407|
|[[:human genes:t:tprkb|TPRKB]]|0.404|
|[[:human genes:p:pgk1|PGK1]]|0.402|
|[[:human genes:d:dad1|DAD1]]|0.401|
|[[:human genes:a:alg14|ALG14]]|0.4|
|[[:human genes:t:tamm41|TAMM41]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 128/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|4/28|
|blood|1/28|
|bone|4/26|
|breast|7/33|
|central nervous system|5/56|
|cervix|0/4|
|colorectal|6/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|3/16|
|kidney|4/21|
|liver|3/20|
|lung|15/75|
|lymphocyte|6/16|
|ovary|2/26|
|pancreas|2/24|
|peripheral nervous system|4/16|
|plasma cell|5/15|
|prostate|1/1|
|skin|1/24|
|soft tissue|2/9|
|thyroid|0/2|
|upper aerodigestive|5/22|
|urinary tract|7/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4119
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.57 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TGS1 Expression in NALM6 Cells: 6.57'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>