THBS2 [The Human Chemical-Genetic Interaction Map Project]

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======= THBS2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: THBS2
  * **<color #00a2e8>Official Name</color>**: thrombospondin 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7058|7058]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P35442|P35442]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=THBS2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20THBS2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/188061|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to the thrombospondin family. It is a disulfide-linked homotrimeric glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein has been shown to function as a potent inhibitor of tumor growth and angiogenesis. Studies of the mouse counterpart suggest that this protein may modulate the cell surface properties of mesenchymal cells and be involved in cell adhesion and migration. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Ligand for CD36 mediating antiangiogenic properties. {ECO:0000269|PubMed:20714802}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TSP 1|
|EGF 3|
|VWC|
|EGF CA|
|TSP C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|platelet alpha granule|
|positive regulation of synapse assembly|
|basement membrane|
|negative regulation of angiogenesis|
|regulation of synapse assembly|
|negative regulation of blood vessel morphogenesis|
|negative regulation of vasculature development|
|extracellular matrix structural constituent|
|heparin binding|
|regulation of synapse organization|
|regulation of synapse structure or activity|
|regulation of angiogenesis|
|regulation of vasculature development|
|collagen-containing extracellular matrix|
|positive regulation of cellular component biogenesis|
|positive regulation of nervous system development|
|calcium ion binding|
|regulation of nervous system development|
|cell adhesion|
|biological adhesion|
|negative regulation of developmental process|
|regulation of cellular component biogenesis|
|regulation of anatomical structure morphogenesis|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|positive regulation of developmental process|
|positive regulation of multicellular organismal process|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp480|ETC-159 50μM R08 exp480]]|-1.94|
|[[:results:exp145|PNU96415E 10μM R03 exp145]]|-1.9|
|[[:results:exp140|Nicotinate 1000μM R03 exp140]]|-1.81|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|-1.77|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15741
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.53 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='THBS2 Expression in NALM6 Cells: 0.53'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>