THBS3 [The Human Chemical-Genetic Interaction Map Project]

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======= THBS3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: THBS3
  * **<color #00a2e8>Official Name</color>**: thrombospondin 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7059|7059]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P49746|P49746]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=THBS3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20THBS3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/188062|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to the thrombospondin family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. This protein forms a pentameric molecule linked by a single disulfide bond. This gene shares a common promoter with metaxin 1. Alternate splicing results in coding and non-coding transcript variants. [provided by RefSeq, Nov 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Can bind to fibrinogen, fibronectin, laminin and type V collagen.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|EGF CA|
|TSP C|
|COMP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|bone trabecula formation|
|bone trabecula morphogenesis|
|ossification involved in bone maturation|
|bone maturation|
|animal organ maturation|
|trabecula formation|
|growth plate cartilage development|
|endochondral bone growth|
|trabecula morphogenesis|
|cartilage development involved in endochondral bone morphogenesis|
|bone growth|
|endochondral bone morphogenesis|
|organ growth|
|bone morphogenesis|
|cell-matrix adhesion|
|extracellular matrix structural constituent|
|anatomical structure maturation|
|heparin binding|
|cartilage development|
|cell-substrate adhesion|
|bone development|
|connective tissue development|
|skeletal system morphogenesis|
|developmental maturation|
|ossification|
|collagen-containing extracellular matrix|
|developmental growth|
|growth|
|skeletal system development|
|perinuclear region of cytoplasm|
|calcium ion binding|
|anatomical structure formation involved in morphogenesis|
|cell adhesion|
|biological adhesion|
|animal organ morphogenesis|
|tissue development|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp260|ABT-702 0.1μM R06 exp260]]|-1.78|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|-1.74|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|1.76|
|[[:results:exp113|1-Methyl-nicotinamide-chloride 1000μM R03 exp113]]|1.77|
|[[:results:exp124|GSK343 3μM R03 exp124]]|1.84|
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|1.84|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3291
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='THBS3 Expression in NALM6 Cells: 2.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>