THOC2 [The Human Chemical-Genetic Interaction Map Project]

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======= THOC2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: THOC2
  * **<color #00a2e8>Official Name</color>**: THO complex 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57187|57187]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8NI27|Q8NI27]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=THOC2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20THOC2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300395|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The TREX multiprotein complex binds specifically to spliced mRNAs to facilitate mRNA export. The protein encoded by this gene is a member of the THO complex, a subset of the TREX complex. The encoded protein interacts with the THOC1 protein.[provided by RefSeq, Jun 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. THOC2 (and probably the THO complex) is involved in releasing mRNA from nuclear speckle domains. Required for NXF1 localization to the nuclear rim. Plays a role for proper neuronal development. {ECO:0000269|PubMed:11979277, ECO:0000269|PubMed:15833825, ECO:0000269|PubMed:15998806, ECO:0000269|PubMed:17190602, ECO:0000269|PubMed:18974867, ECO:0000269|PubMed:22893130, ECO:0000269|PubMed:23222130, ECO:0000269|PubMed:26166480}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Thoc2|
|Tho2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|THO complex|
|THO complex part of transcription export complex|
|viral mRNA export from host cell nucleus|
|translocation of molecules into other organism involved in symbiotic interaction|
|translocation of molecules into host|
|transcription export complex|
|poly(A)+ mRNA export from nucleus|
|multi-organism transport|
|multi-organism localization|
|mRNA 3-end processing|
|mRNA-containing ribonucleoprotein complex export from nucleus|
|mRNA export from nucleus|
|nuclear chromosome, telomeric region|
|ribonucleoprotein complex export from nucleus|
|ribonucleoprotein complex localization|
|RNA export from nucleus|
|RNA 3-end processing|
|protein export from nucleus|
|mRNA transport|
|interaction with host|
|nuclear export|
|mRNA binding|
|RNA transport|
|nucleic acid transport|
|establishment of RNA localization|
|RNA localization|
|nucleobase-containing compound transport|
|protein-containing complex localization|
|nucleocytoplasmic transport|
|nuclear transport|
|RNA splicing|
|nuclear speck|
|mRNA processing|
|mRNA metabolic process|
|symbiotic process|
|neuron development|
|interspecies interaction between organisms|
|RNA processing|
|intracellular protein transport|
|neuron differentiation|
|protein transport|
|intracellular transport|
|generation of neurons|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|neurogenesis|
|cell development|
|RNA metabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp492|iCRT14 30μM R08 exp492]]|-2.32|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|-1.77|
|[[:results:exp16|DABN 2μM R00 exp16]]|1.73|
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|1.79|
|[[:results:exp292|Menadione 5μM R06 exp292]]|1.8|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|1.81|
|[[:results:exp341|BRD2 inhibitor II 20μM R07 exp341]]|1.88|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|1.9|
|[[:results:exp462|Cadmium 60μM R08 exp462]]|1.93|
|[[:results:exp298|Sucrose 20000μM R06 exp298]]|1.99|
|[[:results:exp113|1-Methyl-nicotinamide-chloride 1000μM R03 exp113]]|2|
|[[:results:exp272|CHIR-124 0.04μM R06 exp272]]|2.08|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|2.3|
|[[:results:exp271|CCT251545 0.2μM R06 exp271]]|2.41|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 416/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|16/28|
|blood|22/26|
|bone|19/26|
|breast|20/30|
|central nervous system|22/49|
|cervix|1/4|
|colorectal|8/17|
|esophagus|4/11|
|fibroblast|0/1|
|gastric|8/14|
|kidney|7/18|
|liver|11/19|
|lung|36/72|
|lymphocyte|10/16|
|ovary|18/25|
|pancreas|14/22|
|peripheral nervous system|12/15|
|plasma cell|11/12|
|prostate|1/1|
|skin|14/20|
|soft tissue|6/9|
|thyroid|1/2|
|upper aerodigestive|9/22|
|urinary tract|14/28|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 298
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.99 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='THOC2 Expression in NALM6 Cells: 7.99'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>