THSD7A [The Human Chemical-Genetic Interaction Map Project]

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======= THSD7A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: THSD7A
  * **<color #00a2e8>Official Name</color>**: thrombospondin type 1 domain containing 7A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=221981|221981]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UPZ6|Q9UPZ6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=THSD7A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20THSD7A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612249|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is found almost exclusively in endothelial cells from placenta and umbilical cord. The encoded protein appears to interact with alpha(V)beta(3) integrin and paxillin to inhibit endothelial cell migration and tube formation. This protein may be involved in cytoskeletal organization. Variations in this gene may be associated with low bone mineral density in osteoporosis. [provided by RefSeq, Aug 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  The soluble form promotes endothelial cell migration and filopodia formationduring angiogenesis via a FAK-dependent mechanism. {ECO:0000269|PubMed:22194972}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TSP 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|actin cytoskeleton reorganization|
|cell projection|
|angiogenesis|
|blood vessel morphogenesis|
|blood vessel development|
|actin cytoskeleton organization|
|vasculature development|
|cardiovascular system development|
|actin filament-based process|
|tube morphogenesis|
|tube development|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|cytoskeleton organization|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp111|R-DABN 8μM R03 exp111]]|1.75|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|1.79|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|2.17|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|2.43|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|2.51|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|2.52|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|2.74|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|3.07|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|3.51|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4858
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.75 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='THSD7A Expression in NALM6 Cells: -0.75'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>