THY1 [The Human Chemical-Genetic Interaction Map Project]

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======= THY1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: THY1
  * **<color #00a2e8>Official Name</color>**: Thy-1 cell surface antigen
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7070|7070]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P04216|P04216]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=THY1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20THY1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/188230|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ig|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of Rho-dependent protein serine/threonine kinase activity|
|GPI anchor binding|
|retinal cone cell differentiation|
|retinal cone cell development|
|axolemma|
|negative regulation of neuron projection regeneration|
|positive regulation of heterotypic cell-cell adhesion|
|positive regulation of cellular extravasation|
|camera-type eye photoreceptor cell differentiation|
|anchored component of external side of plasma membrane|
|negative regulation of T cell receptor signaling pathway|
|positive regulation of focal adhesion assembly|
|regulation of heterotypic cell-cell adhesion|
|cell-substrate adherens junction assembly|
|negative regulation of antigen receptor-mediated signaling pathway|
|focal adhesion assembly|
|neuronal cell body membrane|
|dendrite membrane|
|regulation of neuron projection regeneration|
|regulation of cellular extravasation|
|negative regulation of protein tyrosine kinase activity|
|positive regulation of adherens junction organization|
|positive regulation of cell junction assembly|
|eye photoreceptor cell development|
|adherens junction assembly|
|regulation of T cell receptor signaling pathway|
|positive regulation of release of sequestered calcium ion into cytosol|
|cell-substrate junction assembly|
|eye photoreceptor cell differentiation|
|photoreceptor cell development|
|receptor clustering|
|retina morphogenesis in camera-type eye|
|positive regulation of cell-matrix adhesion|
|negative regulation of peptidyl-tyrosine phosphorylation|
|positive regulation of calcium ion transport into cytosol|
|photoreceptor cell differentiation|
|neural retina development|
|regulation of focal adhesion assembly|
|regulation of cell-substrate junction assembly|
|regulation of antigen receptor-mediated signaling pathway|
|regulation of adherens junction organization|
|negative regulation of axonogenesis|
|positive regulation of calcium ion transmembrane transport|
|regulation of release of sequestered calcium ion into cytosol|
|adherens junction organization|
|localization within membrane|
|regulation of cell junction assembly|
|regulation of protein tyrosine kinase activity|
|integrin-mediated signaling pathway|
|negative regulation of cell morphogenesis involved in differentiation|
|regulation of calcium ion transport into cytosol|
|camera-type eye morphogenesis|
|regulation of cell-matrix adhesion|
|positive regulation of calcium ion transport|
|positive regulation of cell-substrate adhesion|
|regulation of sequestering of calcium ion|
|cell-matrix adhesion|
|positive regulation of leukocyte migration|
|growth cone|
|integrin binding|
|retina development in camera-type eye|
|positive regulation of cation transmembrane transport|
|regulation of calcium ion transmembrane transport|
|eye morphogenesis|
|negative regulation of neuron projection development|
|positive regulation of ion transmembrane transport|
|cell junction assembly|
|T cell receptor signaling pathway|
|negative regulation of cell projection organization|
|cell-substrate adhesion|
|regulation of axonogenesis|
|protein autophosphorylation|
|regulation of leukocyte migration|
|positive regulation of T cell activation|
|positive regulation of transmembrane transport|
|regulation of cell-substrate adhesion|
|cell junction organization|
|positive regulation of leukocyte cell-cell adhesion|
|negative regulation of neuron differentiation|
|negative regulation of protein kinase activity|
|membrane raft|
|negative regulation of kinase activity|
|regulation of calcium ion transport|
|regulation of peptidyl-tyrosine phosphorylation|
|positive regulation of cell-cell adhesion|
|sensory organ morphogenesis|
|negative regulation of cell migration|
|negative regulation of cell motility|
|positive regulation of ion transport|
|negative regulation of transferase activity|
|GTPase activator activity|
|positive regulation of cytosolic calcium ion concentration|
|negative regulation of neurogenesis|
|antigen receptor-mediated signaling pathway|
|regulation of leukocyte cell-cell adhesion|
|regulation of cell morphogenesis involved in differentiation|
|negative regulation of cellular component movement|
|negative regulation of nervous system development|
|camera-type eye development|
|regulation of T cell activation|
|angiogenesis|
|apical plasma membrane|
|negative regulation of locomotion|
|regulation of cytosolic calcium ion concentration|
|negative regulation of cell development|
|regulation of cation transmembrane transport|
|eye development|
|positive regulation of lymphocyte activation|
|visual system development|
|sensory system development|
|regulation of metal ion transport|
|external side of plasma membrane|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|positive regulation of leukocyte activation|
|negative regulation of protein phosphorylation|
|blood vessel morphogenesis|
|positive regulation of GTPase activity|
|focal adhesion|
|positive regulation of cell activation|
|dendrite|
|cellular calcium ion homeostasis|
|negative regulation of immune system process|
|negative regulation of phosphorylation|
|immune response-activating cell surface receptor signaling pathway|
|calcium ion homeostasis|
|protein kinase binding|
|cellular divalent inorganic cation homeostasis|
|regulation of ion transmembrane transport|
|protein localization to membrane|
|immune response-regulating cell surface receptor signaling pathway|
|regulation of GTPase activity|
|blood vessel development|
|regulation of cell morphogenesis|
|divalent inorganic cation homeostasis|
|regulation of neuron projection development|
|positive regulation of cell migration|
|cell-cell adhesion|
|vasculature development|
|regulation of lymphocyte activation|
|regulation of protein serine/threonine kinase activity|
|cardiovascular system development|
|positive regulation of cellular component biogenesis|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|sensory organ development|
|positive regulation of locomotion|
|cellular metal ion homeostasis|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|immune response-activating signal transduction|
|regulation of transmembrane transport|
|negative regulation of protein modification process|
|immune response-regulating signaling pathway|
|regulation of leukocyte activation|
|cell surface|
|metal ion homeostasis|
|activation of immune response|
|cellular cation homeostasis|
|regulation of cell activation|
|cellular ion homeostasis|
|tube morphogenesis|
|regulation of neuron differentiation|
|regulation of cell adhesion|
|regulation of plasma membrane bounded cell projection organization|
|regulation of ion transport|
|negative regulation of cellular component organization|
|cation homeostasis|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|inorganic ion homeostasis|
|regulation of cellular response to stress|
|cellular chemical homeostasis|
|positive regulation of hydrolase activity|
|ion homeostasis|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|neuron development|
|regulation of neurogenesis|
|tube development|
|regulation of cell migration|
|positive regulation of immune response|
|circulatory system development|
|regulation of kinase activity|
|anatomical structure formation involved in morphogenesis|
|cellular homeostasis|
|regulation of cell motility|
|regulation of cellular localization|
|regulation of nervous system development|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|negative regulation of developmental process|
|animal organ morphogenesis|
|regulation of cellular component biogenesis|
|protein phosphorylation|
|regulation of transferase activity|
|regulation of locomotion|
|positive regulation of transport|
|regulation of cellular component movement|
|endoplasmic reticulum|
|neuron differentiation|
|negative regulation of cellular protein metabolic process|
|regulation of anatomical structure morphogenesis|
|negative regulation of protein metabolic process|
|cytoskeleton organization|
|chemical homeostasis|
|cell-cell signaling|
|negative regulation of molecular function|
|regulation of immune response|
|positive regulation of immune system process|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|phosphorylation|
|negative regulation of cell communication|
|negative regulation of signaling|
|integral component of plasma membrane|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of response to stress|
|generation of neurons|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|negative regulation of response to stimulus|
|neurogenesis|
|homeostatic process|
|cell development|
|regulation of immune system process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|regulation of protein modification process|
|regulation of transport|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-2.22|
|[[:results:exp146|Quinacrine 2.5μM R03 exp146]]|-2.19|
|[[:results:exp72|LB-100 4.1μM R02 exp72]]|-1.95|
|[[:results:exp518|RK-33 8μM R08 exp518]]|-1.95|
|[[:results:exp145|PNU96415E 10μM R03 exp145]]|-1.87|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|-1.84|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|-1.82|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|-1.78|
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|1.76|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|1.87|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15974
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.79 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='THY1 Expression in NALM6 Cells: -2.79'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>