TIFAB [The Human Chemical-Genetic Interaction Map Project]

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======= TIFAB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TIFAB
  * **<color #00a2e8>Official Name</color>**: TIFA inhibitor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=497189|497189]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6ZNK6|Q6ZNK6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TIFAB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TIFAB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612663|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Inhibits TIFA-mediated TRAF6 activation possibly by inducing a conformational change in TIFA. {ECO:0000269|PubMed:15047173}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FHA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|learned vocalization behavior|
|mastication|
|negative regulation of saliva secretion|
|hard palate morphogenesis|
|vestibulocochlear nerve formation|
|negative regulation of relaxation of muscle|
|thorax and anterior abdomen determination|
|zygotic determination of anterior/posterior axis, embryo|
|regulation of saliva secretion|
|vestibulocochlear nerve morphogenesis|
|cranial nerve formation|
|learned vocalization behavior or vocal learning|
|vestibulocochlear nerve development|
|peristalsis|
|regulation of relaxation of muscle|
|trigeminal nerve development|
|auditory behavior|
|genitalia morphogenesis|
|mechanosensory behavior|
|anterior/posterior axis specification, embryo|
|tripartite regional subdivision|
|craniofacial suture morphogenesis|
|vocalization behavior|
|phasic smooth muscle contraction|
|blastoderm segmentation|
|negative regulation of digestive system process|
|cochlea morphogenesis|
|response to auditory stimulus|
|cranial nerve morphogenesis|
|embryonic axis specification|
|regulation of digestive system process|
|genitalia development|
|anterior/posterior axis specification|
|cochlea development|
|cranial nerve development|
|smooth muscle contraction|
|neuromuscular process controlling balance|
|embryonic pattern specification|
|cranial skeletal system development|
|I-kappaB kinase/NF-kappaB signaling|
|digestive system process|
|nerve development|
|axis specification|
|segmentation|
|inner ear morphogenesis|
|neuromuscular process|
|digestion|
|bone morphogenesis|
|ear morphogenesis|
|regulation of muscle organ development|
|inner ear development|
|bone development|
|response to mechanical stimulus|
|anterior/posterior pattern specification|
|ear development|
|negative regulation of secretion|
|regulation of muscle system process|
|skeletal system morphogenesis|
|muscle contraction|
|sensory organ morphogenesis|
|learning or memory|
|sex differentiation|
|embryonic organ morphogenesis|
|cognition|
|muscle system process|
|regionalization|
|reproductive structure development|
|reproductive system development|
|embryonic organ development|
|pattern specification process|
|negative regulation of transport|
|skeletal system development|
|regulation of body fluid levels|
|sensory organ development|
|embryonic morphogenesis|
|behavior|
|regulation of system process|
|developmental process involved in reproduction|
|regulation of secretion|
|anatomical structure formation involved in morphogenesis|
|animal organ morphogenesis|
|embryo development|
|response to abiotic stimulus|
|negative regulation of multicellular organismal process|
|nervous system process|
|reproductive process|
|reproduction|
|intracellular signal transduction|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp480|ETC-159 50μM R08 exp480]]|-1.92|
|[[:results:exp165|RO-3306 3 to 4μM on day4 R04 exp165]]|1.7|
|[[:results:exp482|Fas-L 44ng/ml R08 exp482]]|1.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3440
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -6.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TIFAB Expression in NALM6 Cells: -6.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>