TIMELESS [The Human Chemical-Genetic Interaction Map Project]

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======= TIMELESS =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TIMELESS
  * **<color #00a2e8>Official Name</color>**: timeless circadian regulator
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8914|8914]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UNS1|Q9UNS1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TIMELESS&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TIMELESS|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603887|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays an important role in the control of DNA replication, maintenance of replication fork stability, maintenance of genome stability throughout normal DNA replication and in the regulation of the circadian clock. Involved in the determination of period length and in the DNA damage-dependent phase advancing of the circadian clock. Negatively regulates CLOCK|NPAS2-ARTNL/BMAL1|ARTNL2/BMAL2-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus. Forms a complex with TIPIN and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress. Timeless promotes TIPIN nuclear localization. Involved in cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. May also play an important role in epithelial cell morphogenesis and formation of branching tubules. {ECO:0000269|PubMed:17141802, ECO:0000269|PubMed:17296725, ECO:0000269|PubMed:23418588, ECO:0000269|PubMed:9856465}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TIMELESS C|
|TIMELESS|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cellular response to bleomycin|
|response to bleomycin|
|replication fork arrest|
|cellular response to cisplatin|
|replication fork protection complex|
|response to cisplatin|
|positive regulation of double-strand break repair via homologous recombination|
|replication fork protection|
|cellular response to hydroxyurea|
|response to hydroxyurea|
|DNA replication checkpoint|
|response to antimetabolite|
|negative regulation of DNA-dependent DNA replication|
|positive regulation of double-strand break repair|
|positive regulation of DNA recombination|
|negative regulation of DNA replication|
|DNA-dependent DNA replication maintenance of fidelity|
|regulation of double-strand break repair via homologous recombination|
|regulation of DNA-dependent DNA replication|
|site of double-strand break|
|positive regulation of DNA repair|
|regulation of double-strand break repair|
|response to antineoplastic agent|
|positive regulation of response to DNA damage stimulus|
|regulation of DNA recombination|
|regulation of DNA replication|
|regulation of circadian rhythm|
|cellular response to antibiotic|
|DNA-dependent DNA replication|
|detection of abiotic stimulus|
|regulation of DNA repair|
|branching morphogenesis of an epithelial tube|
|circadian rhythm|
|DNA integrity checkpoint|
|morphogenesis of a branching epithelium|
|morphogenesis of a branching structure|
|lung development|
|respiratory tube development|
|positive regulation of DNA metabolic process|
|cell cycle checkpoint|
|respiratory system development|
|cellular response to toxic substance|
|DNA replication|
|regulation of response to DNA damage stimulus|
|cellular response to inorganic substance|
|nuclear chromatin|
|rhythmic process|
|cell cycle phase transition|
|response to antibiotic|
|epithelial tube morphogenesis|
|cellular response to peptide|
|regulation of DNA metabolic process|
|cellular response to drug|
|morphogenesis of an epithelium|
|response to peptide|
|protein heterodimerization activity|
|cell division|
|response to toxic substance|
|DNA repair|
|response to inorganic substance|
|tissue morphogenesis|
|negative regulation of cell cycle|
|cellular response to organonitrogen compound|
|tube morphogenesis|
|cellular response to nitrogen compound|
|detection of stimulus|
|regulation of cellular response to stress|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|tube development|
|negative regulation of transcription by RNA polymerase II|
|protein homodimerization activity|
|cell cycle process|
|response to organonitrogen compound|
|response to drug|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|epithelium development|
|response to abiotic stimulus|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|cell cycle|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|regulation of cell population proliferation|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|tissue development|
|macromolecule biosynthetic process|
|positive regulation of nucleobase-containing compound metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|-2.22|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|-2.18|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|-1.97|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|-1.96|
|[[:results:exp17|DABN 20μM R00 exp17]]|-1.91|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|-1.83|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|1.71|
|[[:results:exp247|UM0130462 0.025 to 0.035μM day4 R05 exp247]]|1.72|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|1.77|
|[[:results:exp362|GSK-J4 1μM R07 exp362]]|1.78|
|[[:results:exp348|Cyclosporin-A 3μM R07 exp348]]|1.81|
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|1.89|
|[[:results:exp331|A-769662 20μM R07 exp331]]|1.92|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr2j3|POLR2J3]]|0.579|
|[[:human genes:t:tceb3c|TCEB3C]]|0.547|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.543|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.539|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.538|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.528|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.525|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.525|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.525|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.525|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.525|
|[[:human genes:n:nol10|NOL10]]|0.523|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.52|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.517|
|[[:human genes:t:ticrr|TICRR]]|0.514|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.509|
|[[:human genes:r:rpl6|RPL6]]|0.497|
|[[:human genes:c:chd4|CHD4]]|0.492|
|[[:human genes:r:rps2|RPS2]]|0.49|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.489|
|[[:human genes:t:twistnb|TWISTNB]]|0.482|
|[[:human genes:p:polr2d|POLR2D]]|0.48|
|[[:human genes:a:atp6v1b2|ATP6V1B2]]|0.476|
|[[:human genes:e:exosc8|EXOSC8]]|0.474|
|[[:human genes:c:cbwd3|CBWD3]]|0.473|
|[[:human genes:r:rad51|RAD51]]|0.472|
|[[:human genes:n:nup153|NUP153]]|0.472|
|[[:human genes:n:npipb5|NPIPB5]]|0.468|
|[[:human genes:o:orc1|ORC1]]|0.467|
|[[:human genes:s:supt5h|SUPT5H]]|0.467|
|[[:human genes:n:nsf|NSF]]|0.466|
|[[:human genes:s:slc6a17|SLC6A17]]|0.466|
|[[:human genes:c:copb1|COPB1]]|0.465|
|[[:human genes:n:nupl1|NUPL1]]|0.463|
|[[:human genes:r:rrp7a|RRP7A]]|0.461|
|[[:human genes:c:cdca3|CDCA3]]|0.46|
|[[:human genes:c:cbwd6|CBWD6]]|0.459|
|[[:human genes:n:narfl|NARFL]]|0.458|
|[[:human genes:a:atp6v1a|ATP6V1A]]|0.456|
|[[:human genes:p:psma6|PSMA6]]|0.456|
|[[:human genes:p:psmb4|PSMB4]]|0.456|
|[[:human genes:a:aamp|AAMP]]|0.455|
|[[:human genes:p:psmd7|PSMD7]]|0.455|
|[[:human genes:t:tsg101|TSG101]]|0.454|
|[[:human genes:d:dtl|DTL]]|0.453|
|[[:human genes:c:cbwd5|CBWD5]]|0.452|
|[[:human genes:r:rps12|RPS12]]|0.45|
|[[:human genes:n:nfatc4|NFATC4]]|0.45|
|[[:human genes:i:ik|IK]]|0.45|
|[[:human genes:s:sart1|SART1]]|0.45|
|[[:human genes:t:tyms|TYMS]]|0.449|
|[[:human genes:p:pole|POLE]]|0.445|
|[[:human genes:k:kctd17|KCTD17]]|0.444|
|[[:human genes:c:cdc6|CDC6]]|0.444|
|[[:human genes:k:krt78|KRT78]]|0.444|
|[[:human genes:c:c14orf93|C14orf93]]|0.443|
|[[:human genes:c:cln6|CLN6]]|0.443|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.442|
|[[:human genes:r:rpl35|RPL35]]|0.44|
|[[:human genes:r:rps7|RPS7]]|0.439|
|[[:human genes:c:copa|COPA]]|0.438|
|[[:human genes:c:col2a1|COL2A1]]|0.438|
|[[:human genes:f:fam25b|FAM25B]]|0.435|
|[[:human genes:t:traip|TRAIP]]|0.435|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.434|
|[[:human genes:c:cebpz|CEBPZ]]|0.434|
|[[:human genes:e:exosc5|EXOSC5]]|0.434|
|[[:human genes:s:supt6h|SUPT6H]]|0.433|
|[[:human genes:z:znf830|ZNF830]]|0.432|
|[[:human genes:a:atp6v0c|ATP6V0C]]|0.432|
|[[:human genes:p:prim1|PRIM1]]|0.431|
|[[:human genes:p:pcf11|PCF11]]|0.431|
|[[:human genes:s:scgb1c1|SCGB1C1]]|0.43|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.43|
|[[:human genes:a:akirin2|AKIRIN2]]|0.43|
|[[:human genes:r:riok2|RIOK2]]|0.43|
|[[:human genes:h:hivep3|HIVEP3]]|0.43|
|[[:human genes:t:tspy1|TSPY1]]|0.43|
|[[:human genes:p:pbxip1|PBXIP1]]|0.428|
|[[:human genes:t:tuba8|TUBA8]]|0.427|
|[[:human genes:e:exosc9|EXOSC9]]|0.426|
|[[:human genes:a:art5|ART5]]|0.426|
|[[:human genes:v:vasn|VASN]]|0.425|
|[[:human genes:n:npipb8|NPIPB8]]|0.425|
|[[:human genes:p:pola1|POLA1]]|0.425|
|[[:human genes:c:cactin|CACTIN]]|0.424|
|[[:human genes:p:pan3|PAN3]]|0.423|
|[[:human genes:l:lrrc56|LRRC56]]|0.423|
|[[:human genes:p:psmd3|PSMD3]]|0.422|
|[[:human genes:t:trappc11|TRAPPC11]]|0.422|
|[[:human genes:d:ddx56|DDX56]]|0.421|
|[[:human genes:c:cdc45|CDC45]]|0.421|
|[[:human genes:p:ppm1d|PPM1D]]|0.42|
|[[:human genes:t:tspy2|TSPY2]]|0.42|
|[[:human genes:t:tfip11|TFIP11]]|0.42|
|[[:human genes:o:ogfr|OGFR]]|0.42|
|[[:human genes:u:utp3|UTP3]]|0.419|
|[[:human genes:m:med15|MED15]]|0.419|
|[[:human genes:o:orc6|ORC6]]|0.419|
|[[:human genes:s:slc4a1|SLC4A1]]|0.419|
|[[:human genes:c:copz1|COPZ1]]|0.418|
|[[:human genes:u:upf1|UPF1]]|0.417|
|[[:human genes:g:gosr2|GOSR2]]|0.417|
|[[:human genes:n:nol12|NOL12]]|0.417|
|[[:human genes:p:psmb2|PSMB2]]|0.417|
|[[:human genes:p:pigs|PIGS]]|0.417|
|[[:human genes:c:chmp2a|CHMP2A]]|0.415|
|[[:human genes:n:nop16|NOP16]]|0.415|
|[[:human genes:m:med14|MED14]]|0.413|
|[[:human genes:t:tspy8|TSPY8]]|0.413|
|[[:human genes:n:nup160|NUP160]]|0.413|
|[[:human genes:c:ccna2|CCNA2]]|0.412|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.411|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.411|
|[[:human genes:v:vps28|VPS28]]|0.411|
|[[:human genes:p:psmd14|PSMD14]]|0.411|
|[[:human genes:m:madcam1|MADCAM1]]|0.411|
|[[:human genes:a:aaas|AAAS]]|0.41|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.41|
|[[:human genes:p:pwp2|PWP2]]|0.41|
|[[:human genes:d:diexf|DIEXF]]|0.409|
|[[:human genes:a:atp6ap1|ATP6AP1]]|0.408|
|[[:human genes:n:nup43|NUP43]]|0.408|
|[[:human genes:a:aatf|AATF]]|0.407|
|[[:human genes:p:psmc2|PSMC2]]|0.407|
|[[:human genes:r:ranbp2|RANBP2]]|0.407|
|[[:human genes:s:sf3a1|SF3A1]]|0.406|
|[[:human genes:u:utp20|UTP20]]|0.405|
|[[:human genes:p:polr2f|POLR2F]]|0.405|
|[[:human genes:g:golga6b|GOLGA6B]]|0.405|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.404|
|[[:human genes:c:ccdc116|CCDC116]]|0.403|
|[[:human genes:s:stil|STIL]]|0.402|
|[[:human genes:a:akt1s1|AKT1S1]]|0.402|
|[[:human genes:a:acsf2|ACSF2]]|0.402|
|[[:human genes:s:sec13|SEC13]]|0.401|
|[[:human genes:h:hinfp|HINFP]]|0.401|
|[[:human genes:c:cep192|CEP192]]|0.4|
|[[:human genes:e:exosc6|EXOSC6]]|0.4|
|[[:human genes:a:ahctf1|AHCTF1]]|0.4|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 733/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|27/28|
|blood|28/28|
|bone|26/26|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|23/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|20/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 536
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TIMELESS Expression in NALM6 Cells: 7.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>