TIMM13 [The Human Chemical-Genetic Interaction Map Project]

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======= TIMM13 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TIMM13
  * **<color #00a2e8>Official Name</color>**: translocase of inner mitochondrial membrane 13
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=26517|26517]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y5L4|Q9Y5L4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TIMM13&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TIMM13|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607383|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIMM8-TIMM13 complex mediates the import of proteins such as TIMM23, SLC25A12/ARALAR1 and SLC25A13/ARALAR2, while the predominant TIMM9-TIMM10 70 kDa complex mediates the import of much more proteins. {ECO:0000269|PubMed:11489896, ECO:0000269|PubMed:15254020}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-Tim10 DDP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial intermembrane space protein transporter complex|
|chaperone-mediated protein transport|
|protein insertion into mitochondrial inner membrane|
|establishment of protein localization to mitochondrial membrane|
|protein insertion into mitochondrial membrane|
|protein insertion into membrane|
|inner mitochondrial membrane organization|
|protein targeting to mitochondrion|
|establishment of protein localization to mitochondrion|
|protein localization to mitochondrion|
|mitochondrial membrane organization|
|fibrillar center|
|sensory perception of sound|
|sensory perception of mechanical stimulus|
|mitochondrial transport|
|establishment of protein localization to membrane|
|protein targeting|
|mitochondrial inner membrane|
|establishment of protein localization to organelle|
|mitochondrion organization|
|protein localization to membrane|
|protein localization to organelle|
|zinc ion binding|
|membrane organization|
|sensory perception|
|intracellular protein transport|
|mitochondrion|
|nervous system process|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|1.71|
|[[:results:exp482|Fas-L 44ng/ml R08 exp482]]|1.73|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|1.75|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|1.77|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|1.79|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|1.82|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|1.84|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|1.9|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|2.02|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|2.03|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|2.04|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|2.06|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|2.21|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|2.24|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|2.28|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|2.37|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|2.47|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:crls1|CRLS1]]|0.607|
|[[:human genes:t:triap1|TRIAP1]]|0.599|
|[[:human genes:r:romo1|ROMO1]]|0.566|
|[[:human genes:h:hccs|HCCS]]|0.547|
|[[:human genes:t:tamm41|TAMM41]]|0.534|
|[[:human genes:t:taz|TAZ]]|0.534|
|[[:human genes:t:thg1l|THG1L]]|0.533|
|[[:human genes:d:dohh|DOHH]]|0.522|
|[[:human genes:h:hars|HARS]]|0.517|
|[[:human genes:r:rnmt|RNMT]]|0.517|
|[[:human genes:p:pmm2|PMM2]]|0.515|
|[[:human genes:t:trmt10a|TRMT10A]]|0.514|
|[[:human genes:g:gfpt1|GFPT1]]|0.511|
|[[:human genes:c:cycs|CYCS]]|0.5|
|[[:human genes:a:alg5|ALG5]]|0.5|
|[[:human genes:o:opa1|OPA1]]|0.497|
|[[:human genes:d:dhps|DHPS]]|0.493|
|[[:human genes:r:rptor|RPTOR]]|0.49|
|[[:human genes:a:alg1|ALG1]]|0.485|
|[[:human genes:d:dpagt1|DPAGT1]]|0.48|
|[[:human genes:s:slc25a26|SLC25A26]]|0.479|
|[[:human genes:c:casp9|CASP9]]|0.473|
|[[:human genes:u:uap1|UAP1]]|0.471|
|[[:human genes:r:rpe|RPE]]|0.471|
|[[:human genes:g:gmppb|GMPPB]]|0.463|
|[[:human genes:r:rtcb|RTCB]]|0.463|
|[[:human genes:e:exoc4|EXOC4]]|0.462|
|[[:human genes:u:ube2g2|UBE2G2]]|0.46|
|[[:human genes:p:pisd|PISD]]|0.459|
|[[:human genes:d:dnlz|DNLZ]]|0.459|
|[[:human genes:h:hspd1|HSPD1]]|0.453|
|[[:human genes:p:plaa|PLAA]]|0.452|
|[[:human genes:s:srp14|SRP14]]|0.452|
|[[:human genes:s:sec62|SEC62]]|0.444|
|[[:human genes:d:dpf2|DPF2]]|0.444|
|[[:human genes:t:tbca|TBCA]]|0.442|
|[[:human genes:a:apaf1|APAF1]]|0.441|
|[[:human genes:t:tmem41b|TMEM41B]]|0.44|
|[[:human genes:b:bap1|BAP1]]|0.437|
|[[:human genes:m:mrps14|MRPS14]]|0.434|
|[[:human genes:c:coq5|COQ5]]|0.433|
|[[:human genes:t:tmed10|TMED10]]|0.433|
|[[:human genes:a:atp5j|ATP5J]]|0.433|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.431|
|[[:human genes:a:atp5o|ATP5O]]|0.431|
|[[:human genes:a:alg13|ALG13]]|0.43|
|[[:human genes:e:eif4e|EIF4E]]|0.427|
|[[:human genes:b:bak1|BAK1]]|0.425|
|[[:human genes:n:nsd1|NSD1]]|0.425|
|[[:human genes:e:eprs|EPRS]]|0.424|
|[[:human genes:t:thoc6|THOC6]]|0.424|
|[[:human genes:a:alg6|ALG6]]|0.421|
|[[:human genes:d:dad1|DAD1]]|0.421|
|[[:human genes:a:atp5a1|ATP5A1]]|0.421|
|[[:human genes:a:adsl|ADSL]]|0.42|
|[[:human genes:u:utp23|UTP23]]|0.419|
|[[:human genes:a:alg14|ALG14]]|0.419|
|[[:human genes:c:cbfb|CBFB]]|0.418|
|[[:human genes:p:pam16|PAM16]]|0.418|
|[[:human genes:v:vezt|VEZT]]|0.416|
|[[:human genes:b:brwd1|BRWD1]]|0.416|
|[[:human genes:u:uhrf1|UHRF1]]|0.415|
|[[:human genes:a:atp2a2|ATP2A2]]|0.413|
|[[:human genes:t:tgs1|TGS1]]|0.409|
|[[:human genes:e:eny2|ENY2]]|0.408|
|[[:human genes:a:atp5b|ATP5B]]|0.407|
|[[:human genes:t:trnt1|TRNT1]]|0.405|
|[[:human genes:l:lamtor5|LAMTOR5]]|0.405|
|[[:human genes:m:mtor|MTOR]]|0.405|
|[[:human genes:p:pggt1b|PGGT1B]]|0.405|
|[[:human genes:n:nae1|NAE1]]|0.403|
|[[:human genes:u:uso1|USO1]]|0.403|
|[[:human genes:s:sec63|SEC63]]|0.403|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.403|
|[[:human genes:a:atxn10|ATXN10]]|0.402|
|[[:human genes:n:nxt1|NXT1]]|0.4|
|[[:human genes:w:wdr24|WDR24]]|0.4|
|[[:human genes:f:faf2|FAF2]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 230/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|10/28|
|blood|7/28|
|bone|4/26|
|breast|13/33|
|central nervous system|11/56|
|cervix|2/4|
|colorectal|5/17|
|esophagus|8/13|
|fibroblast|1/1|
|gastric|7/16|
|kidney|6/21|
|liver|6/20|
|lung|29/75|
|lymphocyte|12/16|
|ovary|5/26|
|pancreas|6/24|
|peripheral nervous system|2/16|
|plasma cell|2/15|
|prostate|1/1|
|skin|6/24|
|soft tissue|5/9|
|thyroid|1/2|
|upper aerodigestive|11/22|
|urinary tract|3/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1336
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.7 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TIMM13 Expression in NALM6 Cells: 5.7'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>