TIMP1 [The Human Chemical-Genetic Interaction Map Project]

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======= TIMP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TIMP1
  * **<color #00a2e8>Official Name</color>**: TIMP metallopeptidase inhibitor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7076|7076]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P01033|P01033]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TIMP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TIMP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/305370|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. {ECO:0000269|PubMed:1420137, ECO:0000269|PubMed:16917503, ECO:0000269|PubMed:17050530, ECO:0000269|PubMed:1730286, ECO:0000269|PubMed:20545310, ECO:0000269|PubMed:22427646, ECO:0000269|PubMed:24635319, ECO:0000269|PubMed:3839290, ECO:0000269|PubMed:3903517, ECO:0000269|PubMed:8541540, ECO:0000269|PubMed:8576151, ECO:0000269|PubMed:9065415}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TIMP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|connective tissue replacement involved in inflammatory response wound healing|
|negative regulation of trophoblast cell migration|
|connective tissue replacement|
|negative regulation of metallopeptidase activity|
|wound healing involved in inflammatory response|
|inflammatory response to wounding|
|negative regulation of membrane protein ectodomain proteolysis|
|regulation of trophoblast cell migration|
|regulation of metallopeptidase activity|
|regulation of integrin-mediated signaling pathway|
|peptidase inhibitor activity|
|metalloendopeptidase inhibitor activity|
|regulation of membrane protein ectodomain proteolysis|
|negative regulation of reproductive process|
|extracellular matrix disassembly|
|platelet alpha granule lumen|
|basement membrane|
|tissue remodeling|
|protease binding|
|platelet degranulation|
|negative regulation of protein catabolic process|
|regulation of reproductive process|
|growth factor activity|
|cartilage development|
|cytokine activity|
|negative regulation of multi-organism process|
|connective tissue development|
|extracellular matrix|
|negative regulation of endopeptidase activity|
|negative regulation of cellular catabolic process|
|negative regulation of peptidase activity|
|negative regulation of cell migration|
|negative regulation of cell motility|
|aging|
|endoplasmic reticulum lumen|
|negative regulation of cellular component movement|
|negative regulation of catabolic process|
|negative regulation of locomotion|
|extracellular matrix organization|
|negative regulation of proteolysis|
|post-translational protein modification|
|regulation of protein catabolic process|
|extracellular structure organization|
|response to peptide hormone|
|cellular component disassembly|
|regulation of endopeptidase activity|
|regulation of peptidase activity|
|negative regulation of hydrolase activity|
|response to peptide|
|wound healing|
|skeletal system development|
|inflammatory response|
|response to wounding|
|cytokine-mediated signaling pathway|
|regulated exocytosis|
|regulation of proteolysis|
|regulation of multi-organism process|
|negative regulation of catalytic activity|
|exocytosis|
|regulation of cellular catabolic process|
|zinc ion binding|
|regulation of cell migration|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|response to hormone|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|negative regulation of developmental process|
|regulation of locomotion|
|regulation of cellular component movement|
|regulation of catabolic process|
|negative regulation of cell death|
|response to organonitrogen compound|
|secretion by cell|
|cellular response to cytokine stimulus|
|negative regulation of cellular protein metabolic process|
|export from cell|
|cell activation|
|response to nitrogen compound|
|response to cytokine|
|negative regulation of protein metabolic process|
|secretion|
|negative regulation of molecular function|
|negative regulation of multicellular organismal process|
|regulation of hydrolase activity|
|defense response|
|response to endogenous stimulus|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|extracellular space|
|regulation of cell population proliferation|
|regulation of cell death|
|tissue development|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|-1.95|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|1.73|
|[[:results:exp319|ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319]]|2.23|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14857
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.06 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TIMP1 Expression in NALM6 Cells: -0.06'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>