TIPARP [The Human Chemical-Genetic Interaction Map Project]

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======= TIPARP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TIPARP
  * **<color #00a2e8>Official Name</color>**: TCDD inducible poly(ADP-ribose) polymerase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=25976|25976]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q7Z3E1|Q7Z3E1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TIPARP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TIPARP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612480|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Poly [ADP-ribose] polymerase using NAD(+) as a substrate to transfer ADP-ribose onto glutamic acid residues of a protein acceptor; repeated rounds of ADP-ribosylation leads to the formation of poly(ADPribose) chains on the protein, thereby altering the function of the target protein. May play a role in the adaptive response to chemical exposure (TCDD) and thereby mediates certain effects of the chemicals (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PARP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|response to 2,3,7,8-tetrachlorodibenzodioxine|
|protein auto-ADP-ribosylation|
|protein mono-ADP-ribosylation|
|enhancer binding|
|protein ADP-ribosylase activity|
|smooth muscle tissue development|
|androgen metabolic process|
|NAD+ ADP-ribosyltransferase activity|
|protein ADP-ribosylation|
|estrogen metabolic process|
|face morphogenesis|
|platelet-derived growth factor receptor signaling pathway|
|head morphogenesis|
|body morphogenesis|
|face development|
|vasculogenesis|
|female gonad development|
|post-embryonic development|
|roof of mouth development|
|development of primary female sexual characteristics|
|female sex differentiation|
|cellular hormone metabolic process|
|hormone metabolic process|
|gonad development|
|positive regulation of protein catabolic process|
|development of primary sexual characteristics|
|skeletal system morphogenesis|
|steroid metabolic process|
|sex differentiation|
|kidney development|
|renal system development|
|muscle tissue development|
|response to xenobiotic stimulus|
|urogenital system development|
|regulation of protein catabolic process|
|blood vessel morphogenesis|
|reproductive structure development|
|reproductive system development|
|positive regulation of catabolic process|
|blood vessel development|
|skeletal system development|
|vasculature development|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|cardiovascular system development|
|regulation of hormone levels|
|cellular response to organic cyclic compound|
|hemopoiesis|
|hematopoietic or lymphoid organ development|
|immune system development|
|tube morphogenesis|
|developmental process involved in reproduction|
|enzyme linked receptor protein signaling pathway|
|head development|
|tube development|
|circulatory system development|
|response to organic cyclic compound|
|animal organ morphogenesis|
|regulation of catabolic process|
|lipid metabolic process|
|reproductive process|
|reproduction|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|tissue development|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|-2.05|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|-1.88|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|-1.82|
|[[:results:exp235|Geldanamycin 0.01μM R05 exp235]]|1.84|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|2.01|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 11/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|1/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|1/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|2/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17431
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.27 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TIPARP Expression in NALM6 Cells: 4.27'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>